38 results about "Tulobuterol" patented technology

The invention discloses a tulobuterol transdermal patch with a gradient drug release structure and a preparation method of the tulobuterol transdermal patch, belongs to the technical field of transdermal drug delivery systems, and aims at solving the problems that an existing single-layer tulobuterol patch takes effect slowly and is insufficient in later-stage drug release power. The transdermal patch sequentially comprises a backing layer, a gradient medicine-containing substrate layer and an anti-sticking release layer from top to bottom, the gradient drug-containing matrix layer comprises a high-concentration top long-acting drug release layer containing tulobuterol-mesoporous silica nanoparticles and a silicone adhesive, a middle-concentration middle stable drug release layer containing an SIS hot melt adhesive, and a low-concentration bottom quick-acting contact layer containing a specific penetration enhancer composition and an acrylate adhesive from top to bottom in sequence. Through the synergistic effect of bottom-layer penetration promoting driving, middle-layer stable transition and top-layer nanometer storage cavern relay, the traditional concentration barrier is broken through, and rapid effect taking within 1-2 hours and stable-state long-acting drug release within 24 hours or above are perfectly considered.