Doractin dashing agent and method of preparing the same

Abstract

The invention provides a Doramectin dash agent and a preparation method thereof. The Doramectin dash agent consists of propylene glycol, anhydrous ethyl alcohol, azone, Tween-80 and 2, 6-ditertbutyl-p-cresol, wherein the azone is a percutaneous absorption accelerant for accelerating percutaneous absorption of Doramectin; the propylene glycol is a solvent, is used with the azone and has synergism for accelerating the percutaneous absorption of the Doramectin, the Tween-80 is a solubilizing agent for making the Doramectin dissolved easily, the anhydrous ethyl alcohol is an assistant agent for reducing the viscosity of the dash agent and making the dash agent permeate the skin through the clothing hair, and the 2, 6-ditertbutyl-p-cresol is an oxidation inhibitor. The Doramectin dash agent has the advantages that the Doramectin dash agent has little toxicity, lower cost and convenient use, and can be used for killing internal eelworms and external parasites of animals.

Description

(1) Technical field [0001] The invention relates to a medicine for resisting parasitic diseases, in particular to a preparation method of a pouring agent. (2) Background technology [0002] Doramectin is a broad-spectrum, high-efficiency, and non-allergic anthelmintic drug. Compared with Ivermectin, it is absorbed rapidly in animals, has a large volume of distribution in the body, and is eliminated slowly. Effectiveness. At present, most of the doramectin preparations used in veterinary clinics are injections. The drug release of injections is carried out according to the first-order kinetics. It may exceed the minimum toxic concentration, and the effective blood concentration is maintained for a short time, often requiring repeated administration to achieve effective treatment and reduce side effects. Although injection administration improves bioavailability, due to subcutaneous injection to achieve the best effect It requires certain professional skills and is irritatin...

AI Technical Summary

Problems solved by technology

At present, most of the doramectin preparations used in veterinary clinics are injections. The drug release of injections is carried out according to the first-order kinetics. It may exceed the minimum toxic concentration, and the effective blood concentration is maintained for a short time, often requiring repeated administration to achieve effective treatment and reduce side effects. Although injection administration improves bioavailability, due to subcutaneous injection to achieve the best effect It requires certain professional skills and is irritating to the local area, and it is relatively time-consuming and labor-intensive, so its promotion is limited to a certain extent