Ginkgolide K preparation and preparation method thereof

A technology for ginkgolides and preparations, which is applied in the field of ginkgolide K preparations and its preparation, can solve the problems of small dosage, poor water solubility of ginkgolide K, slow dissolution rate, etc., and achieve fast release rate, low cost, and fast effect

Inactive Publication Date: 2018-03-06
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention makes ginkgolide K into hot-melt extruded capsules, which solves the problems of poor water solubility, slow dissolution rate and small dosage of ginkgolide K, and can improve oral bioavailability and drug compliance of patients

Method used

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  • Ginkgolide K preparation and preparation method thereof
  • Ginkgolide K preparation and preparation method thereof
  • Ginkgolide K preparation and preparation method thereof

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preparation example Construction

[0029] The present invention also provides a kind of preparation method of ginkgolide K capsule, specifically comprises the following steps:

[0030] Step 1. The ginkgolide K of 7.5~15 mass parts, the hydrophilic polymer carrier of 30~75 mass parts, the solubilizer of 5~40 mass parts and the plasticizer and the plasticizer of 2~15 mass parts are fully mixed standby;

[0031] Step 2. Set the extrusion temperature of the screw extruder, start the screw after the temperature rises to the set value, add the physical mixture in step 1 into the extruder, melt and extrude, and extrude in strips , connect the extrudate to a glass plate, after cooling, set aside;

[0032] Step 3. Pulverize the strips obtained in step 2 to obtain drug solid dispersion granules or powder, sieve, and pack into capsules.

[0033] In some specific embodiments of the present invention, step 3 in the preparation is specifically: crush the strip obtained in step 2 through a 30-80 mesh sieve, and pack it into...

Embodiment 1

[0041] Take 15g of ginkgolide K, 75g of polyethylene glycol 6000, 10g of poloxamer and 5g of citrate and mix them fully and uniformly, put them in the hopper, set the temperature of the extruder at 90-100°C, and wait until the temperature rises to After the set value is stable, keep the feeding rate at 15g / min, and add the mixture at a constant speed to obtain a strip-shaped extrudate, cool at 26°C, crush through a 40-mesh sieve, and fill the capsule.

Embodiment 2

[0043] Take 10g of ginkgolide K, 70g of polyethylene glycol 4000, 10g of polysorbate and 10g of polyethylene glycol and mix them fully and uniformly, put them in the hopper, set the temperature of the extruder at 130-140°C, and wait until the temperature rises to the set temperature. After the value is fixed and stable, keep the feeding rate at 15g / min, and add the mixture at a constant speed to obtain a strip-shaped extrudate, cool at 30°C, crush through a 40-mesh sieve, and fill the capsule.

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Abstract

The invention relates to the field of pharmaceutic preparations, in particular to a ginkgolide K preparation and a preparation method thereof. A ginkgolide K hot-melt extruded capsule is prepared fromthe following components in parts by mass: 7.5 to 15 parts of ginkgolide K, 30 to 75 parts of a hydrophilic macromolecular carrier, 5 to 40 parts of a solubilizer and a stabilizer and 2 to 15 parts of a plasticizer. The invention further discloses a preparation method of the ginkgolide K hot-melt extruded capsule. According to the preparation method, the ginkgolide K is prepared into the hot-meltextruded capsule, so that the dissolubility of the ginkgolide K is improved, and the biological utilization degree of oral administration can be increased; the ginkgolide K preparation has the characteristics of small use amount, high product stability, increase of the drug use compliance of a patient and the like.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a ginkgolide K preparation and a preparation method thereof. Background technique [0002] Ginkgolide is an effective substance extracted from the leaves of the Chinese herbal medicine Ginkgo biloba. The substance can be further subdivided into ginkgolides A, B, C, bilobalide, etc. from the structure. For ginkgolides, Chinese patent document CN1195665A introduces A method for extracting ginkgolides and a preparation containing ginkgolides are disclosed. The method is to extract ginkgo leaves by boiling water, adsorb the extraction filtrate with an adsorbent, desorb with ethanol, recover ethanol, dissolve the precipitated crystals, and recrystallize , dried to obtain ginkgolides. The Ginkgolide K described in the invention is a kind of new material (referring to Wang Ying etc., the LC / DAD / ESI / MS analysis and structural identification of the trace component in the Ginkgo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/365A61P9/10
CPCA61K9/4866A61K31/365
Inventor 萧伟胡玉梅孟兆青刘文君杨彪李孟璇房卉李海波黄文哲王振中
Owner JIANGSU KANION PHARMA CO LTD
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