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Method for preparing tiny mesoporous silica drug sustained-release material

A technology of silica and slow-release materials, which is applied in the field of material processing and can solve problems such as non-display

Inactive Publication Date: 2014-09-10
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the application of mesoporous hollow materials in the sustained release of drugs has not yet been industrialized, but their good biocompatibility, large internal capacity, pore structure is conducive to sustained release, and the safe transport of encapsulated drugs between cells all show that they are useful as medicines. There is great potential for development in drug sustained-release materials

Method used

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  • Method for preparing tiny mesoporous silica drug sustained-release material
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  • Method for preparing tiny mesoporous silica drug sustained-release material

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Prepare 18wt% cellulose acetate solution. Fill the above solution into a syringe fitted with a metal needle. Connect the positive electrode of the high-voltage power supply to the needle, and the ground electrode to the aluminum film on the collector plate. Adjust the voltage to 20kV, the distance between the needle head and the collecting plate to 20cm, and the liquid feeding speed to 5mL / h, etc., to prepare cellulose acetate electrospun fibers with a diameter of several microns, see attached figure 1 .

[0041] Weigh 0.1 g of cellulose acetate for electrospinning at room temperature, add 45 mL of deionized water and 15 mL of absolute ethanol, then add 0.03 mmol of cetyltrimethylammonium bromide, and then add 0.12 mL of ammonia water as a catalyst. The above mixed solution was dispersed for 30 minutes with an ultrasonic disperser. Let it stand for another 10 minutes to allow CTAB and CAMF to reach adsorption equilibrium. Then 0.6 mL of TEOS dispersed with absolute ...

Embodiment 2

[0045] A 14 wt% cellulose acetate solution was prepared. Fill the above solution into a syringe fitted with a metal needle. Connect the positive electrode of the high-voltage power supply to the needle, and the ground electrode to the aluminum film on the collector plate. Adjust the voltage to 10kV, the distance between the needle and the collecting plate to 10cm, and the liquid feeding speed to 1mL / h, etc., to prepare cellulose acetate electrospun fibers with a diameter of several hundred nanometers. image 3 .

[0046] Weigh 0.1 g of cellulose acetate for electrospinning at room temperature, add 30 mL of deionized water and 30 mL of absolute ethanol, then add 0.3 mmol of cetyltrimethylammonium bromide, and then add 0.9 mL of ammonia water as a catalyst. The above mixed solution was dispersed for 30 minutes with an ultrasonic disperser. Let it stand for another 10 minutes to allow CTAB and CAMF to reach adsorption equilibrium. Then 0.06 mL of TEOS dispersed with absolute ...

Embodiment 3

[0050] A 9wt% cellulose acetate solution was prepared. Fill the above solution into a syringe fitted with a metal needle. Connect the positive electrode of the high-voltage power supply to the needle, and the ground electrode to the aluminum film on the collector plate. Adjust the voltage to 30kV, the distance between the needle and the collecting plate to 15cm, and the liquid feeding speed to 2mL / h, etc., to prepare cellulose acetate electrospinning with a diameter of submicron, see attached Figure 5 .

[0051] Weigh 0.1 g of cellulose acetate for electrospinning at room temperature, add 15 mL of deionized water and 45 mL of absolute ethanol, then add 0.01 mmol of cetyltrimethylammonium bromide, and then add 0.09 mL of ammonia water as a catalyst. The above mixed solution was dispersed for 30 minutes with an ultrasonic disperser. Let it stand for another 10 minutes to allow CTAB and CAMF to reach adsorption equilibrium. Then 0.2 mL of TEOS dispersed with absolute ethanol...

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Abstract

The invention provides a method for preparing a tiny mesoporous silica drug sustained-release material and a tiny mesoporous hollow tubular silicon dioxide material obtained through the method. The drug loading capacity, calculated through a TG method, of the tiny mesoporous hollow tubular silicon dioxide material for aspirin model drugs is 15%, the sustained-release stage is the time of six hours of the initial stage of an experiment, and the drug releasing rate is high; after six hours, the stage of release balancing is achieved, and the amount of balanced release is 73.6%.

Description

technical field [0001] The invention relates to a micro-mesoporous silicon dioxide drug slow-release material, which belongs to the field of material processing. Background technique [0002] There are many porous substances in nature. According to the definition of the International Union of Pure and Applied Chemistry (IUPAC), porous materials (porousmaterial) are divided into three categories according to the pore size range: less than 2nm is micropore (micropore); 2 to 50nm is mesopore (mesopore); greater than 50nm For the macropore (macropore). Sometimes micropores smaller than 0.7nm are called ultramicropores, and macropores larger than 1mm are called macropores. Since Mobil Corporation developed the material represented by M41S in 1992, the ordered mesoporous material really entered the stage as a new material. Ordered mesoporous materials have also attracted scholars in various research fields to conduct in-depth research on them because of their unique structures,...

Claims

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Application Information

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IPC IPC(8): C01B33/12A61K47/04
Inventor 宋君龙
Owner NANJING FORESTRY UNIV
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