The application discloses a position adjusting mechanism of a safety block on a photographic holder, which comprises a holder main body, a sliding groove arranged on the holder main body, and a safety block arranged in the sliding groove and extending outwards, wherein the position of the safety block is adjusted by an adjusting mechanism arranged on the holder main body. The adjusting mechanism comprises a knob arranged on the back of the holder main body, the knob is rotatably arranged on a positioning column, a second sliding groove is arranged on the knob, and a part of the safety block is slidably arranged in the second sliding groove. When the knob rotates, the safety block moves in the sliding groove and the second sliding groove simultaneously, and the position of the safety block is adjusted. In the position adjusting mechanism of the safety block, the knob can rotate around the positioning column, and during the rotation, the safety block is moved from one side of the sliding groove to the other side of the sliding groove through the limiting action of the sliding groove and the second sliding groove, so that the position of the safety block is adjusted, and the operation is convenient.