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Tulobuterol-containing aquogel patch and preparation method thereof

A technology of hydrogel patch and cross-linking agent, which is applied in the field of hydrogel patch containing tulobuterol and its preparation, and can solve the problems of hydrogel matrix hardening, viscosity decrease, cohesion instability, etc.

Inactive Publication Date: 2009-12-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the technical problems that the hydrogel matrix gradually hardens with time, the viscosity decreases, and the cohesion is unstable, and a hydrogel patch containing tulobuterol is provided

Method used

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  • Tulobuterol-containing aquogel patch and preparation method thereof
  • Tulobuterol-containing aquogel patch and preparation method thereof
  • Tulobuterol-containing aquogel patch and preparation method thereof

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preparation example Construction

[0053] The preparation method of hydrogel patch of the present invention, comprises the steps:

[0054] Mix appropriate amount of polymer framework material, crosslinking agent and humectant evenly to obtain phase I;

[0055] Disperse the cross-linking regulator and tulobuterol composed of two or more organic acids in an appropriate amount of distilled water to obtain phase II;

[0056] Mix Phase II and Phase I, stir evenly and then coat.

[0057] Among the two or more organic acids constituting the crosslinking regulator, at least one organic acid is selected from tartaric acid, and at least another organic acid is selected from citric acid, gluconic acid, lactic acid, malic acid, and hydroxysuccinic acid.

[0058] Preferably, phase I also contains fillers and skin penetration enhancers.

[0059] Preferably, the phase II also contains a tackifier, and the tackifier is a methyl vinyl ether / maleic anhydride copolymer.

Embodiment 1

[0061] Embodiment 1 (making 100 tablets of cataplasm altogether)

[0062] Tulobuterol 10g

[0063] Polyacrylic acid / sodium polyacrylate copolymer NP-600 155g

[0064] Methyl vinyl ether / maleic anhydride copolymer 20g

[0065] Polyvinylpyrrolidone K90 10g

[0066] Aluminum hydroxide 2.5g

[0067] Aluminum glycylate 2.5g

[0068] Citric acid 2g

[0069] Tartaric acid 2g

[0070] Glycerin 650g

[0071] Azone 8g

[0072] Distilled water 1400g

[0073] Preparation method: first crush each matrix raw material to a certain fineness, weigh it precisely according to the prescription ratio, and carry out batching, mix polyacrylic acid / sodium polyacrylate copolymer NP-600, aluminum hydroxide, aluminum glycolate, azone, and glycerin Uniformly used as phase I, citric acid, tartaric acid, tulobuterol, methyl vinyl ether / maleic anhydride copolymer, distilled water as phase II were fully dispersed and heated until clear, then phase II was quickly added to phase I and mixed evenly, S...

Embodiment 2

[0075] Embodiment 2 (100 pieces of cataplasms prepared in total)

[0076] Tulobuterol 8g

[0077] Polyacrylic acid / sodium polyacrylate copolymer NP900 125g

[0078] Methyl vinyl ether / maleic anhydride copolymer 16g

[0079] Methylcellulose 2.6g

[0080] Calcium chloride 0.5g

[0081] Aluminum glycylate 2g

[0082] Lactic acid 2.5g

[0083] Tartaric acid 3.5g

[0084] Butanediol 800g

[0085] N-Methylpyrrolidone 10g

[0086] Distilled water 1700g

[0087]The preparation method is the same as in Example 1. The prepared hydrogel patch has good physical properties, the appearance is flat and bright, and the viscosity meets the requirements. The crosslinking time is controlled within 2-4 hours, and the appearance, viscosity, cohesion, etc. have no obvious changes after storage for 6 months. , indicating good stability.

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Abstract

The invention discloses a tulobuterol-containing aquogel patch, which comprises tulobuterol, a macromolecular framework material, a crosslinker, a crosslinking regulator, a humectant and distilled water, wherein the crosslinker is a combination of more than two organic acids; and at least one organic acid is tartaric acid and at least the other organic acid is selected from citric acid, gluconic acid, lactic acid, malic acid and malicaicd. The invention also discloses a method for preparing the tulobuterol-containing aquogel patch. The tulobuterol-containing aquogel patch and the preparation method of the invention make the cohesion of aquogel matrix so stable that the matrix avoids cloth penetration, hardening and other phenomena; the patch is proper in viscosity and insusceptible to falling off after being adhered and can be stripped without causing pains; and the method is controllable in gel time and can meet requirements for industrial large-scale production.

Description

technical field [0001] The invention relates to a patch, in particular to a hydrogel patch containing tulobuterol and a preparation method thereof. Background technique [0002] Tulobuterol (also known as butaclophen), with a chemical name of 1-(o-chlorophenyl)-2-tert-butylaminoethanol, is a selective beta 2 Receptor agonist has a strong and long-lasting effect on expanding bronchial smooth muscle, and is used to relieve bronchial asthma, acute and chronic bronchitis, silicosis, emphysema, pneumoconiosis and other respiratory obstructive symptoms. Tulobuterol is usually administered orally (e.g. using tablets, dry syrup, drop pills, etc.) or inhaled (e.g. using aerosols), but these methods of administration involve the following problems: Difficulty administering to infants , The duration of the drug effect is short, and the side effects such as palpitations and tremors are caused by a sharp increase in the drug concentration in the blood. [0003] Compared with oral prepa...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/137A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61P11/00A61P11/08A61K47/10
Inventor 高申丁雪鹰高静顾圣莹蔡臻侯雪梅丁宝月佟晔张玮陈虹
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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