7results about How to "Reduce toxic and side effects" patented technology

The present invention belongs to the field of polypeptide and biomedicine technology, and specifically relates to a polypeptide monomer molecule MBP, polypeptide co-assembled nanoparticles and their applications. The polypeptide co-assembled nanoparticles of the present invention target bacterial outer membrane lipopolysaccharide with the help of the lipopolysaccharide (LPS) targeting unit in the polypeptide monomer molecule MBP, overcome the protective effect of bacterial permeability barrier, and penetrate the membrane to reach the cell; with the help of the thiol oxidase (DsbA) targeting unit in the polypeptide monomer molecule EIP, target the DsbA enzyme in the bacterial cell, strongly bind to the bacterial DsbA enzyme, and transform the nanoparticle state of the polypeptide co-assembled nanoparticles into nanofibers, so that the nanocomposite has a stronger competitive binding ability of the DsbA enzyme, inhibits the activity of the DsbA enzyme, and causes the synthesis of the downstream key enzyme β-lactamase to be blocked, thereby exerting the antibiotic adjuvant effect and realizing the precise delivery of antibiotics.

This invention provides a method and system for cancer subtype identification based on multi-omics data, belonging to the field of bioinformatics processing technology. The method includes: constructing a DILCORE model that integrates a multi-branch variational autoencoder, contrastive learning, and cross-view attention mechanisms. The multi-branch variational autoencoder decomposes omics observation data into common components for subtype classification and view-specific noise components, achieving noise suppression; the InfoNCE contrastive loss is introduced to bring common representations of the same sample closer across different views, enhancing cross-omics consistency; the cross-view residual self-attention mechanism is used to adaptively weight and fuse common vectors; finally, a self-supervised clustering fine-tuning optimization strategy is introduced to jointly improve representation quality and clustering performance in the latent space. This achieves deep and effective integration of multi-omics data, significantly improving the accuracy of cancer subtype identification and providing a powerful tool for personalized cancer treatment and prognostic assessment.

The present invention discloses a targeted nanomaterial having both photodynamic and chemical therapeutic effects, and a preparation method and application thereof. The preparation method comprises the following steps: a first stirring reaction is performed on free TCPP [tetra (carboxyphenyl) porphine] and cisplatin in a mixed system of an organic solution and water, and a TCPP nanosphere loaded with cisplatin is obtained after a first separation and purification; a second stirring reaction is performed on the TCPP nanosphere loaded with cisplatin and a tumor targeting peptide in a buffer system, and an external tumor targeting peptide and a TCPP nanosphere loaded with cisplatin are obtained after a second separation and purification. The TCPP ball-cisplatin-polypeptide of the present invention can give full play to the synergistic effect of the three materials, significantly reduce the toxic and side effects during the treatment process, and improve the tumor treatment effect.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating lung cancer bone metastasis and application thereof. The traditional Chinese medicine composition comprises the following main active ingredients in parts by mass: 20-40 parts of codonopsis pilosula, 20-40 parts of poria cocos, 20-40 parts of astragalus membranaceus, 10-30 parts of bighead atractylodes rhizome, 10-20 parts of liquorice, 10-30 parts of curcuma zedoary, 10-20 parts of pinellia ternate, 5-10 parts of pericarpium citri reticulatae, 20-40 parts of oldenlandia diffusa, 10-30 parts of fructus psoraleae, 10-30 parts of rhizoma drynariae, 10-30 parts of herba epimedii and 10-20 parts of rhizoma arisaematis. Animal experiments show that the traditional Chinese medicine composition not only can inhibit the growth of primary lesion tumors, but also can slow down the progression of bone metastatic lesion tumors, and when the traditional Chinese medicine composition is combined with chemotherapeutics for application, the tumor inhibition effect of the chemotherapeutics can be obviously enhanced, the survival time of mice can be obviously prolonged, and the curative effect of the mice is improved. And weight loss and visceral toxic and side effects caused by chemotherapeutic drugs are relieved.

This invention relates to a tofenamic acid liposome, its preparation method, and its application. The raw materials for preparing the tofenamic acid liposome include phospholipids, cholesterol, and tofenamic acid. The tofenamic acid is encapsulated in a lipid bilayer. The tofenamic acid liposome of this invention improves the solubility of tofenamic acid and has a high encapsulation efficiency and drug loading capacity.

The invention discloses a trabectedin-loaded nano-micelle and oxaliplatin-loaded drug combination composition and application, and relates to the technical field of delivery and drug combination, and the trabectedin-loaded nano-micelle and oxaliplatin-loaded drug combination composition comprises trabectedin-loaded nano-micelle and oxaliplatin. The invention also discloses an application of the combined pharmaceutical composition in preparation of antitumor drugs. According to the invention, a pH-sensitive amphiphilic biodegradable material (such as PCL-PEOz) and a chemical drug are self-assembled to form stable micelles, so that the bioavailability of the drug is improved, the critical concentration of the micelles is reduced, and long-acting circulation in vivo is realized; the system can be combined with oxaliplatin for use, so that the sensitivity of tumor cells to oxaliplatin is promoted, the synergistic effect of chemotherapy and immunotherapy is exerted, the treatment effect of malignant tumors is improved, and the tumor microenvironment is improved.

The present invention relates to Herba Clematidis and an antibacterial composition containing Herba Clematidis extract and application thereof. The present invention provides an application of a composition comprising an antibiotic and Herba Clematidis extract for preventing and / or treating Staphylococcus aureus infection in the preparation of a preparation for preventing and treating Staphylococcus aureus infection. Through extensive research, the present invention unexpectedly discovered that Herba Clematidis has significant antibacterial activity against clinical multidrug-resistant MRSA strains, and can exert an anti-MRSA effect by inhibiting the proliferation of MRSA in the logarithmic growth phase; the antibacterial mechanism of Herba Clematidis extract may be to inhibit the synthesis of certain proteins of the bacteria, thereby inhibiting bacterial growth. Moreover, the test results show that Herba Clematidis extract can also produce a synergistic effect when used in combination with gentamicin. The present invention uses Herba Clematidis extract as a gentamicin enhancer and even in the preparation of antibacterial compositions, which has broad clinical applications and development prospects.