Tulobuterol transdermal patch and preparation method thereof

A transdermal patch, tulobuterol technology, applied in the field of tulobuterol transdermal patch and its preparation, can solve the problems of slow initial transdermal rate, easy crystallization, poor stability of microcrystalline drugs, etc., to achieve The effect of reducing the difficulty of industrial production, excellent stability, and reducing the difficulty of administration

Active Publication Date: 2018-11-23
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the slow initial transdermal rate of microcrystalline tulobuterol drug in the prior art, poor stability of microcrystalline drug, easy crystallization and other problems, the present invention proposes a kind of tulobuterol transder

Method used

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  • Tulobuterol transdermal patch and preparation method thereof
  • Tulobuterol transdermal patch and preparation method thereof
  • Tulobuterol transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The consumption of each raw material is as follows in the present embodiment:

[0044] Drug solution:

[0045]

[0046] Drug storage:

[0047] Drug solution 200mL

[0048] Carbomer 934 25g

[0049] Silicone pressure sensitive adhesive 10g

[0050] Backing film: multi-layer composite aluminum foil.

[0051] Preparation Process:

[0052] Preparation of drug solution: Take polysorbate, isopropanol, oleic acid and tulobuterol according to the prescription amount, dissolve them all under stirring at room temperature, then continue stirring, and add deionized water to the total amount to obtain the drug solution solution.

[0053] Preparation of the drug storage: add the prescribed amount of carbomer to the drug solution prepared above to fully swell, stir at room temperature for 4 hours, and then let it stand overnight; add the prescribed amount of pressure-sensitive adhesive and continue stirring for 2 hours, then coat Cloth the reservoir layer and dry the reservo...

Embodiment 2

[0056] The consumption of each raw material is as follows in the present embodiment:

[0057] Drug solution:

[0058]

[0059] Drug storage:

[0060] Drug solution 200mL

[0061] Carbomer 1342 18g

[0062] Silicone pressure sensitive adhesive 10g

[0063] Backing film: multi-layer composite aluminum foil.

[0064] Preparation of the drug solution: take polysorbate, isopropanol, stearic acid and tulobuterol according to the prescription amount, dissolve them all under stirring at room temperature, then continue to stir, and add deionized water to the total amount, obtain a drug solution;

[0065] Preparation of the drug storage: add the prescribed amount of carbomer to the drug solution prepared above to fully swell, stir at room temperature for 5 hours, and then let it stand overnight; add the prescribed amount of pressure-sensitive adhesive and continue stirring for 3 hours, then coat Cloth the reservoir layer and dry the reservoir layer.

[0066] Tulobuterol patch ...

Embodiment 3

[0068] The consumption of each raw material is as follows in the present embodiment:

[0069]

[0070] Drug storage:

[0071] Drug solution 200mL

[0072] Carbomer 934 20g

[0073] Silicone pressure sensitive adhesive 5g

[0074] Backing film: multi-layer composite aluminum foil.

[0075] Preparation Process:

[0076] Preparation of the drug solution: take polysorbate, isopropanol, oleic acid and tulobuterol according to the prescription amount, dissolve them all under stirring at room temperature, then continue to stir, and add deionized water to the total amount to obtain drug solution;

[0077] Preparation of the drug storage: add the prescribed amount of carbomer to the drug solution prepared above to fully swell, stir at room temperature for 4.5 hours, and then let it stand overnight; add the prescribed amount of pressure-sensitive adhesive and continue stirring for 2.5 hours, then coat Cloth the reservoir layer and dry the reservoir layer.

[0078] Tulobuterol ...

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PUM

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Abstract

The invention relates to a tulobuterol transdermal patch and belongs to the field of transdermal medicinal preparation. According to the tulobuterol transdermal patch disclosed by the invention, tulobuterol is prepared into a drug reservoir; the tulobuterol transdermal patch is prepared from tulobuterol, a penetration enhancer, carbopol and polysiloxane pressure sensitive adhesive; specific matrixcombination and use amount are utilized to for controlling drug release speed, and finally, the purpose of stably releasing drugs for 24 hours is achieved. The tulobuterol transdermal patch is pastedand applied before sleeping, and the plasma concentration can reach peak concentration from late night to early morning when a respiratory function of a patient is prone to reduce; thus, the respiratory function can be improved, a cumulative effect is avoided when the tulobuterol transdermal patch is continuously used, and untoward effects of drugs are reduced. Furthermore, the tulobuterol transdermal patch disclosed by the invention is less affected by environment change, can be stably stored for a long time and can be applied to long-time maintenance therapy of bronchial asthma and chronicobstructive pulmonary disease patients.

Description

technical field [0001] The invention relates to the field of transdermal pharmaceutical preparations, in particular to a tulobuterol transdermal patch and a preparation method thereof. Background technique [0002] Asthma is a common disease of the respiratory system. Its pathogenesis is mainly a chronic airway inflammatory disease caused by the participation of various inflammatory cells such as mast cells, eosinophils, thymic lymphocytes, CD4+T cells, and CD8+T cells. Now there are a variety of drugs for the treatment of asthma, mainly including: glucocorticoids, β2 receptor agonists, theophylline, anticholinergic drugs, leukotriene regulators and so on. Among them, β2 receptor agonists can quickly dilate bronchi to achieve anti-asthma effect, and are commonly used drugs for asthma treatment. Such drugs mainly include quick-acting and short-acting, quick-acting and long-acting, and chronic and long-acting. Tulobuterol is the third generation selective β2 adrenal receptor ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/137A61P11/06A61P11/00
CPCA61K9/7061A61K31/137A61P11/00A61P11/06
Inventor 何淑旺翟光喜景亚军李树英
Owner SHANDONG UNIV
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