Pulse-promoting slow-release capsule and preparing method

A technology for sustained-release capsules and pulse regeneration, which can be used in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. Effect

Inactive Publication Date: 2011-08-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. It is not advisable to take it with cold medicine at the same time
4. It is not advisable to take veratrum and its preparations while taking the medicine
10. Children must be used under adult supervision

Method used

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  • Pulse-promoting slow-release capsule and preparing method
  • Pulse-promoting slow-release capsule and preparing method
  • Pulse-promoting slow-release capsule and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prescription: Ginseng 100g, Ophiopogon japonicus 200g, Schisandra chinensis 100g, microcrystalline cellulose 100g, hollow capsule 65% ethanol solution

[0038] Preparation method:

[0039] The process route is as follows

[0040]

[0041] The ginseng, Ophiopogon japonicus and Schisandra chinensis are washed, crushed, soaked in 65% ethanol solution for 24 hours, and then subjected to wet treatment, and the obtained extract is spray-dried at 5-7ml / min to obtain a drug dry powder. The microcrystalline cellulose and the dry drug powder were put into a coating pan with a rotational speed of 15r / min, and 500g of dry pellets were obtained at 40°C and 10r / min. Pack into capsules to get 1000 capsules.

[0042] After testing, it contains ginsenoside Rg 1 , Re total content accounts for 0.25%, ophiopogon saponin B, D total content accounts for 0.25%, schisandra alcohol A content accounts for 0.30%.

Embodiment 2

[0044] Prescription: Ginseng 100g, Ophiopogon japonicus 200g, Schisandra chinensis 100g, hypromellose 120g, hollow capsule, 65% ethanol solution

[0045] Preparation method:

[0046] The process route is as follows

[0047]

[0048] Wash the ginseng, Ophiopogon japonicus and Schisandra chinensis, crush them, soak them in 65% ethanol solution for 24 hours, and then carry out wet treatment to obtain the extract. Put the hypromellose into the coating pan, spray the extract at a rate of 5-7ml / min at 40°C, and obtain 500g of skeleton pellets after drying. Pack into capsules to get 1000 capsules.

[0049] After testing, it contains ginsenoside Rg 1 , Re total content accounts for 0.25%, ophiopogon saponin B, D total content accounts for 0.35%, schisandra alcohol A content accounts for 0.30%.

Embodiment 3

[0051] Adopt embodiment 1 or 2 to prepare the technique of matrix pellet, different slow-release materials such as methyl cellulose (MC), hypromellose (HPMC), povidone (PVP), ethyl cellulose, cellulose acetate 1. Polymethacrylate 80-100g, prepare 500g of skeleton-type pellets, and then pack into capsules to obtain 1000 capsules. Its detection result is basically identical with embodiment 1,2.

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PUM

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Abstract

The invention is a pulse-activating sustained-release capsule and the preparing method thereof, belonging to the field of traditional Chinese medicine and preparing method, using gen-seng, Dwarf Lilyturf Tuber and Chinese Magnoliavine Fruit as raw medicinal materials, and obtaining extract by alcohol soaking and seeping processing; making the extract and sustained-release material into framework or coated pellets, and then putting the pellets in a hollow capsules so as to make a dispersive dosage sustained-release capsule. It can keep in-blood medicine concentration for long time; prolong curative effect and reduce toxicity and side effect, especially applied to patients suffering chronic diseases in need of long-time taking medicine, such as patients suffering from chronic lung-source heart disease.

Description

technical field [0001] The invention belongs to the field of a traditional Chinese medicine and a preparation method thereof, in particular to a Chinese patent medicine slow-release capsule for treating chronic pulmonary heart disease and a preparation method thereof. Background technique [0002] It is mentioned in the book "Medical Origin": Shengmaisan treats symptoms caused by warm heat and summer heat, consuming qi and hurting yin, or old cough and lung deficiency, caused by both qi and yin injuries. Because summer heat is a yang evil, hot steaming and sweating are more likely to consume qi and damage body fluid, resulting in both qi and yin damage, so sweating, mental fatigue, body fatigue, shortness of breath, dry throat, and weak pulse. The above symptoms can also be seen in those who have long-term lung injury and insufficient Qi and Yin when coughing. The treatment is suitable for the method of nourishing qi, nourishing yin and promoting body fluid. The ginseng in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K9/48A61P11/00A61P9/00
Inventor 滕利荣高波孟庆繁王贞佐王博
Owner JILIN UNIV
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