An implanted flexible biological electrode comprises an electrode simulation contact blade, a metal ring and a metal micro guide wire. The electrode simulation contact blade is communicated with the metal ring through the metal micro guide wire. Insulation layers formed by insulation materials in an injection molding mode are arranged outside the electrode simulation contact blade, the metal ring and the metal micro guide wire, and the surface of the electrode simulation contact blade and the surface of the metal ring are exposed out of the insulation layers. According to a manufacturing method of the implanted flexible biological electrode, the two ends of the helical metal micro guide wire are connected with the electrode simulation contact blade and the metal ring of a connecting end in sequence in a welding mode, the packaging is carried out, finally, finishing is carried out, a packaging sprue gate is removed, and the metal of the electrode simulation contact blade and metal of the metal ring of the connecting end are exposed out. The implanted flexible biological electrode is simple in process and easy to manufacture, the implanted flexible biological electrode is implanted close to the Phil neurons of the human leg, the metal ring is connected with an external circuit, electric signals are provided for the electrode simulation contact blade, and pulse electrical signal simulation is provided for the nerve at the position of the target spot of the leg. The implanted flexible biological electrode is suitable for treating lower limb behavior disorder diseases caused by hemiplegia in clinical medicine.