77results about How to "Avoid peaks and valleys in blood concentration" patented technology

The invention relates to the field of Chinese medicine preparation, in particular to a method for preparing tripterine nano structure lipid carrier containing traditional Chinese medicine monomer and application of the tripterine nano structure lipid carrier in preparation of transdermal drugs used for treating psoriasis, rheumatoid arthritis, skin cancer and breast cancer. The tripterine nano structure lipid carrier is characterized by comprising the following components in parts by weight: 1 part of tripterine, 5-100 parts of mixed lipid, 0.5-10 parts of phospholipid, 0.1-15 parts of poloxamer-188 and 0.5-10 parts of vitamin E and tocopherol polyethylene glycol succinate, wherein the mixed lipid is composed of solid lipid monoglycerine and liquid lipid octylic acid/caprin according to the weight ratio of 1: 0.1-10: 1. Tripterine is prepared into the nano structure lipid carrier, the tripterine nano structure lipid carrier in a semi-solid or liquid preparation form is applied in a transdermal way, bioavailability of the tripterine can be improved, toxic response of tripterine can be reduced, and the nano structure lipid carrier provided by the invention has great clinical application value in the improvement of the treatment effect of tripterine.

The invention discloses a thyroid nodule eliminating paste preparation for treating benign non-toxic thyroid nodules. The preparation is composed of the following medicinal raw materials in parts by weight: 6 to 11 parts of radix bupleuri, 10 to 15 parts of curcuma rhizome processed with vinegar, 15 to 20 parts of dioscorea bulbifera, 15 to 20 parts of fried semen brassicae, 6 to 11 parts of processed rhizoma cyperi, 30 to 35 parts of ternate buttercup root, 20 to 25 parts of prunella vulgaris, 10 to 15 parts of salt cake, 10 to 15 parts of rhizoma pinelliae preparata, 15 to 20 parts of laminaria, 15 to 20 parts of alga, and 30 to 35 parts of live oyster.

A Chinese medicine in the form of suppository for treating lumbar vertebra disease, lumbar intervertebral disc protrusion, tonic rachitis and hyperosteogeny is prepared from 10 Chinese-medicinal materials including astragalus root, capejasmine fruit, musk, cinnamon twig, etc through pulverizing, extracting in alcohol, filtering, concentrating by distilling, to obtain concentrated liquid, immersing catgut suture in physiologic saline, baking, shearing short, putting them in bottle, filling said concentrated liquid, sealing and magnetizing.

The invention relates to a cola stable paster which can treat hyperkinetic symptom of children, which comprises back liner, drug layer, release-control layer, paste layer, and anti-paste layer. The invention is characterized in that the back liner is aluminized film; the drug layer is cola stable drug and polyacrylacid ester pressure-sensitive gel; the release-control layer is modified EVA film or nuclear track porous film; the paste layer is cola stable drug and polyacrylacid ester pressure-sensitive gel; the cola stable drug content of drug layer is higher than the cola stable drug content of paste layer. The invention can avoid oral taking, with high biological utilization, stable effect, continuous release, and high safety. The invention also provides relative production.

The invention belongs to the field of pharmaceutic preparations, and particularly relates to a sustained-release suspension composition with lurasidone or salt of the lurasidone and a preparation method of the sustained-release suspension composition. A sustained-release suspension comprises the lurasidone or the salt, capable of being medically accepted, of the lurasidone and a sustained-release micro-capsule coating material medicine composition. According to the preparation, the release time of lurasidone hydrochloride is effectively prolonged, and the blood concentration peak valley phenomenon caused by quick release preparations is avoided. The sustained-release suspension with the lurasidone is low in production cost and has the good taste and medicine release character, the preparation process of the sustained-release suspension with the lurasidone is convenient, and the aim of providing the preparation with the lurasidone or the salt, capable of being medically accepted, of the lurasidone for a patient is achieved, wherein the preparation is convenient to take, high in bioavailability and mild in medicine release.

The invention relates to a compound control-released percutaneous medicine plaster for treating high blood pressure and its preparation method, wherein the paste comprises laminated back lining layer, a pressure-sensitive adhesive framework form medicament-containing layer and a protective film, wherein the compound medicament comprises diuretics, central alpha-acceptor excitant and cirumferential alpha-receptor blocking agent, beta-receptor blocking agent, calcium antagonist and any two of the five categories of medicament for influencing angiotensin II formation and treating high blood pressure. The invention may realize medicine administration once in front of chest or behind the ears, wherein homeostasis blood concentration can be reached.

The invention relates to a medical herbal fiber spongy pad body and a preparation method thereof, the medicinal herbal fiber spongy pad body is shaped by mixing the fibers and medicinal components extracted from such herbal plants as Carex meyeriana, ramuli mori, rhizoma homalonemae, phyllostachys pubescens, cortex eucommiae, radices dipsaci and Gynostemma pentaphylla, and the natural latex. The preparation method comprises the steps of: (1) ingredient cutting; (2) rolling and slicing; (3) digesting and splitting; (4) hydrolyzation; (5) neutralization and degreasing; and (6) processing and molding of the pad body. According to the principles of 'external treatment to internal diseases' and 'lower treatment to upper diseases', the pad body can be made into the shape of mattress, insole, knee pad, belly bank, and shoulder periphery or other needed shapes, which can be conveniently used and replace sponge as pad bodies widely used in sound insulation and heat insulation for health care.

The invention relates to a preparation method for a solid implantation catgut for treating spinal diseases, which is characterized by comprising the following steps of: extracting active ingredients from Chinese medicinal compositions such as musk, rosewood heart wood, frankincense, sappan wood, storax, costustoot, root of red-rooted salvia and the like to obtain concentrated solution of the Chinese medicinal compositions; and adding hyaluronidase into the concentrated solution of the Chinese medicinal compositions to obtain mixed soak solution, and soaking a catgut with the length of between 2.5 and 3.5 centimeters in the mixed soak solution for 10 to 20 days to obtain the solid implantation catgut. The solid implantation catgut for treating spinal diseases can be used for being implanted into an ashi point or acupuncture points to treat spinal diseases. By the solid implantation catgut, medicaments can enter in bodies at constant speed within long time to maintain constant and effective blood concentration, so the phenomenon of the peak valley of the blood concentration due to other administration modes is avoided, adverse reactions can be reduced, and the double effects of the medicaments and the acupuncture points are expressed simultaneously to achieve the optimum pharmacological effect.

The invention relates to a nifedipine controlled-release tablet composition, comprising the following components in percentage by weight: 4.0-35.0% of nifedipine, 5.0-20.0% of polyoxyethylene, 5.0-30.0% of high-viscosity hydrophilic matrix material, 5.0-20.0% of a hydrophobic retarder, 20.0-60.0% of a filling agent, 0-10.0% of an adhesive solution, and 0.5-1.0% of a lubricant. A preparation method of the composition comprises the following steps: micronizing raw materials under a dark condition until the fineness ensures the powder to pass through a 200-mesh sieve, and screening an auxiliary material through a sieve with 80-100 meshes; adding the medicinal raw materials into the adhesive solution, and stirring uniformly for later use; and weighing a formula amount of polyoxyethylene, hydroxypropyl methylcellulose, the retarder namely ethyl cellulose and the filling agent, mixing uniformly, adding the prepared adhesive solution to prepare a soft material, and performing granulation, drying, straightening, addition of the lubricant, total blending, tabletting and package to obtain the composition. The nifedipine controlled-release tablet composition has the advantages that the preparation process is simple and easy, the production cost is low, and the production cycle is short.

The invention provides a trimetazidine hydrochloride bi-layer osmotic pump controlled release tablet and a preparation method thereof. The osmotic pump controlled release tablet is formed by a drug-containing layer, a booster layer and a coating film, wherein the drug-containing layer comprises the following components in percentage by weight: 10-50% of trimetazidine hydrochloride, 30-80% of suspension agent and the balance of other auxiliary materials; the booster layer comprises the following components in percentage by weight: 20-90% of swelling agent, 5-70% of osmotic active substance and 0.5-5% of lubricating agent; the semipermeable coating film comprises 10-20g of semipermeable high polymer material and 1-5g of water-soluble pore-forming agent every 100 tablets. The trimetazidine hydrochloride bi-layer osmotic pump controlled release tablet can realizes constant release of drug in the body of a patient without being affected by pH value of a medium environment, enzyme, gastrointestinal motility and food, and is capable of maintaining the stability of plasma concentration of drug, reducing toxic and side effects of drug, decreasing dosing frequency and improving compliance of the patient.

The invention relates to a tamoxifen citrate emplastrum and a preparation method thereof. A tamoxifen citrate micro emulsion is prepared into a transdermal emplastrum, and the transdermal emplastrum is divided into four layers: an anti-adhesion layer, a viscose layer, a back lining layer and a medicine storage layer. The tamoxifen citrate micro emulsion is used as a drug effect ingredient and comprises tamoxifen citrate used as an active ingredient, polysorbate 80 used as a surfactant, propylene glycol used as a cosurfactant, pure water or distilled water, and the like. Besides the drug effect ingredient, some non-polar polymers, a plasticizer, a tackifier, transdermal enhancer and an antioxidant are also added to the emplastrum. Compared with the traditional dosage forms such as tablets, solutions, oral cavity disintegrants, dispersants and external micro emulsion preparations, the tamoxifen citrate emplastrum has the prominent advantages of safety, low toxicity, convenient and simple use and accurate drug dosage.

The invention relates to an external patch containing anastrozole and a preparation method thereof. The external preparation uses anastrozole as a main drug, and is used for treating breast cancer. The external patch containing anastrozole is absorbed in a percutaneous manner, is uniform in drug release and mild and durable in action. One patch can be continuously used for 7 days. The patch directly acts on skin without passing through gastrointestinal tracts, so that the first pass effect of liver can be avoided, adverse response is reduced, and the occurrence rate of adverse responses is reduced. The external patch has good patient compliance, and is convenient to use and carry.

The invention is concerned with a kind of Chinese traditional medicine for external use and its preparetion method to cure spondylopathy and lumbar illness and pain from rheumatism. It relates to 10 g chinese clematis, 10 g prepared dog button, 10 g long-nosed pitviper, 10 g prepared Sichuan aconite root, 10 g prepared wild aconite root, 10 g prepared common monkshood Daughter root, 10 g cassia, 10 g pubescent angelica root, 20 g common flowering quince fruit, 10 g dried argyi leaf, 6 g white mustard seed, 20 g sevenlobed yam rhizome, 10 g hairy birthwort, 10 gherb a lycopodii, 10 g earth worm, 10 g burreed tuber, 10 g zedoary, 10 g prepared eucommia bark, 10 g cloves, 20 g asarum, 10 g bornel , 10 g anisodus acutangucus, 6 g short-pedicel aconite root and 20 g dried ginger. It has perfect effect for neck and vertebra illness, lumbar intervertebral disc protrusion, spondylitis ankylopoietica, hyperosteogeny, pain from rheumatism, lumbar muscle strain and arthropathy.

The invention relates to a method for preparing the drug material used to treat mammary gland hyperplasia. Wherein, it fixes the drug micro capsule whose corn is the said treatment drug and the drug transparent absorber micro capsule whose corn is the drug transparent absorber, while their weight ratio is 100-10:1-10. The preparation comprises that 1, preparing the drug micro capsule and the drug transparent absorber micro capsule; 2, mixing them at 100-10:1-10 into the micro capsule.

The invention relates to a raloxifene emplastrum and a preparation method thereof. Raloxifene microemulsion is made into a transdermal emplastrum which is divided into an anti-adhesion layer, a viscose layer, a backlining layer and a medicine storage layer. The raloxifene microemulsion taken as a medical ingredient of the raloxifene emplastrum comprises the following ingredients: raloxifene taken as an active ingredient, polysorbate taken as surfactant, propanediol taken as cosurfactant, pure water or distilled water, and the like. Except for the medical ingredient, a plurality of nonpolar polymers, plasticizing agent, caking agent, transdermal enhancing agent and antioxidant are also added in the emplastrum. Compared with the prior dosage forms, such as tablets, the invention has the remarkable advantages of durable medical effect, safety, low toxicity, simple, convenient and sanitary, and accurate medical dosage.

The invention aims to disclose centella total glycoside cataplasm and a preparation method thereof. The centella total glycoside cataplasm comprises the following components in percentage by weight: 5.0%-8.0% of sodium polyacrylate, 0.5%-0.8% of gelatin, 7.0%-10.0% of sorbitol, 1.5%-2.5% of PVP (polyvinylpyrrolidone), 20.0%-40.0% of glycerinum, 0.3%-0.6% of titanium dioxide, 2.0%-4.0% of beta-cyclodextrin, 0.15%-0.4% of tartaric acid, 2.0%-5.0% of centella glycoside powder, 0.05%-0.25% of dihydroxyaluminium aminoacetate and 61.5%-28.45% of purified water. Compared with the prior art, the centella total glycoside cataplasm has the characteristics of being large in drug loading capacity, convenient to use, etc, overcomes the inconvenience caused by pollution to clothes in use, and is suitable for treating trauma, operative wound, burn, keloid and scleroderma, therefore, the aim of the invention is realized.