The invention belongs to the technical field of uranium ore geological research, and particularly discloses a sandstone uranium ore comprehensive evaluation technology method. The method comprises thefollowing steps of 1, determining a uranium ore-forming favorable geological background and an ore-forming environment; 2, determining depositional subfacies or microfacies and spatial distribution of an ore-finding target layer; 3, identifying and locating a uranium ore-forming favorable sand body; 4, comprehensively extracting ore-forming favorable information; and 5, delineating an ore-formingfavorable region, and comprehensively evaluating ore-forming potential. According to the method, the steps are irreversibly carried out in sequence, and the uranium ore-forming potential of a regioncan be efficiently, quickly and objectively; uranium geological background and ore-forming environment analysis is a principal factor, wherein uranium source condition analysis is a top priority, andif the region does not have a uranium source condition, uranium ore does not exist no matter how good other conditions are; and by analyzing the ore-forming geological background and the ore-forming environment, favorable ore-forming geological conditions are determined.