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Percutaneous plaster and its preparation method

A technology for transdermal patches and pressure-sensitive adhesives, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve environmental and human hazards, large equipment investment, and complex production processes. and other problems, to achieve the effect of fast coating speed, high productivity and long storage time

Inactive Publication Date: 2005-01-19
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology uses special materials called acrylic acid esters or other chemical compounds instead of traditional ingredients like alcohols for making pressure sensitive glue products. These substances don't emit any harmful gases during manufacturing processes but they help make them faster dry up quickly overcomes environmental concerns such as volatile emissions from mold release agents used in rubber compositions. They also provide strong cohesion even under very cold conditions. By melting these materials into liquid form before application onto an object being painted, this process allows for easy removal while maintaining good quality paintings.

Problems solved by technology

Technological Problem: Current methods for producing transdermally applied drugs require that they have certain chemical substances mixed with them during their manufacturing processes which can cause environmental concerns over safety issues when released into our environment after use.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0024] Ketoprofen transdermal patch and its preparation:

[0025] Ketoprofen is an aryl alkanoic acid anti-inflammatory and analgesic drug, which has analgesic, anti-inflammatory and antipyretic effects, and is used for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and gout , mostly oral preparations. The Chinese Pharmacopoeia 2000 edition two, the United States Pharmacopoeia USPXXIV edition supplement and the British Pharmacopoeia BP 2000 edition all record its oral tablet or capsule. Due to the irritation of the drug to the gastrointestinal tract, it is of great application value to study its parenteral administration dosage form, among which the research on its transdermal administration is the most.

[0026] Ketoprofen transdermal administration has the following advantages: (1) the medicine acts on the affected part, and the local drug concentration is much higher than the oral blood concentration (it is reported that...

Embodiment 2

[0057] Tulobuterol transdermal patch and preparation method thereof:

[0058] Tulobuterol, also known as tobuterol and clobuterol, is a selective β2-receptor agonist, which has a strong and long-lasting expansion effect on bronchial smooth muscle, but a weak stimulating effect on the heart. It is recorded in the 14th edition of the Japanese Pharmacopoeia. Clinical use shows that this product not only has obvious anti-asthma effects, but also has some anti-asthma and expectorant effects. Generally, it takes effect 5-10 minutes after oral administration, and the effect can last for 4-6 hours. It is mainly used for the prevention and treatment of bronchial asthma and asthmatic bronchitis.

[0059] Tulobuterol was synthesized by Japan Hokuriku Company in 1973. It has a melting point of 89-91°C and a molecular weight of 227.73. The daily oral dose does not exceed 6 mg, which is suitable for transdermal administration. Studies have shown that asthma is most likely to attack betwee...

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Abstract

The invention discloses a percutaneous plaster and its preparation method, wherein the percutaneous plaster comprises a back lining layer, a pressure-sensitive adhesive layer with dissolved medicament of therapeutic effective dose and a antiseizing layer, the pressure-sensitive adhesive being a thermoplastic polymer adhesive agent comprising thermal plasticoelastic bodies, Ketoprofen tulobuterol and traditional Chinese medicinal extract.

Description

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Claims

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Application Information

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Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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