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Application of aspirin in treatment of cognitive and behavioral disorders after epilepsy

A technology of aspirin and behavior, applied in the field of medicine, can solve problems such as cognitive impairment of patients

Inactive Publication Date: 2013-09-18
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current measures to reduce cognitive impairment mainly include controlling epileptic seizures and various cognitive therapies, but there are still a considerable number of patients with severe cognitive impairment

Method used

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  • Application of aspirin in treatment of cognitive and behavioral disorders after epilepsy
  • Application of aspirin in treatment of cognitive and behavioral disorders after epilepsy
  • Application of aspirin in treatment of cognitive and behavioral disorders after epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] 1 Materials and methods

[0012] 1.1 Experimental animals and grouping

[0013] Adult healthy clean male SD rats, weighing about 200-250g, were raised in a light and dark environment for 12h-12h (8:00-20:00), free to drink water, and given a standard diet. All animal experiments were handled in strict accordance with the Guidelines for the Care and Use of Laboratory Animals formulated by the National Institutes of Health. Rats were randomly divided into normal control group, model group and aspirin (20 mg / kg, i.p. 1 / d) intervention group. Dosing was started 14 days after the establishment of the model and continued for 28 days.

[0014] 1.2 Experimental materials

[0015] Lithium chloride (Sigma-Aldrich)

[0016] pilocarpine (Sigma-Aldrich)

[0017] aspirin (Sigma-Aldrich)

[0018] Bromomethylscopolamine (Sigma-Aldrich)

[0019] Diazepam injection (Xi'an Lijun Jingjing Pharmaceutical Co., Ltd.)

[0020] 1.3 Establishment of epilepsy model in rats induced by lith...

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Abstract

The invention discloses an application of aspirin in treatment of cognitive and behavioral disorders after epilepsy. The inventor creates a lithium chloride-pilocarpine induced rat model of chronic epilepsy, detects the spatial learning and memory of the rat through a Morris water maze, detects the behavior depression of the rat through a tail suspension test, and finds that the cognitive function and behavior disorder of the epileptic rat are obviously perfected when being dosed with the aspirin at the chronic epilepsy attack stage.

Description

technical field [0001] The invention relates to a new application of aspirin, in particular to the application of aspirin in cognitive and behavioral disorders after epilepsy, and belongs to the technical field of medicine. Background technique [0002] The definition of epilepsy revised by the International League Against Epilepsy (ILAE) in 2001 emphasized that epilepsy is a brain disorder characterized by the persistent presence of incentives to produce recurrent seizures and neurobiological, cognitive, psychological and social consequences. Epilepsy is a complex brain dysfunction disease. Recurrent seizures can lead to abnormal brain functions such as cognition, behavior, and spirit. The principles of antiepileptic therapy should not only focus on reducing and controlling clinical seizures or subclinical discharges, but also focus on cognitive, behavioral, and mental disorders in epileptic patients and their impact on quality of life. [0003] Cognitive function refers ...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61P25/28A61P25/24
Inventor 马磊江文
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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