Patch of abstention containing cola stationary medicament and preparing method thereof

A clonidine and patch technology, applied in non-active ingredients medical preparations, drug combinations, pharmaceutical formulations, etc., can solve problems such as addictive drugs, and achieve stable process, good reproducibility, and reduced individual differences. Effect
CN101199495AInactive Publication Date: 2008-06-18TIANJIN ZHONGBAO PHARMACY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN ZHONGBAO PHARMACY
Publication Date
2008-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a detoxification plaster with clonidine and the related preparation method used for curing opioid and tobacco-dependentance. The detoxification plaster is structurally composed of a protective layer, an adhesive layer, a control release membrane layer, a medicine storehouse layer and a back lining layer. The ingredients of the preparation are that: the medicine storehouse layer contains 10 to 40 percent of clonidine and 0 to 20 percent of transdermal enhancer and the rest are soluble or non-soluble substrates; the adhesive layer contains 0 to 30 percent of clonidine and 2 to 20 percent of transdermal enhancer and the rest is pressure-sensitive adhesive; the back lining layer is a PET membrane or a non-woven fabric; the protective layer is a PET film processed with antisticking treatment; the control release membrane is an EVA polymer membrane. The area of each plaster is 1-5square centimeters; each plaster contains 1mg to 5mg of clonidine. The invention is not addictive but fast in effect, high in cure rate and safe and convenient. The external release of the invention reaches zero-degree rate process.
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Description

technical field

[0001] The invention relates to a pharmaceutical preparation for treating opium and tobacco dependence and a preparation method thereof. Specifically, it is a detoxification patch containing clonidine and a preparation method thereof. Background technique

[0002] Clonidine is an imidazoline derivative synthesized in the early 1960s, belonging to α 2 Adrenergic receptor agonists, and its tablets are widely used clinically as antihypertensive drugs. In the 1980s, the detoxification, analgesic and sedative effects of clonidine have attracted great attention. The study found that during the withdrawal period of opioid addicts, the adrenergic neurons of the coeruleus coeruleus increased the impulse speed, the release of norepinephrine caused by each impulse increased, and the norepinephrine spillover also increased. Clonidine activates presynaptic alpha 2 receptor, feedback inhibits norepinephrine release, thereby inhibiting highly active locus coeruleus adre...

Claims

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