45 results about "Inflammatory lesion" patented technology

Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.

The present invention relates to a method of treating acne by topically applying a dermatological composition comprising dapsone. In addition to inflammatory lesions, the composition also treats non-inflammatory acne. The composition is formulated to include dapsone in a both a dissolved and microparticulate state.

Through experiments, the invention proves applications of a cape jasmine and a cape jasmine extract product in the preparation of drugs for treating myocardial infarction, coronary heart disease, myocardial ischemia and cardiac arrhythmia, especially to an application in treatment of acute myocardial ischemia or myocardial ischemia of coronary heart disease caused by restenosis after percutaneous transluminal coronary angioplasty (PTCA). In addition, it is proved through experiments that the above various kinds of applications are accomplished by protection of cardiac muscle and cardiac muscle cell from damage or resistance against inflammatory lesion and oxidative damage of cardiac muscle cell. And an effective dose of cape jasmine and the cape jasmine extract product in a unit preparation is obtained by detection.

Embodiments herein describe skincare compositions having colloidal silver, silver textiles coated with colloidal silver and acne treatment ingredient nanoparticles, methods of treating and preventing acne, rosacea, and other inflammatory lesions using such skincare compositions and textiles, methods of treating skin and preventing acne after resurfacing modalities using such skincare compositions and textiles, and kits for such methods. Embodiments also describe regimens for acne treatment and prevention using the described skincare compositions, textiles, and acne treatment compositions.

This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of micrometastasis and small proliferative lesions, in particular primary tumors, precancerosis, dysplasia, metaplasia, inflammatory lesions, e.g. psoriasis, psoriatic arthritis and / or rheumatoid arthritis, endometriotic lesions, and ocular diseases associated with angiogenesis.

The invention discloses a bacterial strain as well as a composition and application, and relates to the technical field of strain separation and application. The Cristinia sp. provided by the invention can be applied to treatment or prevention of liver function impairment and liver function impairment related diseases, alimentary canal mucosal injury and alimentary canal mucosal injury related diseases, diabetes, obesity and obesity related diseases. The inventor verifies that the Cristinia sp. provided by the invention has no toxic or side effect on the kidney and can reduce the weight of the liver; the initial steatohepatitis focus can be treated; fat accumulation of liver cells can be slowed down; AST and ALT in serum can be reduced; and abdominal white fat inflammatory lesion can be reduced. The Cristinia sp. can also repair the digestive tract mucosa, recover the barrier function of the mucosa, and prevent and treat intestinal leakage, peptic ulcer and other diseases caused by barrier function impairment. The Cristinia sp. also has the effects of reducing fasting blood-glucose of a body, regulating insulin level and reducing body fat of mammals, and has the effects of preventing and treating diabetes and improving the metabolic function of obese patients.

Chimeric antigen receptor (CAR)-expressing Tregs specifically target modified protein or proteins present in the extra cellular matrix of an inflammatory lesion of patients to induce a localized and effective immunosuppressive response.

The present invention relates to a method for treating, reducing or preventing acne. In particular, the present invention relates to methods for reducing the total number, incidence and severity of acne lesions on the skin which includes both inflammatory and non-inflammatory lesions. Further, the invention relates to reducing the incidence and severity of adverse events resulting from topical application of anti-acne agents resulting in improvement of skin tone. The method includes administering a novel and stable topical anti-acne pharmaceutical composition.

The invention discloses a visual anal fistula wall tissue scraping and cleaning device, which comprises a scraping rod, and is characterized in that one end of the scraping rod is provided with a scraping brush, the other end of the scraping rod is provided with a helical scraping rib, both the outer end part of the scraping brush and the outer end part of the scraping rib are provided with a cleaning guide block with a cavity, the outer end part of each cleaning guide block is respectively provided with a camera, the outer wall of each cleaning guide block is provided with a plurality of water spraying holes communicated with the corresponding cavity, the side wall of the middle part of the scraping rod is provided with a water inlet hole, the cavity of each cleaning guide block is communicated with the water inlet hole through a water inlet channel, there is a steering valve at the water inlet hole, and the steering valve enables the water inlet hole to be not simultaneously communicated with the cavities in the two cleaning guide blocks. The visual anal fistula wall tissue scraping and cleaning device has the advantages that the operation is convenient, the scraping rib and thescraping brush are enabled to rotate and lift at inflammatory lesion tissue parts of the anal fistula wall in a whole-process visual manner, and the anal fistula wall is sprayed with water and cleanedat the same time so as to effectively and thoroughly remove the inflammatory lesion tissues on the anal fistula wall.

The invention relates to a pharmaceutical antiseptic composition used to treat painful lesions of the oral mucous and ulcerative and inflammatory lesions of different origins. The invention also relates to the treatment and / or prevention of oral mucositis and stomatitis.

The invention provides an application of chemokine-like factor derived polypeptide for inhibiting inflammatory lesion, and particularly relates to an application in preparation of an anti-inflammatory drug. The polypeptide comprises 1) a polypeptide of an amino acid sequence shown in SEQ ID NO:1; or 2) a polypeptide which is obtained by deleting, inserting or placing one ore more amino acids in the polypeptide in 1) and is derived from the 1) and is as same as the polypeptide in biological function. The chemokine-like factor derived polypeptide can be used for preparing medicines for intervening or treating inflammatory lung injury diseases.

The invention relates to a topical pharmaceutical composition comprising effective amount of ivermectin as an active agent, process of preparation thereof and method of treating dermatological conditions such as inflammatory lesions of rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acne form rashes, and the like.

The present invention relates to the topical compositions comprising clindamycin phosphate, salicylic acid and tea tree oil; to the preparation methods thereof; and to the use thereof in the treatment of skin infections and acne vulgaris accompanied by inflammatory lesions.

The present invention relates to a method for treating, reducing or preventing acne. In particular, the present invention relates to methods for reducing the total number, incidence and severity of acne lesions on the skin which includes both inflammatory and non-inflammatory lesions. Further, the invention relates to reducing the incidence and severity of adverse events resulting from topical application of anti-acne agents resulting in improvement of skin tone. The method includes administering a novel and stable topical anti-acne pharmaceutical composition.

The invention relates to a medicine for treating partial lung qi deficiency type emphysema and in particular relates to a traditional Chinese medicine composition which is prepared by using Chinese herbal medicines as raw materials and is used for treating partial lung qi deficiency type emphysema. The traditional Chinese medicine composition is characterized by comprising the following active pharmaceutical ingredients by weight: 8-12g of red ginseng, 8-12g of barbary wolfberry fruit, 8-12g of Indian bread, 10-20g of astragalus mongholicus bunge and 1-2g of Chinese magnoliavine fruit. According to the dialectic theory of the traditional Chinese medicine, the traditional Chinese medicine composition has simple components, is accessible in materials and low in cost, has good curative effects, does not have any toxic or side effect, has the functions of freeing the lung and relieving asthma, reducing phlegm to relieve a cough, ventilating and activating blood, removing stasis and restoring elasticity, repairing airway inflammatory lesions and eliminating airflow obstruction and airway hyperreactivity to treat symptoms, and can be used for effectively treating partial lung qi deficiency type emphysema.

This combination of clindamycin (1%) and tretinoin (0.025%), solubilized in a hydrogel, resulted in significantly greater improvements in acne vulgaris (reduced lesion counts and ISGA) than either drug alone or vehicle and effectively treated both non-inflammatory and inflammatory lesions with a convenient, once-daily application.

The invention provides an application of chemokine-like factor derived polypeptides in inhibition of inflammatory lesions, and particularly relates to the application of the chemokine-like factor derived polypeptides in the preparation of anti-inflammatory drugs. The polypeptides comprise 1) polypeptides in an amino acid sequence as shown in SEQ ID NO:1; or 2) polypeptides derived by the 1) and provided with same biological functions with the polypeptides in the 1) by losing, inserting or replacing one or a plurality of amino acids in the polypeptides in the 1). The chemokine-like factor derived polypeptides can be particularly used for preparing interference or treating inflammatory lung injury diseases.

The invention discloses a method for treating adenoid hypertrophy and a preparation method of a special medicine bead ear point stick. The adenoid hypertrophy is also known as pharyngeal tonsillar hypertrophy, and mainly caused by infection or inflammatory lesions; in the past, western medicine operative treatment and adenoidectomy are often used in clinic of child patients, and the residual rateof adenoids is up to 94.9% in the method. The special medicine bead ear point stick is prepared from the components of10-15 g of trollflower, 10-15 g of kadsura root-bark, 5-10 g of rhizome pleionis,5-10 g of spica prunellae, 5-10 g of radix angelicae, 5-10 g of rhizome chuanxiong, 5-8g of pangolin scales, 3-5 g of flos magnolia, 3-5 g of liquoric root and 1-3 g of fructus xanthii. The method andthe preparation method are used for the treatment of adenoid hypertrophy and the preparation of the special medicine bead ear point stick.

The invention discloses a povidone iodine flushing disinfectant for women. The povidone iodine flushing disinfectant is prepared from an iodine solution, a mixed solution of glycerol and an aloe barbadensis solution and a traditional Chinese medicinal solution, wherein the iodine solution accounts for 95 percent, the mixed solution of the glycerol and the aloe barbadensis solution accounts for 4 percent, and the traditional Chinese medicinal solution accounts for 1 percent, counted by volume percent. The disinfectant disclosed by the invention is mainly used for flushing disinfection of vagina, urethra (mucosa) and vulva or can be used for flushing disinfection of trauma wound surface, animal scratch wound, bite wound, burns and scales, bedsore as well as inflammatory lesions of various bacteria and virus infection, or can be used for skin disinfection of daily injection, infusion and an operation field part. The disinfectant disclosed by the invention has the advantages of safety in use, no toxic or side effects, no allergy, no irritation to skin, mucosa, wound surface and vulvar tissues, good liquid medicine stability and two-year validity.

The invention relates to a medicine for treating interstitial emphysema and in particular relates to a traditional Chinese medicine composition which is prepared by using Chinese herbal medicines as raw materials and is used for treating interstitial emphysema. The traditional Chinese medicine composition is characterized by comprising the following active pharmaceutical ingredients by weight: 10-20g of Chinese angelica, 9-13g of fructus perillae, 7-11g of radix astragali, 7-11g of cassia twig, 10-20g of liquorice and 3-5g of cordyceps sinensis. According to the dialectic theory of the traditional Chinese medicine, the traditional Chinese medicine composition has simple components, is accessible in materials and low in cost, has good curative effects, does not have any toxic or side effect, has the functions of freeing the lung and relieving asthma, reducing phlegm to relieve a cough, ventilating and activating blood, removing stasis and restoring elasticity, repairing airway inflammatory lesions and eliminating airflow obstruction and airway hyperreactivity to treat symptoms, and can be used for effectively treating interstitial emphysema.

The invention discloses a traditional Chinese medicine formula for promoting blood circulation to remove blood stasis through skin permeation. The traditional Chinese medicine formula comprises 15 g of salvia chinensis, 10 g of frankincense, 10 g of myrrh, 15 g of spatholobus stem, 10 g of combined spicebush, 10 g of red sage root, 20 g of corydalis tuber, 6 g of gadfly, 30 g of ligustrum lucidum,polyacrylamide, C13-14 isoparaffin, laurinol polyether-7 (5%) and 4000 ml of purified water. The traditional Chinese medicine formula can improve blood circulation and promote pathological change recovery; an anticoagulation function is achieved, so that thrombus and arteriosclerosis plaques are prevented from being formed; the metabolic function of the body can be improved, and tissue repair andwound and fracture healing are promoted; the permeability of blood capillaries can be improved, inflammatory response is relieved, and fading and absorption of inflammatory lesions are promoted; themetabolism of connective tissues can be improved, the transformation and absorption of hyperplastic lesions are promoted, and the atrophic connective tissues are recovered.

The invention discloses an anal fistula wall tissue scraping and cleaning device, which comprises a scraping rod, and is characterized in that one end of the scraping rod is provided with a scraping brush, the other end of the scraping rod is provided with a helical scraping rib, both the outer end part of the scraping brush and the outer end part of the scraping rib are provided with a cleaning guide block with a cavity, the outer wall of each cleaning guide block is provided with a plurality of water spraying holes communicated with the corresponding cavity, the side wall of the middle partof the scraping rod is provided with a water inlet hole, the cavity in each cleaning guide block is communicated with the water inlet hole through a water inlet channel arranged in the scraping rod, there is a steering valve at the water inlet hole, and the steering valve enables the water inlet hole to be not simultaneously communicated with the cavities in the two cleaning guide blocks. The analfistula wall tissue scraping and cleaning device has the beneficial effects that the operation is convenient, the scraping rib and the scraping brush are enabled to rotate and lift at inflammatory lesion tissue parts of the anal fistula wall, and the anal fistula wall is sprayed with water and cleaned at the same time so as to effectively remove the inflammatory lesion tissues on the anal fistulawall.

The invention discloses an application of embelin to the preparation of a medicament for treating an autoimmune disease. As proved by an experimental result, the embelin can be used for suppressing the differentiation of human immune dendritic cells, the maturity of human immune dendritic cells activated by LPS (Lipopolysaccharide), the antigen uptaking capabilities of immature dendritic cells, the antigen presenting capabilities of mature dendritic cells, cell-T breeder reactions excited by dendritic cells, and the expression of cell factors which are secreted by dendritic cells and are usedfor promoting type 1 and type 17 cell differentiation of auxiliary cells T. Particularly, the embelin can be used for lowering the pathogenic degree of mouse experimental autoimmune encephalomyelitis. The invention relates to preparation of a medicament for suppressing an immune system, which can become a medicament for clinically treating autoimmune inflammatory lesions such as multiple sclerosis, acute disseminated encephalomyelitis and the like.

The invention discloses a Chinese herba preparation for treating chronic pancreatitis. According to traditional Chinese medicine, the chronic pancreatitis belongs to the category of stomachache, splenic precordial pain, diarrhea and the like. Damp-heat, Qi stagnation, blood stasis and phlegm accumulation are generated by the discord of the spleen and the liver and weakness of the spleen and the stomach, and as a result, durability inflammatory lesion occurs to pancreas. For this purpose, traditional Chinese medicine cynanchum thesioides, bitter bamboo leaves, cassia nomame, ginseng fruit, common hawksbeard, lespedeza cuneata G. Don, atractylodes, arundina graminifolia, haloragis micrantha, prunella vulgaris, black pepper and liquorice are selected, and decocted with water into decoction. Clinical tests show that the total effective rate reaches 97.5%, and the curative effect is remarkable.

The invention relates to a topical pharmaceutical composition comprising effective amount of ivermectin as an active agent, process of preparation thereof and method of treating dermatological conditions such as inflammatory lesions of rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acne form rashes, and the like.

The invention relates to a medicine for treating emphysema, particularly a traditional Chinese medicine composition for treating emphysema prepared from plant Chinese medicinal herbs. The invention is characterized in that the medicine is prepared from the following active pharmaceutical ingredients: 20-30g of semen ginkgo and 10-20g of honey. The medicine is on the basis of the traditional Chinese medicine authentication theory, and has the advantages of simple formula, accessible materials, low manufacturing cost, high curative effect and no toxic or side effect. The medicine has the effects of promoting the dispersing function of the lung, relieving asthma, clearing away phlegm, relieving cough, regulating vital energy, promoting blood circulation, reducing the stagnation, restoring elasticity, restoring bronchial inflammatory lesions and and eliminating air flow blockage and bronchial hyperresponsiveness so as to treat symptoms, and can effectively treat emphysema.

The invention relates to a hot compress formula for dredging the channel, relieving pain and promoting blood circulation to remove blood stasis, and a preparation method for the hot compress formula.The hot compress formula comprises the following raw material compositions: fructus liquidambaris, retinervus luffae fructus, herba lycopodii, herb of tuberculate speranskia, radix aconiti agrestis, rhizoma curcumae longae, rhizoma cyperi, folium artemisiae argyi, caulis piperis kadsurae, caulis trachelospermi, radix clematidis, lignum sappan, stigma croci, radix dipsaci, radix peucedani and flosrosae. The above raw materials are prepared according to a specific weight ratio and a specific preparation technology, the obtained hot compress formula can permeate into a diseased deep position through skin to perform the functions of dredging the channel, relieving pain, promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, dispelling wind and eliminating dampness and can effectively treat muscle, arthrosis, soft tissue pain and inflammatory lesions, including gonitis, scapulohumeral periarthritis, cervical spondylosis, protrusion of lumbar intervertebral disc and the like. By use of the invention, through a hot compress way of traditional Chinese medicines, heating power and medicine efficacy simultaneously penetrate into the channels and theorganism tissues of a patient from the body surface to take effects, so that the hot compress formula has the advantages of long medicine efficacy time, powerful medicine penetrability, no side effects and no complications, and therefore, patients are unlikely to relapse.

The present invention relates to a method for treating, reducing or preventing acne. In particular, the present invention relates to methods for reducing the total number, incidence and severity of acne lesions on the skin which includes both inflammatory and non-inflammatory lesions. Further, the invention relates to reducing the incidence and severity of adverse events resulting from topical application of anti-acne agents resulting in improvement of skin tone. The method includes administering a novel and stable topical anti-acne pharmaceutical composition.