Tulobuterol adhesive patch

一种妥洛特罗、贴剂的技术，应用在妥洛特罗贴剂领域，能够解决未发现等问题，达到皮肤刺激性小、安全性优异、粘合特性优异的效果

Inactive Publication Date: 2007-01-31
NIPRO PATCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been found that in an acrylic pressure-sensitive adhesive layer comprising a copolymer containing acetoacetoxyalkyl (meth)acrylate as one of the constituting monomers, a percutaneously absorbable drug is incorporated. Patch literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Weigh 35.69g of the non-aqueous acrylic pressure-sensitive adhesive prepared in the adhesive manufacturing example and add it to the screw bottle, then weigh 3.0g isopropyl myristate and 1.5g tulobuterol respectively This was added and stirred for 1 hour. Using a coating tester (LTE-S, Wener Mathis Co.), coat and dry a polyester film so that the mass of the dried film becomes 20 mg / 10 cm 2 Afterwards, the silicone treatment surface of the polyester release liner that has been subjected to silicone treatment on one side is in contact with the adhesive to cover, and the adhesive layer contains 10% by mass tulobuterol and 20% by mass. Tulobuterol patch of Example 1 of isopropyl myristate.

Embodiment 2

[0050] Use 1.5g of tulobuterol, 38.69g of the non-aqueous acrylic pressure-sensitive adhesive obtained in the adhesive manufacturing example, do not use isopropyl myristate, and operate in the same way as Example 1 except that , obtain the tulobuterol patch of embodiment 2 that contains 10% quality tulobuterol in the adhesive layer.

Embodiment 3

[0052] Use 40.0g of non-aqueous acrylic pressure-sensitive adhesives, 0.5g tulobuterol, and 3.0g isopropyl myristate prepared in the adhesive manufacturing example, and utilize the same method as in Example 1 to make The mass of the film becomes 67mg / 10cm 2 Carry out operation, obtain the tulobuterol patch of embodiment 3 that contains 3% mass tulobuterol and 20% mass isopropyl myristate in the adhesive layer.

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PUM

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Abstract

A tulobuterol adhesive patch which comprises (a) a substrate, (b) an acrylic pressure-sensitive adhesive layer containing tulobuterol which is a percutaneously absorbable drug and optionally further containing a plasticizer comprising an oleophilic oily matter, and (c) a release liner superposed on the adhesive layer, wherein the acrylic pressure-sensitive adhesive comprises a copolymer obtained by copolymerizing an acrylic monomer which is an acetoacetoxyalkyl (meth)acrylate with one or more other vinyl monomers. Due to the use of the copolymer, the tulobuterol adhesive patch is excellent in tulobuterol releasability from the pressure-sensitive adhesive layer and tulobuterol permeation through the skin, is reduced in skin irritation, and is highly safe.

Description

technical field [0001] The present invention relates to the use of tulobuterol, which has a bronchodilatory effect, as an active ingredient, and the use of a copolymer containing acetoxyalkyl (meth)acrylate as one of the constituent monomers in an adhesive layer. Tulobuterol patch with acrylic pressure sensitive adhesive. Background technique [0002] A patch containing tulobuterol as a sympathetic β2 receptor selective agonist in an adhesive layer mainly composed of a synthetic rubber adhesive is known (for example, refer to Patent Document 1). A patch containing tulobuterol in an adhesive layer mainly composed of an acrylic pressure-sensitive adhesive is also known (for example, refer to Patent Document 2). [0003] In the case of a patch containing tulobuterol in a synthetic rubber-based adhesive, since the crystals of tulobuterol are dispersed in the adhesive layer, the release of tulobuterol from the adhesive layer is sustained, However, there are problems of poor ini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61K9/70A61K47/10A61K47/14A61K47/32A61P43/00
CPCA61K31/137A61K9/7061A61P11/06A61P11/08A61P43/00
Inventor 川村尚久泽田英范杉崎良树斋藤隆
Owner NIPRO PATCH
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