Trimetazidine hydrochloride bi-layer osmotic pump controlled release tablet and preparation method thereof

A technology for controlled release of trimetazidine hydrochloride and osmotic pump, which is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. problems, to maintain stability, prolong in vivo action time, and achieve good reproducibility
CN103735528AActive Publication Date: 2014-04-23SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2014-04-23

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Abstract

The invention provides a trimetazidine hydrochloride bi-layer osmotic pump controlled release tablet and a preparation method thereof. The osmotic pump controlled release tablet is formed by a drug-containing layer, a booster layer and a coating film, wherein the drug-containing layer comprises the following components in percentage by weight: 10-50% of trimetazidine hydrochloride, 30-80% of suspension agent and the balance of other auxiliary materials; the booster layer comprises the following components in percentage by weight: 20-90% of swelling agent, 5-70% of osmotic active substance and 0.5-5% of lubricating agent; the semipermeable coating film comprises 10-20g of semipermeable high polymer material and 1-5g of water-soluble pore-forming agent every 100 tablets. The trimetazidine hydrochloride bi-layer osmotic pump controlled release tablet can realizes constant release of drug in the body of a patient without being affected by pH value of a medium environment, enzyme, gastrointestinal motility and food, and is capable of maintaining the stability of plasma concentration of drug, reducing toxic and side effects of drug, decreasing dosing frequency and improving compliance of the patient.
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Description

technical field

[0001] The invention relates to a trimetazidine hydrochloride double-layer osmotic pump controlled-release tablet and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique

[0002] Trimetazidine hydrochloride has anti-epinephrine, norepinephrine and vasopressin effects, can reduce vascular resistance, increase coronary and circulating blood flow, promote myocardial metabolism and myocardial energy production, and reduce myocardial oxygen consumption, thereby Improve the supply and demand balance of myocardial oxygen. Compared with other antianginal drugs, it does not cause or cause minimal hemodynamic changes, and has obvious protective effect on ischemic myocardium, so it is also called myocardial nutritional protection drug.

[0003] In recent years, there have been many reports on oral preparations of trimetazidine hydrochloride, but most of them are ordinary tablets. Such as the common preparation of t...

Claims

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