10 results about "Tic disorder" patented technology

The invention discloses a child twitch disorder detection and evaluation system based on a task normal form, and belongs to the technical field of medical detection. The system comprises a task stimulation presentation and evaluation device which is used for executing a standardized Go / No-Go cognitive task and synchronously collecting behavior indexes of a subject; the near-infrared brain function imaging device is used for synchronously monitoring the blood oxygen concentration change of the key brain area of the prefrontal lobe of the tested brain during the execution period of the task; the data processing module is used for preprocessing the brain function signals and extracting physiological indexes from the brain function signals; and the result interpretation module is used for performing fusion analysis on the behavior indexes and the physiological indexes based on a quantitative interpretation model pre-established through clustering analysis, and automatically outputting a specific cognitive function subtype interpretation result. According to the method, objective and quantitative evaluation and typing of the core cognitive function defect of the twitch disorder are realized through multi-dimensional information fusion and standardized analysis of behavioral performance and cranial nerve activity.

The invention discloses a rhythmicity resistance feedback training device for children tourette syndrome, comprising a glass tube, the bottom of the glass tube is connected with a flow guide pipeline, one end of the flow guide pipeline away from the glass tube is connected with a piston cylinder, and the center of the top of the piston cylinder is slidably connected with a piston assembly in a penetrating manner; a floating ball assembly is arranged in the top end of the glass tube; a friction assembly is arranged between the piston cylinder and the piston assembly, and pressure adjusting pieces are arranged at the top and the bottom of the friction assembly. When a user lies on the sliding seat, holds the T-shaped rod with two hands and bends knees, the T-shaped rod is pushed downwards, the piston plate presses water in the piston cylinder into the lower half part of the glass tube, the water in the lower half part of the glass tube penetrates through the water spraying pipe to be sprayed to the floating ball body along with the increase of the hydraulic pressure of the lower half part of the glass tube, the floating ball body floats upwards, and the speed of pushing the T-shaped rod downwards is higher. The higher the water flow sprayed by the water spraying pipe is, the higher the floating height of the floating ball body is, and therefore the children can keep the exercise interest.

The invention provides application of whey protein in preparation of a medicine for treating tic disorder, and belongs to the technical field of medicines. The invention provides a therapeutic preparation containing whey protein. The therapeutic preparation can effectively improve exercise symptoms of a patient suffering from tic disorder. The preparation can be independently used, can also be used as an auxiliary treatment means to be combined with a traditional anti-twitch medicine, has multiple effects of regulating neurotransmitter balance, improving intestinal microecology and relieving neuroinflammation, has no adverse reaction of the traditional medicine, and is particularly suitable for long-term use of children patients.

The application discloses a plant lactobacillus and application of the plant lactobacillus in a composition for preventing or treating a tic disorder, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide a plant lactobacillus LP496 isolated from healthy breast milk, wherein the plant lactobacillus LP496 can significantly reduce a tic behavior, improve a stereotypic symptom, improve motor coordination and repair muscle strength damage, realize double neurotransmitter regulation by down-regulating dopamine and up-regulating serotonin, and has a significant protective effect on brain neuron damage. A technical solution point is that the plant lactobacillus LP496 has a preservation number of CGMCC No. 33499. The application further discloses a microbial agent containing the strain or a preparation of the strain, and application of the strain and the microbial agent in preparation of a composition for preventing or treating a tic disorder and related compositions, and provides a safe, effective and mild new microecological intervention scheme for the tic disorder.

The present invention is directed to the treatment of obsessive-compulsive disorder (OCD) and OCD-related disorders (including body dysmorphic disorder, hoarding disorder, trichotillomania (hair pulling disorder), skin picking disorder, substance / medication-induced obsessive-compulsive disorder and related disorders, obsessive-compulsive disorder and related disorders due to another medical condition, and other specified and unspecified obsessive-compulsive disorder and related disorders), tic disorders including Tourette's syndrome, autism spectrum disorder (ASD), and amyotrophic lateral sclerosis (ALS), Parkinson's disease, traumatic brain injury, Provided is a method for treating glutamate excitotoxicity-related disorders, including multiple sclerosis, Huntington's disease, and schizophrenia, comprising administering an effective amount of a histamine type 1 receptor agonist and / or a histamine type 3 receptor antagonist, such as betahistine or a pharmaceutically acceptable salt, analog, metabolite, prodrug, derivative, metabolite, cocrystal, modification, solvate, hydrate, isotope, tautomer, ester, polymorph, or stereoisomer thereof.

The application relates to an infrared image-based intelligent positioning system for acupuncture points of children's tic disorders. The system comprises a calculation module, which calculates a constant temperature coefficient according to the temperature standard deviation and temperature change slope of each grid in a reference frame; a calibration module, which calibrates the temperature of each pixel point according to the average temperature and constant temperature coefficient of multiple constant temperature grids to obtain a target temperature; a determination module, which determines a confidence weight according to the distance between the centroid and multiple candidate acupuncture points of the face; a clustering module, which clusters multiple variable temperature zones according to the centroid distance between the multiple variable temperature zones to obtain multiple clusters, obtains the fluctuation amplitude of the temperature change curve of each central variable temperature zone, the effective duration, the similarity between the temperature change curve and a preset model, and the confidence weight, and determines a high-confidence variable temperature zone; and a positioning module, which determines a target confidence degree according to the confidence weight and fluctuation degree of the variable temperature zone to position the acupuncture points of the face. The application can improve the accuracy of acupuncture point recognition.

Provided are methods of treating neuropsychiatric disorders including obsessive-compulsive related disorders, tic disorders, glutamate excitotoxicity related disorders, autism spectrum disorders, and other medical conditions in patients with a mutation in genes involving function, structure, or plasticity, including but not limited to SHANK3, SAPAP3, NLGN3, NLGN4, NRXN1, CNTNAP2, or MECP2. The methods include administering an effective amount of a histamine type 1 receptor agonist and / or histamine type 3 receptor antagonist or inverse agonist, their pharmaceutically acceptable salts, analogs, metabolites, and prodrugs, including prodrugs of its metabolites, to patients in need of such treatment.

The present invention provides methods for treating obsessive-compulsive disorder (OCD) and OCD-related disorders (somatic deformation disorder, hoarding disorder, depilation disorder), scratch (skin scratching) disorder, substance / drug induced obsessive-compulsive disorder and related disorders, obsessive-compulsive disorder and related disorders caused by another medical condition, and OCD-related disorders. And other specified and unspecified obsessive-compulsive disorders and related disorders); a twitch disorder, including Tourette Syndrome; autism spectrum disorder (ASD); and glutamate excitatory toxicity related disorders, including amyotrophic lateral sclerosis (ALS); parkinson's disease; traumatic brain injury; multiple sclerosis; huntington's disease; and schizophrenia, the method comprising administering an effective amount of a histamine type 1 receptor agonist and / or a histamine type 3 receptor antagonist, the invention also relates to a preparation method of the compound, such as betahistine or pharmaceutically acceptable salts, analogs, metabolites, prodrugs, derivatives, metabolites, co-crystals, modifiers, solvates, hydrates, isotopes, tautomers, esters, polymorphs or stereoisomers thereof.

This invention relates to the field of medical artificial intelligence-assisted diagnostic technology, and in particular to an auxiliary diagnostic system for the prodromal phase of tic disorders in children. Addressing the problem that existing technologies cannot identify the prodromal impulse phase preceding tic movements, this invention, for the first time, extracts facial microtremor features and respiratory stress features from ordinary videos. Using the predicted time of the tic movement as an anchor point, it fuses these two types of features through a gated attention mechanism to generate a prodromal impulse index. The auxiliary diagnostic output module uses this index to determine the prodromal phase, output confidence levels and audiovisual warning signals, and generate a diagnostic report containing the frequency of prodromal events and assessment suggestions. This invention achieves automatic identification of the prodromal impulse phase through cross-modal collaboration of facial microtremors and respiratory patterns, significantly improving the early warning capability of tic disorders and providing an objective time window for clinical behavioral intervention.

The present invention provides for methods of treating obsessive-compulsive disorder (OCD) and OCD-related disorders (body dysmorphic disorder, hoarding disorder, trichotillomania (hair-pulling disorder), excoriation (skin-picking) disorder, substance / medication-induced obsessive-compulsive and related disorder, obsessive- compulsive and related disorder due to another medical condition, and other specified and unspecified obsessive-compulsive and related disorders), Tic disorders including Tourette syndrome, autism spectrum disorder (ASD) and glutamate excitotoxicity related disorders including amyotrophic lateral sclerosis (ALS), Parkinson's disease, traumatic brain injury, multiple sclerosis, Huntington's disease, and schizophrenia, comprising the step of administering an effective amount of a histamine type 1 receptor agonist and / or histamine type 3 receptor antagonist, such as betahistine or its pharmaceutically acceptable salts, analogs, metabolites, prodrugs, derivatives, metabolites, co-crystals, modifications, solvates, hydrates, isotopes, tautomers, esters, polymorphs or stereoisomers.