Clonidine paster for treating children's hyperkinetic symptom, twitch symptom and its preparation method

A technology for children with ADHD and tics, which is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, and sheet delivery, etc., can solve problems such as restricting the treatment of children's diseases, and avoid peaks and valleys of blood drug concentration. phenomenon, improving treatment adherence, reducing impulsivity and hyperactivity

Inactive Publication Date: 2007-08-08
北京克莱斯瑞控释药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Ministry of Health has clearly ordered Ritalin, pemoline, haloperidol, etc. to be included in the scope of anesthesia or psychotropic drug management (doctors’ prescriptions and dosage are strictly limited), which limits the treatment of such children’s diseases

Method used

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  • Clonidine paster for treating children's hyperkinetic symptom, twitch symptom and its preparation method
  • Clonidine paster for treating children's hyperkinetic symptom, twitch symptom and its preparation method
  • Clonidine paster for treating children's hyperkinetic symptom, twitch symptom and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0162] The clonidine patch for treating ADHD and tic disorder in children comprises five layers of a backing layer, a drug storehouse layer, a controlled-release layer, an adhesive layer, and an anti-adhesive layer in sequence, and is characterized in that the backing layer is an aluminized film, and the drug The reservoir layer is clonidine and polyacrylate pressure-sensitive adhesive, the release-controlling layer is modified EVA film, and the adhesive layer is clonidine and polyacrylate pressure-sensitive adhesive. Clonidine microparticles are 2 microns. The content of clonidine in the drug storehouse layer in every 1000 patches is 1.4g, the content of polyacrylate pressure-sensitive adhesive is 15g, and the content of clonidine in the sticking layer is 0.1g, and the content of polyacrylate pressure-sensitive adhesive is 15g .

[0163] The preparation method of the clonidine patch for the treatment of ADHD and tic disorder in children is characterized in that it comprises ...

Embodiment 2

[0170] The clonidine patch for treating ADHD and tic disorder in children comprises five layers of a backing layer, a drug reservoir layer, a controlled release layer, an adhesive layer, and an anti-adhesive layer in turn. The backing layer is an aluminized film, and the drug reservoir layer is Clonidine and polyacrylate pressure-sensitive adhesive, the controlled-release layer is modified EVA film, the adhesive layer is clonidine and polyacrylate pressure-sensitive adhesive, and the clonidine particle size is 30 microns. The content of clonidine in the medicine storehouse layer in every 1000 patches is 3.2g, the content of polyacrylate pressure-sensitive adhesive is 35g, and the content of clonidine in the described pasting layer is 0.3g, and the content of polyacrylate pressure-sensitive adhesive is 35g .

[0171] A preparation method of a clonidine patch for treating ADHD and tic in children.

[0172] Take the amount of preparing 1000 clonidine patches as an example to ill...

Embodiment 3

[0178] The clonidine patch for treating ADHD and tic disorder in children consists of backing layer, drug storage layer, controlled release layer, adhesive layer, and anti-adhesive layer. The backing layer is aluminized film, and the drug storage layer is clonidine and polyacrylate pressure-sensitive adhesive, the controlled-release layer is a nuclear track microporous membrane, the adhesive layer is clonidine and polyacrylate pressure-sensitive adhesive, and the clonidine particle size is 20 microns.

[0179] The content of clonidine in the drug storage layer in every 1000 patches is 2g, the content of polyacrylate pressure-sensitive adhesive is 20g, and there is also 5g of ethyl acetate in the drug storage layer. The content of clonidine in the adhesive layer is 0.2g, the content of polyacrylate pressure-sensitive adhesive is 20g, and the content of ethyl acetate is 10g.

[0180] The preparation method of the clonidine patch for the treatment of ADHD and tic disorder in chil...

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Abstract

The invention relates to a cola stable paster which can treat hyperkinetic symptom of children, which comprises back liner, drug layer, release-control layer, paste layer, and anti-paste layer. The invention is characterized in that the back liner is aluminized film; the drug layer is cola stable drug and polyacrylacid ester pressure-sensitive gel; the release-control layer is modified EVA film or nuclear track porous film; the paste layer is cola stable drug and polyacrylacid ester pressure-sensitive gel; the cola stable drug content of drug layer is higher than the cola stable drug content of paste layer. The invention can avoid oral taking, with high biological utilization, stable effect, continuous release, and high safety. The invention also provides relative production.

Description

technical field [0001] The invention relates to a medicament for treating ADHD and tic in children, more specifically a clonidine patch for treating ADHD and tic in children. The invention also relates to a preparation method of the clonidine patch. Background technique [0002] Hyperactivity in Children (Hyperactivity in Children) is the abbreviation of Hyerkinetic Syndrome of Childhood (Hyerkinetic Syndrome of Childhood), that is, mild brain dysfunction (MBD) syndrome, also known as attention deficit hyperactivity syndrome (ADHD), is a more common Childhood Behavior Disorder Syndrome. The children have normal or near-normal intelligence, hyperactivity, inattention, emotional instability, impulsive willfulness, and learning difficulties in varying degrees. [0003] Tourette syndrome is the abbreviation of Tourette syndrome, also known as multiple tic syndrome, which is the complication of Gilles de laTourette's. It is a syndrome characterized by involuntary muscle twitch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4168A61K9/70A61K47/32A61P25/00A61P43/00
Inventor 夏志慧陈家跃
Owner 北京克莱斯瑞控释药业有限公司
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