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Percutaneous-absorption tulobuterol controlled release patch and preparation method thereof

An adhesive and adhesive technology, applied in the field of tulobuterol patch preparation, can solve the problems of increased blood drug concentration, poor skin permeability, difficulties, etc., and achieve long release time, improved curative effect, and stable release speed Effect

Active Publication Date: 2018-07-03
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Tulobuterol is usually administered orally or inhaled, but these two methods have some problems: it is difficult to administer tulobuterol to infants or a small number of elderly people, and it is easy to cause a sharp increase in blood drug concentration and cause side effects. Drugs can effectively solve problems such as drug administration difficulties, and can have a longer duration of drug effect
The known tulobuterol transdermal patch technology mostly uses acrylate adhesives, which has low drug loading, poor skin permeability, and unsatisfactory steady-state sustained release effect

Method used

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  • Percutaneous-absorption tulobuterol controlled release patch and preparation method thereof
  • Percutaneous-absorption tulobuterol controlled release patch and preparation method thereof
  • Percutaneous-absorption tulobuterol controlled release patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription:

[0025]

[0026] experiment procedure

[0027] Take OppanolB 15 SFN, OppanoiB 10 N, polybutene, resin, and tulobuterol in the above-mentioned prescription respectively, add n-hexane to dissolve in a round bottom flask, reflux at 100°C±10°C for 5h, lay a film, and dry naturally .

Embodiment 2

[0029] prescription:

[0030]

[0031] experiment procedure

[0032] Take OppanolB 15 SFN, OppanoiB 10 N, polybutene, resin, and tulobuterol in the above-mentioned prescription respectively, add n-hexane to dissolve in a round-bottomed flask, reflux at 100°C±10°C for 1 hour, lay a film, and dry naturally .

Embodiment 3

[0034] prescription:

[0035]

[0036] experiment procedure

[0037] Take OppanolB 15 SFN, OppanoiB 10 N, polybutene, resin, and tulobuterol in the above-mentioned prescription quantities respectively, add n-hexane to dissolve in a round-bottomed flask, lay a film, and let it dry naturally.

[0038] Pharmacological experiment

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PUM

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Abstract

The invention relates to a percutaneous-absorption patch utilizing an anti-asthma drug tulobuterol as an active component. The tulobuterol patch can be prepared by the steps of dissolving tulobuterol,a pressure-sensitive adhesive and a film-forming agent into a good solvent, heating for reflux, uniformly coating a back lining with the mixture by virtue of a coating device, and drying so as to obtain the tulobuterol patch. The tulobuterol patch is characterized in that a percutaneous absorption preparation is capable of continuously controlling the release of tulobuterol and simultaneously hasthe characteristics that the storage stability is long, and tulobuterol is not formed in a drug layer. According to the method provided by the invention, the tulobuterol patch can be effectively produced.

Description

Technical field: [0001] The invention relates to a tulobuterol controlled-release patch for percutaneous absorption by applying medicine to the skin surface so that the drug tulobuterol continuously enters the body to exert its drug effect. The adhesive of the patch is made of polyisobutylene pressure-sensitive A mixture of glue and petroleum resin. The invention also relates to a preparation method of the tulobuterol patch. The patch maintains a continuous approximately constant rate of transdermal administration of tulobuterol for 24 hours. Background technique: [0002] Tulobuterol is a selective β2-receptor agonist, which has a strong and long-lasting expansion effect on bronchial smooth muscle, but a weak stimulating effect on the heart. Experiments on isolated animals have shown that this product relaxes bronchial smooth muscle 2-10 times as fast as Chloroprenaline, while its stimulating effect on the heart is 1 / 1000 that of isoproterenol, and the duration of action ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/137A61K47/06A61P11/06A61P11/14
CPCA61K47/06A61K9/7023A61K31/137
Inventor 郑稳生谭晓川张宇佳王璐璐
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI