The invention discloses a temperature-resistant salt-resistant profile control plugging agent and a preparation method thereof. The temperature-resistant salt-resistant profile control plugging agent is prepared from the following raw materials in parts by weight: 1-3 parts of temperature-resistant salt-resistant polyacrylamide, 0.15-1.2 parts of crosslinking agent A, 0.03-0.1 part of crosslinking agent B, 0.01-0.1 part of setting retarder, 1-7.5 parts of pH regulator and 988-997 parts of water. The preparation method comprises the following steps: adding the pH regulator into the water, sufficiently dissolving, adding the temperature-resistant salt-resistant polyacrylamide, stirring for 2-4 hours, adding the setting retarder and crosslinking agent B, stirring at normal temperature for 1-2 hours, adding the crosslinking agent A, stirring uniformly, and standing at the constant temperature of 70-90 DEG C for 3-5 days. The profile control plugging agent has the characteristics of temperature resistance, salt resistance, high gel strength, adjustable gelling time and the like, has selectivity for oily water plugging, and can enter the deep part of the oil reservoir after being injected to plug the high-transmissibility paths, thereby improving the waterflooding development effect and enhancing the recovery ratio of the oil reservoir.