Preparation method of novel melbine composition

A technology of metformin and metformin hydrochloride, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of patients forgetting to take, missing doses, and large fluctuations in blood drug concentration. Reduce side effects, reduce the number of times of taking medicine, and reduce the effect of toxic and side effects

Inactive Publication Date: 2020-03-17
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Metformin hydrochloride is a biguanide hypoglycemic drug that can improve insulin resistance and reduce the risk of major vascular complications (coronary heart disease, stroke), etc. Because of its small adverse reactions, it is widely used in the treatment of type Ⅱ diabetes and has become a biguanide However, at present, after patients take metformin hydrochloride ordinary tablets, the blood concentration fluctuates greatly, which may easily cause patients to forget to take or miss doses. Therefore, we propose a new preparation method of metformin hydrochloride composition to solve the problem above question

Method used

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  • Preparation method of novel melbine composition
  • Preparation method of novel melbine composition
  • Preparation method of novel melbine composition

Examples

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Effect test

Embodiment 1

[0022] A preparation method of a novel metformin composition, the preparation steps are as follows:

[0023] S1. First, the raw materials and auxiliary materials are screened and granulated using a screening machine with a 100-mesh screen;

[0024] S2. Then, take quantitative metformin hydrochloride 50mg, filler 10mg and 70% ethanol according to the prescription amount, and then fully mix it;

[0025] S3, after that, add an appropriate amount of 70% ethanol solution, and use a screening machine with 24 mesh screens to sieve and granulate;

[0026] S4. After the completion, place the prepared material in a blast drying oven at 55-60°C for drying, and then use a granulator with a 20-mesh screen for granulation;

[0027] S5. Finally, a certain amount of magnesium stearate is added, and after uniform mixing, tableting is performed to make a new metformin composition tablet.

Embodiment 2

[0029] A preparation method of a novel metformin composition, the preparation steps are as follows:

[0030] S1. First, the raw materials and auxiliary materials are screened and granulated using a screening machine with a 100-mesh screen;

[0031] S2. Then, take quantitative metformin hydrochloride 80mg, filler 20mg and 70% ethanol according to the prescription amount, and then fully mix it;

[0032] S3, after that, add an appropriate amount of 70% ethanol solution, and use a screening machine with 24 mesh screens to sieve and granulate;

[0033] S4. After the completion, place the prepared material in a blast drying oven at 55-60°C for drying, and then use a granulator with a 20-mesh screen for granulation;

[0034] S5. Finally, a certain amount of magnesium stearate is added, and after uniform mixing, tableting is performed to make a new metformin composition tablet.

Embodiment 3

[0036] A preparation method of a novel metformin composition, the preparation steps are as follows:

[0037] S1. First, the raw materials and auxiliary materials are screened and granulated using a screening machine with a 100-mesh screen;

[0038] S2. Then, take quantitative metformin hydrochloride 100mg, filler 30mg and 70% ethanol according to the prescription amount, and then fully mix it;

[0039] S3, after that, add an appropriate amount of 70% ethanol solution, and use a screening machine with 24 mesh screens to sieve and granulate;

[0040] S4. After the completion, place the prepared material in a blast drying oven at 55-60°C for drying, and then use a granulator with a 20-mesh screen for granulation;

[0041] S5. Finally, a certain amount of magnesium stearate is added, and after uniform mixing, tableting is performed to make a new metformin composition tablet.

[0042] Through the implementation of Examples 1-3, the best combination of each factor should be Exampl...

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Abstract

The invention discloses a preparation method of a novel melbine composition. The method comprises the following steps: S1, respectively screening and granulating raw materials and auxiliary materialsby using a screening machine with a 100-mesh screen; S2, weighing a certain amount of metformin HCL, filling agents and adhesives according to the prescription amount, and mixing the substances uniformly; and S3, adding a proper amount of 70% ethanol solution, carrying out screening and granulating by using a screening machine with a 24-mesh screen. According to the invention, the in-vitro drug release of the metformin HCL sustained release tablet is realized by a Hihuchi equation within 12 hours, which conforms to the drug release characteristics of common hydrogel sustained release preparations; since the main sustained release agent in the prescription is HPMC and the release of the water-soluble drug is mainly realized by diffusion of the drug from an HPMC skeleton to a dissolution medium, when the HPMC hydrogel is kept complete in the drug release process, the gel layer can play a role similar to a rate control diaphragm and thus the drug can be released at a relatively constant speed, so that the toxic and side effects of the drug are reduced, the daily drug taking frequency is reduced, and the compliance of a patient is improved.

Description

technical field [0001] The invention relates to the technical field of metformin hydrochloride, in particular to a preparation method of a novel metformin composition. Background technique [0002] Metformin hydrochloride is a sugar-coated or film-coated tablet, which is white after removing the coating. It is used for type II diabetic patients who are not satisfied with simple diet control, especially obesity and those with hyperinsulinemia. Metformin hydrochloride not only has hypoglycemic effect, but also It may have the effect of weight loss and hyperinsulinemia, and it can be effective for some patients with poor efficacy of sulfonylureas, such as combined with sulfonylureas, intestinal glycosidase inhibitors or thiazolidinedione hypoglycemic agents, The effect is better than that of single use, and it can also be used in patients treated with insulin to reduce the amount of insulin. [0003] Metformin hydrochloride is a biguanide hypoglycemic drug that can improve ins...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/155A61K47/38A61P3/10
CPCA61K9/2054A61K31/155A61P3/10
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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