Compound control-released percutaneous medicine plaster for treating high blood pressure and its preparation method

Abstract

The invention relates to a compound control-released percutaneous medicine plaster for treating high blood pressure and its preparation method, wherein the paste comprises laminated back lining layer, a pressure-sensitive adhesive framework form medicament-containing layer and a protective film, wherein the compound medicament comprises diuretics, central alpha-acceptor excitant and cirumferential alpha-receptor blocking agent, beta-receptor blocking agent, calcium antagonist and any two of the five categories of medicament for influencing angiotensin II formation and treating high blood pressure. The invention may realize medicine administration once in front of chest or behind the ears, wherein homeostasis blood concentration can be reached.

Description

technical field [0001] The invention belongs to the technical field of drug dosage form design, in particular to a compound transdermal controlled-release patch for treating hypertension and a preparation method thereof. Background technique [0002] At present, there are more than 100 million hypertensive patients in my country, most of which have unknown causes and are a lifelong disease. Long-term and effective implementation of antihypertensive drug therapy is one of the main ways to improve the quality of life and survival rate of hypertensive patients. It has become a consensus in the academic community that hypertensive patients need to use antihypertensive drugs for life. Good control of blood pressure mainly depends on drug effects, adverse drug reactions, patient compliance, and treatment costs. The above aspects are directly related to the success or failure of treatment and the survival of patients. [0003] At present, several types of drugs commonly used in c...

AI Technical Summary

Problems solved by technology

[0014] (1) A single drug can generally only control the blood pressure of 40% to 60% or even less patients, and the effect of severe hypertension is even worse;

[0015] (2) The dose-response curve of commonly used drugs is low and flat, and the effect is not good. When the dose is increased, the curative effect will not increase much, and the side effects will increase logarithmically;

[0020] (3) Concomitant use of drugs can inactivate counter-regulation and mutually limit the adverse compensation induced by another drug;

[0023] However, the medicines currently on the market for the treatment of hypertension are all unilateral pharmaceutical preparations, and the general dosage forms are oral tablets, injections, etc., and as mentioned above, the ideal antihypertensive effect cannot be achieved when the unilateral use is used, although clinicians can treat according to the needs of patients A combination of two or more different medicines is prescribed, but the following treatment defects still exist:

[0024] (1) Quite a few of the above-mentioned drugs for the treatment of hypertension have a large hepatic first-pass effect, and oral administration requires a large dose to achieve effective blood drug concentration, which increases the cost of treatment, but the treatment efficiency is low;

[0025] (2) Oral administration, drug absorption is greatly affected by gastrointestinal factors, drug absorption and metabolism in the body vary greatly among individuals, and the curative effect is uncertain and uncontrollable;

[0026] (3) Frequent administration is required, and the treatment of hypertension is a long-term behavior, which usually requires life-long medication, so the treatment is inconvenient for patients and the compliance is low;

[0027] (4) Based on the above reasons, the dosage of drugs is usually increased to achieve an effective therapeutic effect, but this usually causes relatively large toxic and side effects and increases the incidence of adverse reactions

Because the drug is administered orally, it is often difficult to reverse the toxic and side effects caused by the drug, which will also increase the risk and cost of treatment;

[0028] (5) From the perspective of pharmacoeconomics, the treatment cost of increasing the dose of a single drug is much greater than that of a combination of small doses of drugs

However, oral administration still has some shortcomings such as large dosage, low bioavailability, uncertain curative effect, high incidence of adverse reactions, inconvenient treatment for patients, and poor compliance.

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