New use of saponins X of dipsacus asperoides
A technology of Dipsacus saponin and medicine, which is applied in the field of new application of Dipsacus saponin X
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preparation example 1
[0016] Preparation Example 1: Preparation of Dipsacus saponin X
[0017] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, filter the extract, and recover the ethanol until it is free. Add water to form a suspension, extract 3 times with n-butanol, combine the lower aqueous layer, apply the sample to the treated D101 macroporous resin (the weight ratio of resin to medicinal material is 1:1), wash 3 column volumes with water, discard Go, then elute 3 column volumes with 30% ethanol, discard, and finally wash 3 column volumes with 50% ethanol, collect the 50% ethanol eluate, concentrate, decolorize with activated carbon, and recrystallize to obtain a content of 98%. Dipsacus saponin X 6g.
[0018] Structure Identification:
[0019] White powder, mp 236-240℃, Liebermann and Molish reaction positive, FAB-MS m / z: 1699 (M + +Na...
preparation example 2
[0020] Preparation Example 2: Preparation of Dipsacus saponin X
[0021] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, and recover the ethanol from the extract until it has no alcohol smell , add ethanol to the concentrated solution until the alcohol concentration is 80%, let it stand overnight; filter it with suction, concentrate the filtrate until it has no alcohol smell, add 5 times the amount of water, let it stand overnight, filter it with suction, and load the filtrate on the treated D101 macroporous resin (The weight ratio of resin to medicinal material is 1:1), washed with 0.5% sodium hydroxide solution for 2 column volumes and then washed with water until neutral, then eluted with 30% ethanol for 3 column volumes, discarded, and finally washed with 50% ethanol 3 column volumes, collect the 50% ethanol eluate, co...
preparation example 3
[0022] Preparation Example 3: Preparation of Dipsacus saponin X
[0023] Take 1 kg of Dipsacus chuanxiong medicinal material, crush it, pass through a 10-mesh sieve, add 10 times the amount (V / W) of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, and recover the ethanol from the extract until it has no alcohol smell , add ethanol to the concentrated solution until the alcohol concentration is 80%, and leave it standing overnight; suction filtration, the filtrate is concentrated to no alcohol smell, add 5 times the amount of water, leave it standing overnight, filter, and the D101 macroporous resin (resin and The weight ratio of medicinal materials is 1:1), wash 2 column volumes with 1.0% sodium hydroxide solution, wash with water until neutral, then elute with 30% ethanol for 3 column volumes, discard, and finally wash 3 columns with 80% ethanol volume, collected 50% ethanol eluate, concentrated and evaporated to dryness to obtain the crude extra...
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