18 results about "Spondylitis" patented technology

The utility model relates to the field of auxiliary devices, and discloses an ankylosing spondylitis auxiliary exercise device which comprises a seat plate, a long plate is hinged to the rear end of the seat plate, a waist protection massage assembly is arranged at the top end of the long plate, the waist protection massage assembly comprises a connecting plate, a sliding rail is arranged on the front surface of the connecting plate, and the sliding rail is connected with the long plate. A plurality of sets of supporting plates are slidably connected to the inner wall of the sliding rail, the multiple sets of supporting plates are symmetrically arranged with the center line of the connecting plate as the symmetry axis, a fixing plate is fixedly connected to the front surfaces of the supporting plates, a backup plate is fixedly connected to the top end of the connecting plate, and a neck protection block is slidably arranged on the front surface of the backup plate. According to the device, through cooperation of the waist protection pressing assembly, the neck protection block, the motor and the first electric push rod, the waist of a patient is massaged in the exercising process and during rest of the patient, the pressure of the waist is reduced, the pain of the waist after exercising is relieved, and the practicability of the device is improved.

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating ankylosing spondylitis, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5 to 10 parts of myrrh, 8 to 15 parts of rhizoma drynariae, 8 to 15 parts of fructus lycii, 8 to 15 parts of herba epimedii, 8 to 15 parts of radix achyranthis bidentatae, 2 to 6 parts of rhizoma galangae, 8 to 15 parts of fructus forsythiae and 10 to 15 parts of radix astragali seu hedysari. Animal experiments verify that the traditional Chinese medicine composition can remarkably inhibit inflammatory response and bone destruction by regulating T cell immune balance, has good pharmacological activity and safety for treating ankylosing spondylitis, and provides a scientific basis and an innovative application approach for research and development of new traditional Chinese medicines for treating ankylosing spondylitis.

According to the multi-label automatic diagnosis and evaluation system and method for ankylosing spondylitis, pelvic X-ray film images and clinical data are combined, automatic diagnosis of ankylosing spondylitis is achieved through a multi-label classification model, and the severity degree of injury of sacroiliac joints and hip joints is evaluated. The system adopts a prior attention mechanism, can automatically focus a key area in an image, and further improves the diagnosis efficiency. Experimental results show that the system still has relatively high diagnosis accuracy in an environment with limited resources, and can be comparable with diagnosis results of experienced doctors. The multi-label classification model with the priori attention mechanism provided by the invention provides a promising and cost-effective tool for diagnosis and evaluation of ankylosing spondylitis, and has important practical application value.

The invention provides a D-shaped hollow cylindrical thoracolumbar vertebra side wall interbody fusion cage for a rachitis operation, which belongs to the technical field of medical instruments for spine surgery, is an integrally formed rigid structure without movable parts, is a D-shaped hollow cylindrical body on the whole, and comprises a fusion cage cylindrical body with a fixed height, the cross section of a main body is D-shaped, and the cross section of the main body is L-shaped; the upper end face and the lower end face of an arc-shaped side wall and a plane side wall are enclosed by the upper end face and the lower end face; the cylindrical hollow cavity penetrates through the fusion cage cylindrical body in the axial direction, and the micron-sized rough textures are arranged on the outer surfaces of the arc-shaped side wall and the plane side wall. Anatomical matching with the lateral bone surface of the vertebral body is achieved through the D-shaped section, and load transmission and stress distribution are fundamentally improved in combination with large-area contact between the planar side wall and the end plate. Unprecedented initial stability is provided for the fusion cage in infectious loose bone, and the risks of displacement, sedimentation and disengagement are remarkably reduced.

The invention relates to application of an SOX5 inhibitor in preparation of a medicine for preventing and treating ankylosing spondylitis, and belongs to the technical field of biological medicine. The invention provides application of an SOX5 inhibitor in preparation of a medicine for preventing and treating ankylosing spondylitis. The SOX5 inhibitor inhibits SOX5 gene and / or protein expression. The SOX5 for inhibiting the starting and ending point stromal cells can accurately block the effect of mechanical stress on the ankylosing spondylitis starting and ending point disease, and meanwhile, interference on physiological mechanical stress signal transduction in normal tissues such as osteogenesis, cartilage and muscle is avoided. Through targeted inhibition of SOX5, formation of pathogenic cells (SDC1 + tendon sheath stromal cells) is reduced, transduction of mechanical signals to inflammation signals is blocked, and a more thorough and lasting treatment effect is achieved. By detecting the expression level of SOX5 in start-end point tissues, the kit is used for early diagnosis of AS start-end point diseases, assessment of disease activity and prediction of SOX5 targeted therapy response of patients.

The invention belongs to the technical field of biological detection, and discloses a marker combination for diagnosing ankylosing spondylitis and application thereof, and the key point of the technical scheme is that the marker combination is composed of TGF [beta] 3, BMP2, TNF [alpha] and sTNFR1. The invention also discloses application of the marker combination in preparation of a reagent for diagnosing ankylosing spondylitis. A detection sample of the reagent is serum, and the reagent is used for detecting the expression quantity and / or content of the marker combination. The marker combination provided by the invention has higher prediction value on an early pathological osteogenesis stage; the inflammation-dominated AS patient and the osteogenesis-dominated AS patient can be distinguished through combined detection; the detection system can be realized based on serum samples and is convenient to popularize and apply.

The invention discloses a biomarker for diagnosing ankylosing spondylitis. The biomarker is G6PD in a human peripheral blood mononuclear cell. The invention utilizes microarray analysis to detect differentially expressed mRNA in peripheral blood mononuclear cells, and confirms that these candidate mRNAs are indeed different and can be used as potential biomarkers for diagnosis of ankylosing spondylitis. The result shows that the expression change of the G6PD in the peripheral blood mononuclear cells of an ankylosing spondylitis patient can be used as a marker for diagnosing the ankylosing spondylitis, which is beneficial to exploring the pathogenesis of the disease, provides a new direction for the diagnosis of the ankylosing spondylitis and has a wide clinical application prospect.

A lower adjusting air cushion is fixedly installed at the top of a base, positioning grooves are formed in the surface of the lower adjusting air cushion at equal intervals, a neck pillow roller is installed at the top of one end of the lower adjusting air cushion, and back pillow rollers are installed in the middle of the lower adjusting air cushion at equal intervals. According to the spine kyphosis rehabilitation pillow, the expansion degree of the lower adjusting air cushion can be conveniently adjusted, then the degree of a concave arc formed by the back pillow roller and the neck pillow roller is adjusted, the spine kyphosis rehabilitation pillow is matched with different degrees of spine kyphosis of a patient, personalized support is provided, pain is relieved, and the sleep quality is improved; meanwhile, the inflation volume and the thickness of the upper adjusting air cushion are adjusted, the distance between the neck pillow roller and the back pillow roller and the back of the patient is changed, support with appropriate hardness is provided for the patient during nursing, the comfort of the patient is improved, the control mode is accurate, and operation is easier.

The invention relates to the technical field of antibacterial liquid, in particular to a composition formula and a preparation process of the antibacterial liquid. The traditional Chinese medicine is characterized by comprising the following components in percentage by mass: 5-30% of moutan bark, 5-30% of angelica sinensis, 5-30% of radix clematidis, 5-30% of rhizoma sparganii, 5-30% of almond, 5-30% of radix angelicae pubescentis, 5-30% of hippocampus, 5-30% of scorpion with clear water, 3-10% of pseudo-ginseng, 3-10% of ligusticum wallichii, 3-10% of hawthorn, 2-8% of tartary buckwheat, 2-8% of earthworm, 2-8% of frankincense, 2-8% of dragon's blood, 2-8% of astragalus membranaceus, 2-8% of pericarpium citri reticulatae, 2-8% of caulis bambusae in taeniam and 1-5% of mangacard. 1-5% of phryma leptostachya, 0.001-0.1% of nano-copper, and the balance of deionized water; according to the device, the channels and collaterals are quickly dredged at a fixed point, so that the blocked channels and collaterals are unobstructed, the pain is treated, the pain of ankylosing spondylitis, knee joints, soft tissues, lumbar vertebrae and cervical vertebrae can be relieved or solved, and the comfort of a patient is greatly improved.

The invention discloses an ankylosing spondylitis rehabilitation evaluation method based on posture recognition, and relates to the technical field of human body posture recognition, and the method comprises the steps: collecting and processing continuous video frames in the rehabilitation training process of a patient, and extracting spine key point information through a deep learning model; according to the method, the rehabilitation progress of a patient is calculated and evaluated by analyzing the activity range and posture deviation of each spine segment and combining preset rehabilitation target parameters and historical rehabilitation data. Through the combination of the time sequence characteristics and the spine structure offset matrix, the dynamic change of the spine can be accurately tracked, the weight is distributed for each spine segment, and segment activity range improvement and overall posture deviation improvement indexes are generated. And outputting a rehabilitation evaluation result according to a weighted result, and providing data support for a treatment scheme. Compared with a traditional assessment mode, the method can provide more accurate and dynamic rehabilitation effect assessment, and is suitable for assessment and adjustment of different patients and different rehabilitation stages.

This invention belongs to the field of traditional Chinese medicine. Specifically, it relates to a traditional Chinese medicine composition, preparation method, and application for treating ankylosing spondylitis. The raw materials include 10-20 parts of Achyranthes bidentata, 10-20 parts of Dipsacus asper, 5-15 parts of Astragalus complanatus, 5-15 parts of Curculigo orchioides, 10-15 parts of Spatholobus suberectus, 10-20 parts of Salvia miltiorrhiza, 5-10 parts of Liquidambar formosana, 5-10 parts of Clematis chinensis, 10-15 parts of Clematis armandii, 5-15 parts of Pinus massoniana, and 5-15 parts of Scrophularia ningpoensis. This formula is meticulously formulated, addressing both the root cause and the symptoms: it combines tonification and purgation, nourishing the liver and kidneys to treat the root cause, while also dispelling wind and cold, and promoting blood circulation to treat the symptoms. This formula can be used to treat ankylosing spondylitis with symptoms of liver and kidney deficiency, qi and blood stagnation, and cold-dampness obstruction, such as pain, stiffness, and limited mobility in the spine or sacroiliac joints, with significant stiffness upon waking and relief after activity, or accompanied by peripheral joint pain, aversion to cold, cold limbs, dark tongue or ecchymosis, and a deep, hesitant or wiry pulse.

The invention discloses a marker combination for pathological osteogenesis diagnosis of ankylosing spondylitis and application, and belongs to the technical field of diagnosis of ankylosing spondylitis. The biomarker combination used for pathological osteogenesis diagnosis of ankylosing spondylitis comprises CDR1, PLPPR2, CMBL, SRXN1 and PPP1R3C, and is characterized in that the biomarker combination is prepared from the CDR1, the PLPPR2, the CMBL, the SRXN1 and the PPP1R3C; the compound can be used for preparing products for evaluating the risk of spinal structure damage progress of patients with ankylosing spondylitis and screening pathological osteogenesis drugs for inhibiting and / or treating ankylosing spondylitis. The biomarker combination for diagnosing the pathological osteogenesis of the ankylosing spondylitis has high sensitivity and specificity when being used for diagnosing the pathological osteogenesis of the ankylosing spondylitis, and the diagnosis accuracy is greatly improved; the method can also be used for spinal structure injury progress risk assessment and screening of pathological osteogenesis drugs for inhibition and / or treatment of ankylosing spondylitis, and has a wide application prospect.

The present disclosure provides, in one aspect, specific doses of an ENPP1 agent for in vivo treatment of Diffuse idiopathic skeletal hyperostosis (DISH), Ankylosing Spondylitis, and / or Spondylarthritis.

The application discloses a detection device for ankylosing spondylitis in a rheumatology department, and relates to the technical field of medical devices.The technical scheme is as follows: a bottom plate is arranged, a side plate is arranged on the bottom plate, a sliding mechanism is arranged on the side plate, a sliding frame is arranged on the sliding mechanism, a binocular laser range finder is arranged on the sliding frame, a body protection mechanism is arranged on the bottom plate, a joint auxiliary mechanism is arranged on the bottom plate, which is used for assisting a patient to keep a knee joint in a straight state, a waist auxiliary mechanism is arranged on the bottom plate, which is used for guiding a patient to keep a waist close to the bottom plate in a stable state.The application standardizes a patient detection posture, eliminates subjective errors caused by posture differences in traditional manual measurement from the source, combines an intelligent detection system, realizes an overall process from posture automatic identification, voice guidance, laser accurate measurement to intelligent analysis, and greatly improves the accuracy of measurement data and detection efficiency.

This invention discloses a topical traditional Chinese medicine composition for treating pain and its preparation method. The composition includes Evodia rutaecarpa, Cinnamomum cassia, Carthamus tinctorius, Prunus persica, Smilax glabra, Saposhnikovia divaricata, Notopterygium incisum, Angelica pubescens, Boswellia carterii, Commiphora myrrha, Clematis armandii, Paris polyphylla, Ephedra sinica, Zingiber officinale, and Achyranthes bidentata. This invention has the effects of warming the meridians and promoting blood circulation, removing blood stasis, dispelling wind and dampness, reducing swelling and relieving pain. It is a safe, non-invasive, and low-cost external treatment method in traditional Chinese medicine, without burdening the liver and kidneys, and is simple to operate. It can effectively alleviate severe pain in patients with lumbar disc herniation, knee synovitis, rheumatoid arthritis, and late-stage ankylosing spondylitis. It also has rapid analgesic and functional recovery effects, improves symptoms such as insomnia and mobility impairment caused by pain, and improves the quality of life of patients.

The invention discloses application of a biomarker combination based on circular RNA and dNLR in preparation of a reagent combination or a kit for cross-HLA-B27 subtype diagnosis or auxiliary diagnosis of ankylosing spondylitis, belongs to the technical field of biomedical detection, and overcomes the defect that an existing marker is insufficient in sensitivity in early diagnosis of diseases. A new thought is provided for developing an AS non-invasive diagnosis strategy based on conventional detection parameters, and meanwhile a new direction is opened up for researching a synergistic effect mechanism of circRNA and conventional inflammation indexes.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a nanomaterial-mediated ankylosing spondylitis treatment preparation for specifically inhibiting MSC (mesenchymal stem cell) osteogenesis abnormality and application of the nanomaterial-mediated ankylosing spondylitis treatment preparation, and the technical scheme is characterized in that the preparation comprises a mannose-modified mesoporous silica nano-drug delivery system and Ikbkb siRNA (small interfering Ribonucleic Acid). The invention discloses a new mechanism that a tmTNF reverse signal drives pathological osteogenesis through a PSMA1-NF-kappa B axis under the stimulation of sTNFR I, and a mannose modified Man-MSN nano delivery system is constructed, so that active targeting on AS focus macrophages is realized; and by specifically knocking down Ikbkb, the key link of immune-osteogenesis transformation can be specifically blocked on the premise of not influencing the overall inflammation level.

The invention discloses a biomarker for evaluating the activity of ankylosing spondylitis. The biomarker is CYBB in human peripheral blood mononuclear cells. The invention utilizes microarray analysis to detect differentially expressed mRNAs in peripheral blood mononuclear cells, and confirms that these candidate mRNAs are indeed different and can be used as potential biomarkers for diagnosis of ankylosing spondylitis. The result shows that the expression quantity change of the CYBB in the peripheral blood mononuclear cells of the ankylosing spondylitis patient is positively correlated with the disease activity of the AS patient, and the CYBB plays a marker role in the diagnosis, activity evaluation and curative effect evaluation of the AS patient.