Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Red peony root injection and its preparation method

A technology for injection and red peony root, which is applied in the field of red peony root injection, can solve the problems of insufficient quality stability, low content of active ingredients, influence on treatment effect and the like, and achieves the effects of rapid onset of action, high bioavailability and good therapeutic effect.

Inactive Publication Date: 2004-03-17
秦吉兴
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chishao injection currently used clinically is a small water needle prepared by the hydroalcoholic method, which has low content of active ingredients and unstable quality, which affects the therapeutic effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 400 g of red peony medicinal materials, cut them into pieces, and use 6 times the amount of 70% ethanol to reflux for extraction twice, the first time is 2 hours, the second time is 1 hour, the extracts are combined, filtered, the filtrate is decompressed to recover ethanol and concentrated to relative The clear paste with a density of 1.18 (50°C) was added with 4 times the amount of water, stirred well, refrigerated for 24 hours, centrifuged at high speed (20000r / min), and the supernatant was concentrated under reduced pressure to a clear paste with a relative density of 1.25 (50°C), Add ethanol to make the alcohol content to 85%, refrigerate for 24 hours, filter the supernatant and add ammonia water to adjust the pH to 8.0, refrigerate for 24 hours, filter, and the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.08 (50 ° C). The concentrated solution was extracted 4 times with an equal volume of water-saturated n-butanol eac...

Embodiment 2

[0016] Take 300 g of red peony medicinal materials, cut them into pieces, and extract 3 times with 8 times the amount of 60% ethanol for 1.5 hours each time. Combine the extracts, filter, and recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.23 (50°C). Add 3 times the amount of water, stir well, refrigerate for 36 hours, centrifuge at high speed (20000r / min), concentrate the supernatant under reduced pressure to a clear paste with a relative density of 1.27 (50°C), add ethanol to make the alcohol content to 80%, refrigerate for 48 hours, filter the supernatant and add ammonia water to adjust pH to 8.0, refrigerate for 28 hours, filter, filtrate under reduced pressure to recover ethanol and concentrate to a concentrated solution with a relative density of 1.14 (50°C), add it to the macropore On the adsorption resin chromatography column, first eluate with water 30 times the weight of the concentrate, discard the eluate, and then ...

Embodiment 3

[0018] Take 1000 g of red peony medicinal materials, cut them into pieces, extract 3 times with 8 times the amount of 70% ethanol, each time for 1 hour, combine the extracts, filter, and recover ethanol from the filtrate under reduced pressure and concentrate to a relative density of 1.16 (50°C) Add 5 times the amount of water, stir evenly, refrigerate for 36 hours, centrifuge at high speed (20000r / min), concentrate the supernatant under reduced pressure to a clear paste with a relative density of 1.26 (50°C), add ethanol to make the alcohol content to 85%, refrigerate for 24 hours, filter the supernatant and add ammonia water to adjust the pH to 8.0, refrigerate for 30 hours, filter, and the filtrate is decompressed to recover ethanol and concentrated to a concentrated solution with a relative density of 1.10 (50 ° C), etc. Extracted with water-saturated n-butanol for 5 times, combined the extracts, recovered n-butanol under reduced pressure and concentrated to a thick paste w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention is one kind of red peony injection prepared with red peony root as material and through alcohol extraction, n-butanol extraction or macroporous resin purification, and adding proper amount of medicinal supplementary material and injection water. It is stable and may be used in intramuscular injection, intravenous injection and intravenous instillation. Pharmacodynamic experiment shows that the medicine of the present invention can improve the behavior disorder of rat with cerebral infarction obviously, reduce the area of cerebral infarction, decrease water content in infracted brain tissue, reduce the peroxidation damage of lipoid in brain tissue and raise the acute oxygen lack tolerance of mouse and thus has excellent treat effect on cerebral infarction.

Description

Technical field [0001] The invention relates to a red peony injection, and also relates to a preparation method of the red peony injection. Background technique [0002] Red peony is a traditional Chinese medicine commonly used, derived from the dried root of Paeonia Lactiflora Pall. or Paeonia veilchii Lyncn, a Ranunculaceae plant. It is included in the 2000 edition of the Pharmacopoeia of the People's Republic of China. It has the effects of clearing heat and cooling blood, dissipating blood stasis and relieving pain. It is clinically used for warm toxin, spotting, vomiting blood and epistaxis, red eyes, swelling and pain, liver depression and hypochondrium pain, and amenorrhea. Menstrual, fall and flutter injury embolism. Pharmacological studies in recent years have shown that red peony has many pharmacological effects such as protecting the heart, increasing coronary blood flow, antithrombotic and atherosclerosis, sedative and analgesic, anti-inflammatory and antibacter...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61P7/02A61P9/10
Inventor 秦吉兴
Owner 秦吉兴
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com