Tulobuterol-containing aquogel patch and preparation method thereof

A technology of hydrogel patch and cross-linking agent, which is applied in the field of hydrogel patch containing tulobuterol and its preparation, and can solve problems such as decreased viscosity, unstable cohesive force, and hardening of the hydrogel matrix
CN101590028BInactive Publication Date: 2011-06-01SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2011-06-01
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a tulobuterol-containing aquogel patch, which comprises tulobuterol, a macromolecular framework material, a crosslinker, a crosslinking regulator, a humectant and distilled water, wherein the crosslinker is a combination of more than two organic acids; and at least one organic acid is tartaric acid and at least the other organic acid is selected from citric acid, gluconic acid, lactic acid, malic acid and malicaicd. The invention also discloses a method for preparing the tulobuterol-containing aquogel patch. The tulobuterol-containing aquogel patch and the preparation method of the invention make the cohesion of aquogel matrix so stable that the matrix avoids cloth penetration, hardening and other phenomena; the patch is proper in viscosity and insusceptible to falling off after being adhered and can be stripped without causing pains; and the method is controllable in gel time and can meet requirements for industrial large-scale production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a patch, in particular to a hydrogel patch containing tulobuterol and a preparation method thereof. Background technique

[0002] Tulobuterol (also known as butaclophen), the chemical name is 1-(o-chlorophenyl)-2-tert-butylaminoethanol, is a selective beta 2 Receptor agonist has a strong and long-lasting effect on expanding bronchial smooth muscle, and is used to relieve bronchial asthma, acute and chronic bronchitis, silicosis, emphysema, pneumoconiosis and other respiratory obstructive symptoms. Tulobuterol is usually administered orally (e.g. using tablets, dry syrup, drop pills, etc.) or inhaled (e.g. using aerosols), but these methods of administration involve the following problems: Difficulty administering to infants , The duration of the drug effect is short, and the side effects such as palpitations and tremors are caused by a sharp increase in the drug concentration in the blood.

[0003] Compared with oral preparat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More