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Aspirin enteric-coated pellet

A technology of aspirin and enteric-coated pellets, which can be used in medical preparations with non-active ingredients, blood diseases, and extracellular fluid diseases, etc. It can solve the problems that capsules are not easy to pass through the pylorus and the release time is unstable, so as to maintain blood drug concentration , the effect of maintaining balance

Active Publication Date: 2009-12-09
Yung Shin Pharm Ind (Kunshan) Co Ltd
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After taking, because the capsule is completely insoluble in the stomach, the capsule is not easy to pass through the pylorus. Only when the food has been completely digested or almost completely digested can it pass through the pylorus. Under the action of the appropriate pH value of the intestine, the capsule shell dissolves and releases the drug, causing Unstable release time

Method used

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  • Aspirin enteric-coated pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A. Enteric-coated pellet preparation

[0047] Ingredients:

[0048] Aspirin 100g

[0049] Blank ball core 39.36g

[0050] Sodium carboxymethyl starch 3.2g

[0051] Low-substituted hydroxypropyl methylcellulose 4g

[0052] Isopropanol 160mL

[0053] Purified water 20mL

[0054] Eudragit L30D 37.3g

[0055] Glyceryl acetate 2.24g

[0056] Purified water 35mL

[0057] B. The method for preparing enteric-coated pellet preparation:

[0058] Dissolve low-substituted hydroxypropyl cellulose in isopropanol and purified water to form a binding agent; crush aspirin and sodium carboxymethyl starch; put the blank ball core in the coating pan, spray the binding agent, and then add the crushed After aspirin and sodium carboxymethyl starch until the operation is completed. Continue air drying for 3-4 hours to form drug-coated pellets.

[0059] Mix Eudragit L30D with glycerol acetate and purified water evenly to form an enteric coating solution; place the drug-coated pellets i...

Embodiment 2

[0062] A. Enteric-coated pellet preparation

[0063] Ingredients:

[0064] Aspirin 100g

[0065] Blank ball core 21.64g

[0066] Sodium carboxymethyl starch 2.8g

[0067] Low-substituted hydroxypropyl methylcellulose 3.8g

[0068] Ethanol 129mL

[0069] Purified water 18mL

[0070] Eudragit L30D 32.67g

[0071] Glyceryl acetate 1.96g

[0072] Purified water 27mL

[0073] B. Method of preparing the formulation:

[0074] Dissolve low-substituted hydroxypropyl cellulose in ethanol and purified water to form a binding agent; pulverize aspirin and sodium carboxymethyl starch; put the blank ball core in a fluidized bed coating pan, spray the binding agent, and then Add crushed aspirin and sodium starch glycolate until the operation is complete. Continue air drying for 3-4 hours to form drug-coated pellets.

[0075] Mix Eudragit L30D with glycerol acetate and purified water evenly to form an enteric coating solution; place the drug-coated pellets in a fluidized bed coating...

Embodiment 3

[0078] A. Enteric-coated pellet preparation

[0079] Ingredients:

[0080] Aspirin 100g

[0081] Blank ball core 35.08g

[0082] Sodium carboxymethyl starch 2.5g

[0083] Low-substituted hydroxypropyl methylcellulose 3.7g

[0084] Isopropanol 157mL

[0085] Purified water 20mL

[0086] Eudragit L30D 29.17g

[0087] Glyceryl acetate 1.75g

[0088] Purified water 25mL

[0089] B. Method of preparing the formulation:

[0090] Dissolve low-substituted hydroxypropyl cellulose in isopropanol and purified water to form a binding agent; crush aspirin and sodium carboxymethyl starch; put the blank ball core in the coating pan, spray the binding agent, and then add the crushed After aspirin and sodium carboxymethyl starch until the operation is completed. Continue air drying for 3-4 hours to form drug-coated pellets.

[0091] Mix Eudragit L30D with glycerol acetate and purified water evenly to form an enteric coating solution; place the drug-coated pellets in a coating pan, s...

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Abstract

The invention discloses an aspirin enteric-coated pellet which comprises the following components in percentage by weight from inside to outside: 5-22 blank core pellet, 55-75 medicinal layer consisting of aspirin and medicinal excipients and 20-35 enteric-coated layer. The invention also discloses a method for preparing the aspirin enteric-coated pellet and an aspirin enteric-coated capsule containing the aspirin enteric-coated pellets. The aspirin enteric-coated capsule has the advantages of good stability, small stimulation, steady blood concentration, high bioavailability, and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations. Specifically, the invention relates to aspirin enteric-coated pellets and aspirin enteric-coated capsules containing the aspirin enteric-coated pellets. Background technique [0002] Aspirin belongs to non-steroidal antipyretic, analgesic and anti-inflammatory drugs, and has been used in clinical practice for hundreds of years. Over time, aspirin has gradually shifted from its original antipyretic, analgesic, and anti-inflammatory effects to its antithrombotic use. Aspirin inhibits the synthesis of thromboxane TXA2 (Thromboxane) by inhibiting the activity of cyclooxygenase (Cyclo-oxygenase) in platelets, so as to achieve the anticoagulant effect and avoid the occurrence of thrombus. The route of administration of aspirin is mainly oral, and the absorption rate is generally 80%-100%. However, because aspirin has a certain irritation to the stomach, even if the dose is below 300mg, ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/616A61K47/32A61K47/36A61K47/38A61P7/02A61P29/00
Inventor 李芳全苏龙吴保祥
Owner Yung Shin Pharm Ind (Kunshan) Co Ltd
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