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A kind of capsule preparation containing tegafur, gemesta and oxonate potassium and preparation method thereof

A technology of potassium oxonate and tegafur, applied in the field of medicine, can solve problems such as poor water solubility and instability, and achieve the effects of fast dissolution rate, stable dissolution rate and improved stability.

Active Publication Date: 2011-12-21
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tegafur is an alkaline drug with poor water solubility and shows instability in acidic solution

Method used

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  • A kind of capsule preparation containing tegafur, gemesta and oxonate potassium and preparation method thereof
  • A kind of capsule preparation containing tegafur, gemesta and oxonate potassium and preparation method thereof
  • A kind of capsule preparation containing tegafur, gemesta and oxonate potassium and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 The preparation of this Fategafur, gemesta and oxonate potassium capsule preparations:

[0045] Name of raw material Amount / g

[0046] Prescription for tegafur pellets:

[0047] Tegafur 20

[0048] Microcrystalline Cellulose 22

[0049] Appropriate amount of purified water

[0050] Prescription of gemesstat pellets:

[0051] Gimesta 5.25

[0052] starch 10

[0053] Appropriate amount of purified water

[0054] Prescription of gemesstat pellets:

[0055] Potassium oxonate 15..5

[0056] Starch 15

[0057] Appropriate amount of purified water

[0058] other:

[0059] Sodium p-dodecylbenzenesulfonate 10

[0060] A total of 1000 capsules were made

[0061] Preparation Process:

[0062] (1) Pass tegafluoride through a 100-mesh sieve, add auxiliary materials and mix evenly, add an appropriate amount of purified water to prepare soft materials, use a 20-mesh screen to make granules with suitable humidity; put the granules in a shot blasting machine, ...

Embodiment 2

[0065] Embodiment 2 The preparation of this Fategafur, gemesta and oxonate potassium capsule preparations:

[0066] Name of raw material Amount / g

[0067] Prescription for tegafur pellets:

[0068] Tegafur 25

[0069] Microcrystalline Cellulose 20

[0070] 2% HPMC aqueous solution appropriate amount

[0071] Prescription of gemesstat pellets:

[0072] Guimesta 7.25

[0073] Microcrystalline Cellulose 12

[0074] 2% HPMC aqueous solution appropriate amount

[0075] Prescription of gemesstat pellets:

[0076] Potassium oxonate 24.5

[0077] Microcrystalline Cellulose 14

[0078] 2% HPMC aqueous solution appropriate amount

[0079] other:

[0080] Sodium Lauryl Sulfate 15

[0081] A total of 1000 capsules were made

[0082] Preparation Process:

[0083] (1) Pass tegafur through a 100-mesh sieve, add auxiliary materials and mix evenly, add an appropriate amount of 2% HPMC aqueous solution to prepare a soft material, use a 20-inch screen, and extrude strips with a len...

Embodiment 3

[0086] Embodiment 3 The preparation of this Fategafur, gemesta and oxonate potassium capsule preparations:

[0087] Name of raw material Amount / g

[0088] Prescription for tegafur pellets:

[0089] Tegafur 25

[0090] Pregelatinized starch 15

[0091] Lactose 12

[0092] 3% HPMC aqueous solution appropriate amount

[0093] Prescription of gemesstat pellets:

[0094] jimmiesta 7

[0095] pregelatinized starch 4

[0096] Lactose 3

[0097] 3% HPMC aqueous solution appropriate amount

[0098] Prescription of Potassium Oxonate Potassium Pellets:

[0099] Potassium oxonate 18

[0100] pregelatinized starch 10

[0101] Lactose 6

[0102] 3% HPMC aqueous solution appropriate amount

[0103] other:

[0104] Sodium Lauryl Sulfate 16

[0105] A total of 1000 capsules were made

[0106] The preparation process is the same as in Example 2.

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Abstract

The invention relates to a capsule preparation containing tegafur, gemestat and oxonate potassium and a preparation method thereof, which is characterized in that the capsule preparation contains tegafur pellets, gemesta pellets and oxonate potassium pellets , wherein the pellets are composed of active pharmaceutical ingredients, diluents, binders and surfactants; the pellets are prepared by extrusion-spheronization method, centrifugal-fluidization method and coating pot pan-pellet method, and then other excipients are added, Finally the capsules are filled. The capsule prepared by the invention can release the drug stably and quickly in the body, improves the stability of the drug, has better dissolution rate and bioavailability, and reduces the adverse reaction of the drug.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pellet capsule preparation containing three kinds of medicines, tegafur, gemesstat and potassium oxonate, and a preparation method thereof. Background technique [0002] Tegafur (FT, FT207) is one of the pyrimidine anticancer drugs. It is the prodrug of 5-fluorouracil (5-FU), and has inhibitory effect on most solid tumors. In the body, it can interfere and block the biosynthesis of DNA, RHA and protein, thereby producing its anticancer effect. Basic medical research and clinical observation have proved that tegafur has less toxic and side effects, higher chemotherapy index, less effect on immunosuppression and related immune organs, and is a safe drug that can be used continuously in clinical practice. This product is absorbed through the gastrointestinal tract after oral administration, and the blood concentration reaches the highest peak within 1-3 hours. The d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/513A61K31/4412A61K9/48A61K31/53A61P35/00A61K47/40
Inventor 赵志全郝贵周
Owner LUNAN PHARMA GROUP CORPORATION
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