Pulse-promoting slow-release capsule and preparing method

A technology for sustained-release capsules and pulse regeneration, which can be used in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. Effect

Inactive Publication Date: 2006-08-09
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. It is not advisable to take it with cold medicine at the same time
4. It is not advisable to take ve

Method used

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  • Pulse-promoting slow-release capsule and preparing method
  • Pulse-promoting slow-release capsule and preparing method
  • Pulse-promoting slow-release capsule and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prescription: 100g of ginseng, 200g of Ophiopogon japonicus, 100g of schisandra, 100g of microcrystalline cellulose, hollow capsules

[0038] 65% ethanol solution

[0039] Preparation method:

[0040] The process route is as follows

[0041]

[0042] The ginseng, Ophiopogon and Schisandra are washed, crushed, and soaked in a 65% ethanol solution for 24 hours, and then subjected to wet treatment. The extract is spray-dried at 5-7 ml / min to obtain a dry powder of the medicine. Put the microcrystalline cellulose and the drug dry powder into a coating pan with a rotation speed of 15 r / min, and obtain 500 g of dry pellets at 40° C. and 10 r / min. Put it into capsules to get 1000 capsules.

[0043] After testing, it contains ginsenoside Rg 1 The total content of Re is 0.25%, the total content of Ophiopogon saponins B and D accounts for 0.25%, and the content of Schisandrin A accounts for 0.30%.

Embodiment 2

[0045] Prescription: 100g ginseng, 200g Ophiopogon japonicus, 100g schisandra, 120g hypromellose, hollow capsule, 65% ethanol solution

[0046] Preparation method:

[0047] The process route is as follows

[0048]

[0049] The ginseng, Ophiopogon and Schisandra are washed, crushed, soaked in a 65% ethanol solution for 24 hours and then subjected to wet treatment to obtain an extract. Put the hypromellose into the coating pan, spray the extract at a rate of 5-7ml / min at 40°C, and dry 500g of skeleton-shaped pellets. Put it into capsules to get 1000 capsules.

[0050] After testing, it contains ginsenoside Rg 1 The total content of Re accounted for 0.25%, the total content of Ophiopogon saponins B and D accounted for 0.35%, and the content of Schisandrin A accounted for 0.30%.

Embodiment 3

[0052] Using the process of preparing the matrix pellets in Example 1 or 2, different sustained-release materials such as methyl cellulose (MC), hypromellose (HPMC), povidone (PVP), ethyl cellulose, cellulose acetate , Polymethacrylate 80-100g, prepare 500g skeleton-shaped pellets, and then put them into capsules to obtain 1000 capsules. The test results are basically the same as those of Examples 1 and 2.

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Abstract

The invention is a pulse-activating sustained-release capsule and the preparing method thereof, belonging to the field of traditional Chinese medicine and preparing method, using gen-seng, Dwarf Lilyturf Tuber and Chinese Magnoliavine Fruit as raw medicinal materials, and obtaining extract by alcohol soaking and seeping processing; making the extract and sustained-release material into framework or coated pellets, and then putting the pellets in a hollow capsules so as to make a dispersive dosage sustained-release capsule. It can keep in-blood medicine concentration for long time; prolong curative effect and reduce toxicity and side effect, especially applied to patients suffering chronic diseases in need of long-time taking medicine, such as patients suffering from chronic lung-source heart disease.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicines and preparation methods thereof, and particularly relates to a slow-release Chinese patent medicine capsule for treating chronic cor pulmonale and a preparation method thereof. Background technique [0002] It is mentioned in the book "Medical Qiyuan": Shengmai San treatment is caused by warm heat, summer heat, exhaustion of qi and yin, or old cough, lung deficiency, and qi and yin injuries. Because summer heat is a yang evil, heat vaporizes a lot of sweat, it is most likely to consume qi and damage body fluids, causing both qi and yin injuries, so more sweating, mental fatigue, body fatigue, shortness of breath, dry throat, and weak pulse. The above signs can also be seen in people who have chronically injured the lungs when coughing and insufficient Qi and Yin. The method of replenishing qi, nourishing yin and promoting body fluid. In the prescription, ginseng is sweet and warm, nourishes...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/48A61P11/00A61P9/00
Inventor 滕利荣高波孟庆繁王贞佐王博
Owner JILIN UNIV
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