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Pharmaceutical composition for treating ischemic cerebral apoplexy and preparation method and application thereof

A technology for ischemic cerebral apoplexy and a composition is applied in the field of medicine to achieve the effects of improving behavioral disorders, improving the ability of long-term survival, and reducing the volume of cerebral infarction

Inactive Publication Date: 2016-10-12
CHONGQING NADPH IND GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the combined application of NADPH and apocynin in the treatment of cerebral ischemic stroke

Method used

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  • Pharmaceutical composition for treating ischemic cerebral apoplexy and preparation method and application thereof
  • Pharmaceutical composition for treating ischemic cerebral apoplexy and preparation method and application thereof
  • Pharmaceutical composition for treating ischemic cerebral apoplexy and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The pharmaceutical composition for the treatment of ischemic stroke in this example, its raw materials are: NADPH 7.5g, apocynin 2.5g;

[0040]The preparation method comprises the following steps: respectively take selected parts by weight of NADPH and apocynin, and mix them uniformly to obtain the product.

Embodiment 2

[0042] The pharmaceutical composition for the treatment of ischemic stroke in this example, its raw materials are composed of: NADPH 6g, apocynin 4g;

[0043] The preparation method comprises the following steps: respectively take selected parts by weight of NADPH and apocynin, and mix them uniformly to obtain the product.

Embodiment 3

[0045] The pharmaceutical composition for the treatment of ischemic stroke in this example, its raw materials are: NADPH 9g, apocynin 1g;

[0046] The preparation method comprises the following steps: respectively take selected parts by weight of NADPH and apocynin, and mix them uniformly to obtain the product.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating ischemic cerebral apoplexy and a preparation method and application thereof. The pharmaceutical composition for treating ischemic cerebral apoplexy is prepared from, by weight, 3-12 parts of NADPH and 0.5-8 parts of apocynin. NADPH and apocynin are applied jointly and act cooperatively in a specific proportion, and the pharmaceutical composition can reduce the cerebral infarction volume, significantly relieve the behavior disorder of cerebral ischemia mice, relieve encephaledema, improve the long-term survival capability of mice and enhance neurological function recovery; besides, the treatment effect of the pharmaceutical composition on ischemic cerebral apoplexy is much better than that of NADPH and apocynin which are applied independently on ischemic cerebral apoplexy, and a synergistic effect is achieved when NADPH and apocynin are applied jointly. Thus, the pharmaceutical composition has the effect of treating ischemic cerebral apoplexy and can serve as a potential drug for treating ischemic cerebral apoplexy.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a pharmaceutical composition for treating ischemic cerebral apoplexy, a preparation method and application thereof. Background technique [0002] Stroke, also known as cerebral apoplexy or cerebrovascular accident, is a sudden-onset cerebral blood circulation disorder and one of the three major diseases that threaten human health. The characteristics of high residual rate and high recurrence rate. Stroke refers to patients with cerebrovascular disease, due to various predisposing factors causing cerebral artery stenosis, occlusion or rupture, resulting in acute cerebral blood circulation disorder, clinically manifested as symptoms of transient or permanent brain dysfunction and signs. Stroke is divided into ischemic stroke and hemorrhagic stroke. In recent years, the number of patients with cerebrovascular diseases in my country has increased year by year, and ischemic cer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7084A61K31/12A61P9/10A61P25/00
CPCA61K31/12A61K31/7084A61K2300/00
Inventor 秦正红李梅
Owner CHONGQING NADPH IND GRP CO LTD
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