Curcumin carrier with temperature response

A temperature-responsive, curcumin technology, applied in non-active ingredients medical preparations, ketone active ingredients, drug delivery, etc., can solve the problems of poor release rate controllability, small temperature response range of drug carriers, etc. The effect of promotion, rapid treatment and strong practicability

Active Publication Date: 2018-08-28
SHANDONG NORMAL UNIV
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, follow-up studies have found that the temperature response range of the drug carrier is small and the controllability of the release rate is poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Curcumin carrier with temperature response
  • Curcumin carrier with temperature response
  • Curcumin carrier with temperature response

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Experimental part

[0037] 1.1 Drugs:

[0038] Oleyl polyoxyethylene (10) ether (Brij97, purity>99%, Sigma Chemical Company) and Tween40 (chemically pure, Shanghai McLean Biochemical Technology Co., Ltd.), oleic acid (OA, analytically pure, Sinopharm Chemical Reagent Co., Ltd. company), curcumin (purity is 95%, Sinopharm Chemical Reagent Co., Ltd.), and water is twice distilled water.

[0039] 1.2 Preparation of phase diagram

[0040] Pre-mix Brij 97 and Tween 40 at a molar ratio of 1:1, accurately weigh the weight ratio of surfactant (Brij 97 / Tween 40 mixture) and oil phase from 0:10 to 10:0, and place each component in a container with a stopper In a colorimetric tube, stir and mix evenly at a temperature of 60-70°C. Continuously add water phase to the colorimetric tube containing surfactant and oil, the percentage of water is increased at 2% intervals, use a magnetic stirrer to stir evenly, place it in a constant temperature water bath at 25°C to achieve phase ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a curcumin carrier with temperature response. A lyotropic liquid crystal (hexagonal phase and three-dimensional phase) is built in a water medium with non-ionic surfactants (Brij97 and Tween40) and oleic acid to serve as a drug carrier of curcumin. When the temperature of the drug carrier provided by the application rises, the releasing rate of a sample increases, and the highest releasing rate is reached when the temperature of the drug carrier is approximate to the temperature of human body. The drug carrier can be released rapidly after being taken, and facilitates rapid treatment of diseases with drug. Moreover, the carrier has a better slow-releasing effect on the curcumin, and can reduce the taking times of the curcumin.

Description

technical field [0001] The invention belongs to the field of curcumin carriers, in particular to a temperature-responsive curcumin carrier. Background technique [0002] Curcumin is a yellow low molecular weight polyphenolic compound extracted from the rhizome of turmeric. Curcumin has a variety of pharmacological activities, namely anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal and antitumor effects. Despite its potential health benefits to humans, poor water solubility, instability in in vivo and in vitro environments, and extremely low bioavailability of curcumin greatly limit its applications in the food and pharmaceutical industries. [0003] Finding a suitable drug carrier to encapsulate curcumin can effectively improve the shortcomings of curcumin. In the current research, the main drug carriers that have been reported include microcapsules, micelles, microemulsions, complex emulsions, liposomes and lyotropic liquid crystals. Among them, lyotr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/26A61K31/12
CPCA61K9/00A61K31/12A61K47/10A61K47/26
Inventor 王仲妮刘金鹏
Owner SHANDONG NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap