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A temperature-responsive curcumin carrier

A temperature-responsive, curcumin-based technology, which is applied to non-active ingredient medical preparations, ketone active ingredients, and pharmaceutical formulations, can solve the problems of poor controllability of release rate and small temperature response range of drug carriers, and achieve easy Promote, facilitate rapid treatment, and have strong practicability

Active Publication Date: 2021-01-08
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, follow-up studies have found that the temperature response range of the drug carrier is small and the controllability of the release rate is poor.

Method used

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  • A temperature-responsive curcumin carrier
  • A temperature-responsive curcumin carrier
  • A temperature-responsive curcumin carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Experimental part

[0037] 1.1 Drugs:

[0038] Oleyl polyoxyethylene (10) ether (Brij97, purity>99%, Sigma Chemical Company) and Tween40 (chemically pure, Shanghai McLean Biochemical Technology Co., Ltd.), oleic acid (OA, analytically pure, Sinopharm Chemical Reagent Co., Ltd. company), curcumin (purity is 95%, Sinopharm Chemical Reagent Co., Ltd.), and water is twice distilled water.

[0039] 1.2 Preparation of phase diagram

[0040] Pre-mix Brij 97 and Tween 40 at a molar ratio of 1:1, accurately weigh the weight ratio of surfactant (Brij 97 / Tween 40 mixture) and oil phase from 0:10 to 10:0, and place each component in a container with a stopper In a colorimetric tube, stir and mix evenly at a temperature of 60-70°C. Continuously add water phase to the colorimetric tube containing surfactant and oil, the percentage of water is increased at 2% intervals, use a magnetic stirrer to stir evenly, place it in a constant temperature water bath at 25°C to achieve phase ...

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Abstract

The invention provides a curcumin carrier with temperature response. A lyotropic liquid crystal (hexagonal phase and three-dimensional phase) is built in a water medium with non-ionic surfactants (Brij97 and Tween40) and oleic acid to serve as a drug carrier of curcumin. When the temperature of the drug carrier provided by the application rises, the releasing rate of a sample increases, and the highest releasing rate is reached when the temperature of the drug carrier is approximate to the temperature of human body. The drug carrier can be released rapidly after being taken, and facilitates rapid treatment of diseases with drug. Moreover, the carrier has a better slow-releasing effect on the curcumin, and can reduce the taking times of the curcumin.

Description

technical field [0001] The invention belongs to the field of curcumin carriers, in particular to a temperature-responsive curcumin carrier. Background technique [0002] Curcumin is a yellow low molecular weight polyphenolic compound extracted from the rhizome of turmeric. Curcumin has a variety of pharmacological activities, namely anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal and antitumor effects. Despite its potential health benefits to humans, poor water solubility, instability in in vivo and in vitro environments, and extremely low bioavailability of curcumin greatly limit its applications in the food and pharmaceutical industries. [0003] Finding a suitable drug carrier to encapsulate curcumin can effectively improve the shortcomings of curcumin. In the current research, the main drug carriers that have been reported include microcapsules, micelles, microemulsions, complex emulsions, liposomes and lyotropic liquid crystals. Among them, lyotr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/26A61K31/12
CPCA61K9/00A61K31/12A61K47/10A61K47/26
Inventor 王仲妮刘金鹏
Owner SHANDONG NORMAL UNIV
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