Patch of abstention containing cola stationary medicament and preparing method thereof

A clonidine and patch technology, applied in non-active ingredients medical preparations, drug combinations, pharmaceutical formulations, etc., can solve problems such as addictive drugs, and achieve stable process, good reproducibility, and reduced individual differences. Effect

Inactive Publication Date: 2008-06-18
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the disadvantages of opioid drug detoxification therapy in the prior art that produces euphoria, is easy to become addicted, and cannot make the drug enter the human body at a constant rate for a long time, and provides a long-acting, Drug detoxification patches containing clonidine that are absorbed by the skin, not easily addicted, act quickly, have a high success rate of cure, and are easy to carry and use

Method used

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  • Patch of abstention containing cola stationary medicament and preparing method thereof
  • Patch of abstention containing cola stationary medicament and preparing method thereof
  • Patch of abstention containing cola stationary medicament and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Under the clean conditions that meet the pharmaceutical requirements, the preparation is carried out according to the prescription and process in the table below.

[0019] Embodiment 1 prescription composition

[0020]

[0021] The backing layer is PET film, the protective layer is PET film after anti-adhesive treatment, the release-controlling film is EVA polymer film, and the drug storage layer and adhesive layer are composed of clonidine, pressure-sensitive adhesive and penetration enhancer. The total area of ​​the patch is 2.5cm 2 , Each tablet contains 2.5mg of clonidine. The shape is a rectangle of 2.5cm×1.0cm.

[0022] Preparation process: mainly includes: pulping, coating, compounding, cutting, internal and external packaging, etc.

[0023] (1) The technological process is as follows:

[0024]

[0025] (2) Drug-containing glue preparation process of drug storage layer and viscose layer

[0026] Dissolve the polyacrylate with cyclohexane before compoun...

Embodiment 2

[0031] Under the clean conditions that meet the pharmaceutical requirements, the preparation is carried out according to the prescription and process in the table below.

[0032] Embodiment 2 prescription composition

[0033]

[0034] The preparation process is as in Example 1.

[0035] How to use this patch:

[0036] Stick it on the arm, chest or other convenient skin parts, and each stick can be used continuously for 5 days. Dosage and treatment plan: It should be adjusted according to the patient's age, weight, health status, drug use history, severity of withdrawal symptoms and side effects after medication, and the number of patches can be removed or increased at any time. The daily permeation amount of each patch is calculated as 200ug, and the maximum permeation amount during detoxification is preferably 14-17ug / kg / day.

[0037] Take a 50-60kg person for detoxification as an example: 4 patches are applied at the same time on the 1st to 4th day, and 3 new patches a...

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Abstract

The invention discloses a detoxification plaster with clonidine and the related preparation method used for curing opioid and tobacco-dependentance. The detoxification plaster is structurally composed of a protective layer, an adhesive layer, a control release membrane layer, a medicine storehouse layer and a back lining layer. The ingredients of the preparation are that: the medicine storehouse layer contains 10 to 40 percent of clonidine and 0 to 20 percent of transdermal enhancer and the rest are soluble or non-soluble substrates; the adhesive layer contains 0 to 30 percent of clonidine and 2 to 20 percent of transdermal enhancer and the rest is pressure-sensitive adhesive; the back lining layer is a PET membrane or a non-woven fabric; the protective layer is a PET film processed with antisticking treatment; the control release membrane is an EVA polymer membrane. The area of each plaster is 1-5square centimeters; each plaster contains 1mg to 5mg of clonidine. The invention is not addictive but fast in effect, high in cure rate and safe and convenient. The external release of the invention reaches zero-degree rate process.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating opium and tobacco dependence and a preparation method thereof. Specifically, it is a detoxification patch containing clonidine and a preparation method thereof. Background technique [0002] Clonidine is an imidazoline derivative synthesized in the early 1960s, belonging to α 2 Adrenergic receptor agonists, and its tablets are widely used clinically as antihypertensive drugs. In the 1980s, the detoxification, analgesic and sedative effects of clonidine have attracted great attention. The study found that during the withdrawal period of opioid addicts, the adrenergic neurons of the coeruleus coeruleus increased the impulse speed, the release of norepinephrine caused by each impulse increased, and the norepinephrine spillover also increased. Clonidine activates presynaptic alpha 2 receptor, feedback inhibits norepinephrine release, thereby inhibiting highly active locus coeruleus adre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4168A61K47/32A61P25/36
Inventor 梁炳文高建义梁涛梁友
Owner TIANJIN ZHONGBAO PHARMACY
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