3results about How to "Reduce toxic and side effects" patented technology

This invention provides a method and system for cancer subtype identification based on multi-omics data, belonging to the field of bioinformatics processing technology. The method includes: constructing a DILCORE model that integrates a multi-branch variational autoencoder, contrastive learning, and cross-view attention mechanisms. The multi-branch variational autoencoder decomposes omics observation data into common components for subtype classification and view-specific noise components, achieving noise suppression; the InfoNCE contrastive loss is introduced to bring common representations of the same sample closer across different views, enhancing cross-omics consistency; the cross-view residual self-attention mechanism is used to adaptively weight and fuse common vectors; finally, a self-supervised clustering fine-tuning optimization strategy is introduced to jointly improve representation quality and clustering performance in the latent space. This achieves deep and effective integration of multi-omics data, significantly improving the accuracy of cancer subtype identification and providing a powerful tool for personalized cancer treatment and prognostic assessment.

This invention relates to a tofenamic acid liposome, its preparation method, and its application. The raw materials for preparing the tofenamic acid liposome include phospholipids, cholesterol, and tofenamic acid. The tofenamic acid is encapsulated in a lipid bilayer. The tofenamic acid liposome of this invention improves the solubility of tofenamic acid and has a high encapsulation efficiency and drug loading capacity.

The invention discloses a trabectedin-loaded nano-micelle and oxaliplatin-loaded drug combination composition and application, and relates to the technical field of delivery and drug combination, and the trabectedin-loaded nano-micelle and oxaliplatin-loaded drug combination composition comprises trabectedin-loaded nano-micelle and oxaliplatin. The invention also discloses an application of the combined pharmaceutical composition in preparation of antitumor drugs. According to the invention, a pH-sensitive amphiphilic biodegradable material (such as PCL-PEOz) and a chemical drug are self-assembled to form stable micelles, so that the bioavailability of the drug is improved, the critical concentration of the micelles is reduced, and long-acting circulation in vivo is realized; the system can be combined with oxaliplatin for use, so that the sensitivity of tumor cells to oxaliplatin is promoted, the synergistic effect of chemotherapy and immunotherapy is exerted, the treatment effect of malignant tumors is improved, and the tumor microenvironment is improved.