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Patch for treating cough and asthma and preparation thereof

A patch and plasticizer technology, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, sheet-like delivery, etc., can solve complex production process, skin damage, low drug transdermal rate, etc. problems, achieve excellent safety and less skin irritation

Inactive Publication Date: 2013-07-17
HENAN LINGRUI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chinese patent ZL96198929.7 uses tulobuterol microcrystals with an average particle size of 2-20um to be suspended in synthetic rubber. This process is complicated to operate, has poor reliability, and requires a large dose of medicine, because the medicine exists in the form of microcrystals. In rubber pressure-sensitive adhesives, the drug transdermal rate is small
This process uses a large dose of medicine, the production process is complicated, and contains a transdermal accelerator, which will damage the skin to a certain extent

Method used

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  • Patch for treating cough and asthma and preparation thereof
  • Patch for treating cough and asthma and preparation thereof
  • Patch for treating cough and asthma and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prescription (based on 1000 stickers): tulobuterol 1.0g, polyethylene glycol 400 2.8g, oleic acid 0.2g, acrylic pressure-sensitive adhesive 36g.

[0019] Process: Dissolve the drug in an appropriate amount of ethanol, add polyethylene glycol 400, oleic acid and acrylic pressure-sensitive adhesive, mix well, coat on the anti-adhesive layer, dry at 60°C, cover the backing layer, punch Cut into 22.4mm×22.4mm, obtain the tulobuterol patch containing 2.5% mass tulobuterol and 0.5% mass oleic acid in the adhesive layer.

Embodiment 2

[0021] Prescription (based on 1000 stickers): tulobuterol 1.0g, polyethylene glycol 400 2.8g, isopropyl myristate 4g, acrylic pressure-sensitive adhesive 32.2g.

[0022] Process: Dissolve the drug in an appropriate amount of ethanol, add polyethylene glycol 400, isopropyl myristate and acrylic pressure-sensitive adhesive, mix well, apply on the release layer, dry at 60°C, and cover the upper back The liner was punched and cut into 22.4mm×22.4mm to obtain a tulobuterol patch containing 2.5% by mass tulobuterol and 10% by mass isopropyl myristate in the adhesive layer.

Embodiment 3

[0024] Prescription (based on 1000 stickers): tulobuterol 1.0g, polyethylene glycol 400 2.8g, polyacrylic resin 4g, acrylic pressure-sensitive adhesive 32.2g.

[0025] Process: Dissolve the drug and polyacrylic acid resin in an appropriate amount of ethanol, add polyethylene glycol 400 and acrylic pressure-sensitive adhesive, mix well, coat on the anti-adhesive layer, dry at 60°C, cover the backing layer, Die into 22.4mm * 22.4mm, obtain the tulobuterol patch that contains 2.5% mass tulobuterol and 10% mass polyacrylic acid resin in the adhesive layer.

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Abstract

The present invention relates to a patch for treating cough and asthma and preparation thereof. The invention provides a tulobuterol patch which is prepared by orderly laminating (a) a support layer, (b) an acrylic pressure-sensitive adhesive agent layer containing a transdermally-absorptive drug of tulobuterol and if needed, a lipophilic oily plasticizer, and (c) a peeling pad. The tulobuterol in the patch can be absorbed transdermally and sustainably release drugs with a drug sustained action of up to twenty-four hours; the patch has a simple formula and a simple preparation process.

Description

technical field [0001] The present invention relates to a tulobuterol patch with bronchodilation effect as an active ingredient, a plasticizer and a transdermal penetration enhancer added to the adhesive layer, and has low skin irritation and excellent safety agent. Background technique [0002] Tulobuterol (also known as butaclophen), chemically named 1-(o-chlorophenyl)-2-tert-butylaminoethanol, is a selective beta 2 Receptor agonist has a strong and long-lasting expansion effect on bronchial smooth muscle, and is used to relieve symptoms of airway obstruction such as bronchial asthma, acute and chronic bronchitis, silicosis, emphysema, and pneumoconiosis. [0003] Asthma is a chronic respiratory disease accompanied by symptoms such as shortness of breath, wheezing, wheezing, phlegm, and chest tightness. The approach to asthma treatment is to use long-acting controller medications to maintain control of persistent asthma, and rapid-relief medications to manage symptoms an...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/137A61K47/32A61P11/08A61P11/14A61P11/06
Inventor 熊维政张军兵武惠斌卢玉斌聂红梅汪平
Owner HENAN LINGRUI PHARMA
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