Econazole nitrate microemulsion aerosol and method for preparing same

A technology of econazole nitrate and aerosol, which is applied in aerosol delivery, antifungal agents, pharmaceutical formulations, etc. It can solve the problems of repeated attacks, improve absorption, reduce toxic and side effects, and increase bioavailability Effect

Inactive Publication Date: 2009-09-02
周小萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Studies at home and abroad have shown that econazole nitrate is a broad-spectrum antifungal drug, which has bactericidal and bacteriostatic effects on dermatophytes, yeasts, biphasic fungi, and aspergillus. The drug of choice for superficial fungal infections such as tinea versicolor and candidal dermatitis. However, although econazole nitrate is effective in the treatment of gynecological diseases such as mold and candidal vaginitis, it has a recurrent phenomenon, so , how to make econazole nitrate act for a long time and have a thorough therapeutic effect has become an urgent research topic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Take econazole nitrate 0.1g, polyethylene glycol-400 4g, sodium lauryl sulfate 1, and an appropriate amount of purified water, stir at 73°C until completely dissolved, and set aside;

[0023] (2) Take polysorbate-80 1g, octylphenol polyoxyethylene ether-10 1g, imidazoline 0.5, dioctyl sodium sulfosuccinate 2, stir at room temperature until completely dissolved, set aside;

[0024] (3) Take 0.3g of sodium lauryl sulfate, 0.2g of coconut oil fatty acid diethanolamide, 1.5g of glycerol polyoxyethylene castor oil, and an appropriate amount of purified water, stir evenly at 68°C until completely dissolved, and set aside;

[0025] (4) After mixing the solutions obtained in steps (1), (2) and (3), stir evenly at room temperature for 20 minutes to obtain colostrum;

[0026] (5) Homogenization: After the colostrum is passed through a 0.80 μm filter membrane, it is passed through a nanomachine and then passed through a 0.22 μm filter membrane;

[0027] (6) filling, filling 1...

Embodiment 2

[0029] (1) Take 0.9g of econazole nitrate, 9g of polyethylene glycol-400, 5g of sodium lauryl sulfate, and an appropriate amount of purified water, stir at 78°C until completely dissolved, and set aside;

[0030] (2) Take 4g of polysorbate-80, 7g of octylphenol polyoxyethylene ether-10, 4g of imidazoline, and 3g of sodium dioctyl succinate sulfonate, stir at room temperature until completely dissolved, and set aside;

[0031] (3) Take 1 g of sodium lauryl sulfate, 2 g of coconut oil fatty acid diethanolamide, 1.5 g of glycerol polyoxyethylene castor oil, and an appropriate amount of purified water, stir evenly at 75°C until completely dissolved, and set aside;

[0032] (4) After mixing the solutions obtained in steps (1), (2) and (3), stir evenly at room temperature for 30 minutes to obtain colostrum;

[0033] (5) Homogenization: After the colostrum is passed through a 0.80 μm filter membrane, it is passed through a nanomachine and then passed through a 0.22 μm filter membrane...

Embodiment 3

[0036] (1) Take 6g of econazole nitrate, 15g of polyethylene glycol-400, 7g of sodium lauryl sulfate, and an appropriate amount of purified water, stir at 75°C until completely dissolved, and set aside;

[0037] (2) Take polysorbate-80 5g, octylphenol polyoxyethylene ether-10 5g, imidazoline 10g, dioctyl sodium sulfosuccinate 5g, stir at room temperature until completely dissolved, and set aside;

[0038] (3) Take 7g of sodium lauryl sulfate, 5g of coconut oil fatty acid diethanolamide, 3.5g of glycerol polyoxyethylene castor oil, and an appropriate amount of purified water, stir evenly at 70°C until completely dissolved, and set aside;

[0039] (4) After mixing the solutions obtained in steps (1), (2) and (3), stir evenly at room temperature for 25 minutes to obtain colostrum;

[0040] (5) Homogenization: After the colostrum is passed through a 0.80 μm filter membrane, it is passed through a nanomachine and then passed through a 0.22 μm filter membrane;

[0041] (6) filling,...

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PUM

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Abstract

The invention relates to an econazole nitrate microemulsion aerosol and a method for preparing the same. The aerosol is prepared by the materials mainly comprising econazole nitrate, polyethylene glycol 400, polysorbate 80, octane pheno1 polyoxyethylene 10, imidazoline, sodium lauryl sulfate, coconutt diethanol amide, sodium laureth sulfate, dioctyl sulfosuccinate sodium salt, polyoxyethylenated castor oil, purified water, and propane and butane. The method for preparing the aerosol comprises the following steps: dissolving the materials under different conditions; uniformly stirring the solution obtained after dissolution to obtain a primary emulsion; passing the primary emulsion first through a 0.80 mu m of filter membrane, then a nanomachine, and finally a 0.22 mu m of filter membrane; and filling, filling propane-butane projectile and sealing to obtain the finished product of econazole nitrate nanometer microemulsion aerosol.

Description

technical field [0001] The invention relates to a microemulsion aerosol of econazole nitrate for treating gynecological diseases and a preparation method thereof, in particular to a new type of nitric acid which is non-toxic, safe, efficient and convenient to use for treating gynecological diseases Econazole nanoscale microemulsion aerosol and preparation method thereof. Background technique [0002] At present, women's vaginitis, cervicitis and cervical erosion and other gynecological reproductive tract infection diseases have become the main diseases that endanger the health of modern women. Faced with many problems that need to be solved in the field of reproductive health, people regard the prevention and treatment of reproductive tract infection as an important part of reproductive health. social and economic burden, and a major threat to human health. With the excessive and uncontrolled use of antibiotics, some antibiotics that were originally extremely lethal to bac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/4174A61K47/44A61P31/10A61P15/02
Inventor 周小萍林文辉周国良蒋宇亮林柳清
Owner 周小萍
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