119 results about "Sicca syndrome" patented technology

Methods of treating lupus, including systemic lupus erythematosus, cutaneous lupus erythmetosus, and lupus nephritis, are provided. The methods involve administration of a combination of a non-depleting CD4 antibody and another compound used clinically or experimentally to treat lupus. Methods of treating lupus nephritis by administration of a non-depleting CD4 antibody that results in an improvement in renal function and/or a reduction in proteinuria or active urinary sediment are also provided. Methods of treating multiple sclerosis by administration of a non-depleting CD4 antibody, optionally in combination with another compound used clinically or experimentally to treat MS, are described. Methods of treating transplant recipients and subjects with rheumatoid arthritis, asthma, psoriasis, Crohn's disease, ulcerative colitis, and Sjogren's syndrome are also provided.

This invention relates to one anti-extracting nuclear antigen spectrum array to ELISA test agent case for selecting for systematic lupus erythematosus, mixed connective tissue disease, Sjogren syndrome, systemic scleroderma, polymyositis and atrophic arthritis system self immune property antigen ENA spectrum micro array to enzyme immune agent case.

The invention discloses a health-care food or a traditional Chinese medicine preparation for preventing and/or treating dry syndrome and slowing down aging and a preparation method thereof. The health-care food or traditional Chinese medicine preparation is prepared by cooking by water and extracting from 5-60g of radix pseudostellariae, 5-60g of polygonatum, 10-80g of rhizoma anemarrhenae, 5-60g of white gourd kernel, 5-60g of ophiopogon root, 0.5-5g of ebony, 5-15g of almond, 10-80g of niger seed, 10-40g of gypsum, 1.5-10g of rhizoma coptidis, 3-10g of cinnamon, 5-20g of phellodendron, 10-40g of raw of Job's tears, 1.5-15g of liquorice, 10-40g of mulberry leaves, 10-30g of folium eriobotryae, 5-15g of colla corii asini, 5-100g of radix rehmanniae recen, 5-15g of fructus meliae toosendan, 10-50g of radix-polygoni multiflori and 5-40g of sealwort. The health-care food or traditional Chinese medicine preparation has the effect of supplementing qi, urishing yin, resisting virus, promoting fluid, moistening dryness, preventing and/or treating dry syndrome and slowing down aging, and is safe and effective.

The invention provides a Chinese medicinal composition for treating drying syndrome and a preparation method and application thereof. Mainly Chinese medicinal herbs comprising fragrant solomonseal rhizome, lily, grosvener siraitia, reed root, lalang root, dark plum fruit and licorice root are prepared into oral beverage, tablets, capsules or granules by adopting corresponding preparation methods.The Chinese medicinal composition has the functions of helping producing saliva and slaking thirst, and is used for treating the drying syndrome.

The invention discloses a medicinal composition for treating rheumatism. The medicinal composition is prepared from the following Chinese medicinal herbs serving as raw materials in parts by weight: 3-18 parts of wild ginger, 3-24 parts of dahurian angelica root, 3-18 parts of Chinese angelica, 6-36 parts of safflower, 3-18 parts of astragalus, 3-18 parts of barbary wolfberry fruit, 6-36 parts of honeysuckle flower, 3-18 parts of white paeony root, 3-18 parts of kudzuvine root, 2-8 parts of dried ginger and the like. The medicinal composition has good curative effects on various rheumatisms such as migratory arthralgia, arthritis, arthritis, obstinate arlhralgia and like, and has good curative effects on other similar relevant rheumatisms such as knee osteoarthritis, lumbar vertebra hyperosteogeny, knee osteoarthritis, gouty arthritis, ischemic necrosis of femoral head, women rheumatism (general aching during menstruation, pantalgia after childbirth and puerperal arthralgia), lupus sebaceous, psoriasis, sicca syndrome, and the like.

The invention discloses a Chinese medicine composition for curing sicca syndrome and a preparation method thereof. The Chinese medicine composition for curing the sicca syndrome mainly comprises the following components by weight: 1200-3000 parts of plaster stone, 200-450 parts of honeysuckle, 70-180 parts of the root barks of the peony trees, 70-180 parts of Indian iphigenia bulb, 200-450 parts of radix gentianae macrophyllae, 2000-450 parts of hedyotis diffusa, 200-450 parts of radix scrophulariae, 70-180 parts of radix puerariae, 200-450 parts of arisaema heterophyllum, 200-450 parts of coix Seeds, 200-450 parts of dried rehamnnia roots, 70-180 parts of radix paeoniae rubra, 200-450 parts of radix astragali and 200-450 parts of Japanese honeysuckle stems. The Chinese medicine composition for curing the sicca syndrome has the effects of nourishing yin, cooling blood, clearing heat, promoting diuresis, tonifying qi and dredging collaterals, and suitable for curing pain caused by dry eyes, dry mouths, dry skins, dry joints and the like.

The invention discloses a traditional Chinese medicine composition for treating sicca syndrome, and a preparation method and use thereof. The traditional Chinese medicine composition is prepared from22-35 parts by weight of radix scrophulariae, 20-30 parts by weight of radix ophiopogonis, 18-26 parts by weight of radix rehmanniae, 25-38 parts by weight of radix puerariae, 15-25 parts by weight ofrhizoma atractylodis and 12-18 parts by weight of root bark of the peony tree. The traditional Chinese medicine composition is remarkable in sicca syndrome treatment effect.

The invention discloses a secondary sicca syndrome epitope and an application thereof and belongs to the technical field of immunological diagnoses. The epitope is a polypeptide, and the amino acid sequence of the epitope is shown as SEQ ID NO: 1 in the sequence table. By means of an enzyme-linked immunosorbent assay (ELISA), reaction conditions of the epitope polypeptide and patient serums are detected; and according to the detection, the epitope polypeptide can be specifically combined with intravenous gamma globulin (IgG) in the patient serums instead of reacting with serums of healthy persons. The epitope polypeptide can be used for preparing drugs for diagnosing secondary sicca syndromes.

The invention relates to a Chinese medicine prescription for conditioning of diabetes and sicca syndrome. The components of the Chinese medicine prescription are prepared from the following Chinese medicines of, by weight, yam, mulberry, lily, polygonatum odoratum, fructus mume, raw hawthorn, kudzuvine roots and finger citron. According to the Chinese medicine prescription, through the scientific components, experimental research and number of years of clinical use, the therapeutic effect is verified. The Chinese medicine prescription has a very good therapeutic effect on diabetes and sicca syndrome, and the clinical symptoms of diabetes and sicca syndrome can be effectively improved.

The invention discloses a kit for detecting the relevant autoantibody spectrum of an autoimmune liver disease, and belongs to the technical field of biology. The kit comprises a membrane strip, an enzyme label liquid, a substrate and an enzyme label incubation buffer liquid, wherein the membrane strip is composed of a fixed plate as well as an antigen strip, a critical quality control strip and a functional quality control line which are sequentially fixed on a nitrocellulose membrane, wherein the antigen strip is formed by drawing 8 or 6 mutually independent drawing lines in AMA-M2, LKM-1, LC-1, SLA, F-action, gp210, Sp100 and La/SS-B on the nitrocellulose membrane. The kit can be used for detecting 8 relevant antibodies of the autoimmune liver disease, and can act as a basis for auxiliary diagnosis. The additionally arranged La/SS-B strip can be used for differentiating the autoimmune liver disease and liver injury caused by sicca syndrome, and thus providing a basis for the correct dosage regimen.

The invention provides a traditional Chinese medicine composition for treating sjogren syndrome. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of dogwood, 20 to 30 parts of rhizoma dioscoreae, 10 to 20 parts of rhizoma alismatis, 15 to 25 parts of rhizoma polygonati, 15 to 25 parts of fructus forsythiae, 10 to 20 parts of cistanche deserticola, 10 to 20 parts of radix paeoniae rubra, 10 to 20 parts of radix paeoniae alba, 10 to 20 parts of dendrobium nobile, 15 to 25 parts of cortex moutan, 15 to 25 parts of radix rehmanniae, 15 to 25 parts of poria cocos, 30 to 50 parts of radix ophiopogonis, 15 to 25 parts of eucommia ulmoides, 10 to 20 parts of cynanchum paniculatum, and 10 to 20 parts of liquorice. The traditional Chinese medicine composition has the effects of moistening lung and promoting secretion, so that the purpose of treating sjogren syndrome can be achieved. The invention also discloses a preparation method and application of the traditional Chinese medicine composition.

The invention relates to a traditional Chinese medicine composition for treating sicca syndrome, which is capable of effectively solving the problem of therapeutic medication for sicca syndrome. The traditional Chinese medicine composition is prepared from the 10-30 parts of American ginseng, 10-30 parts of white atractylodes rhizome, 5-20 parts of white hyacinth beans, 10-30 parts of white paeony root, 10-40 parts of liquorice, 10-30 parts of radix puerariae, 10-20 parts of lily, 5-10 parts of radix rehmanniae recen, 10-40 parts of glossy privet fruit, 10-40 parts of wolfberry, 10-40 parts of raw hawthorn, 5-20 parts of caulis spatholobi and 5-20 parts of sargentg loryvine. The traditional Chinese medicine composition disclosed by the invention is scientific and reasonable in formula, rich in raw materials, easy to produce and prepare, convenient to take and good in effect, has the effects of invigorating spleen and supplementing qi, nourishing heart and moistening lung, nourishing liver and kidney, and promoting blood circulation and removing stasis, and the effect of effectively improving the clinical symptoms, main immunological indexes and the like of patients with sicca syndrome, as well as is an innovation in medicines for treating sicca syndrome.

The invention provides a Chinese patent medicament for treating sjogren's syndrome and intractable oral ulcer and provides a preparation method thereof. The Chinese patent medicament preferably comprises the following Chinese medicinal components in part by weight: 7 parts of fresh hawthorn fruit, 6 parts of Mongolian snakegourd foot, 6 parts of scrophularia, 6 parts of asparagus, 6 parts of cape jasmine fruit, 6 parts of cortex lycii radicis, 6 parts of rehmanniae praeparatum, 2 parts of bletilla, 6 parts of honeysuckle flower, 7 parts of dwarf lilyturf tuber, 7 parts of white paeony root, 1.8 parts of largetrifoliolious bugbane rhizome and 7 parts of medicated leaven. The Chinese patent medicament for treating the sjogren's syndrome and the intractable oral ulcer has the advantages of good effect, obvious curative effect and relapse prevention after medicament discontinuance; patients do not need taking medicaments for a long time for maintaining; and the Chinese patent medicament has no medicament resistance, toxic or side effects.

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (COPD); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; Sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or Paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as Behçet's disease. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.

The invention relates to a colloidal gold testing card for testing sjogren's syndrome alpha-fodrin autoantibody. The testing card comprises orderly arranged components of, from left to right: a sample pad, glass fiber, a nitrocellulose membrane, and absorbent paper. Recombinant protein G labeled by nano-sized colloidal gold is applied on the glass fiber. Macromolecular-protein-coupled alpha-fodrin epitope polypeptide and recombinant protein G resistant antibody are fixed on the nitrocellulose membrane, wherein the sequence of alpha-fodrin epitope polypeptide is represented by SEQ ID NO: 1. Recombinant protein G resistant antibody fixed on the end close to the absorbent paper forms a control line, and macromolecule-protein-coupled alpha-fodrin epitope polypeptide fixed on the end close to the glass fiber forms a test line. The colloidal gold testing card provided by the present invention has advantages of easy preparation and quick testing. With the testing card, no professional technicist or expensive equipment is required. The testing card is suitable for large batch testing, and is suitable to be used in primary areas. The testing card has auxiliary diagnosis functions on early-stage sjogren's syndrome, and intermediate and advanced stage sjogren's syndromes.

Determination of anticholinergic M3 receptor and antibody is used to diagnose sicca syndrome. It has excellent sensitivity and specificity.

The invention provides a traditional Chinese medicine composition for health care and beautification, taking rhubarb and angelica as main components combined with Dangshen and Radix Hedysari to jointly perform the efficacy of promoting blood circulation by removing blood stasis, clearing away heat and toxic material, regulating the menstrual function, curing skin, beautifying and health care. Clinical and experimental data proves that the traditional Chinese medicine composition of the invention has favorable nursing and health care function for female irregular menstruation, hysteromyoma, cyst of uterus and dysmenorrhea, has specific nuring and health care function for the problems of female ovary and ovarian appendage, has favorable softening and eliminating function for female hyperplasia of mammary glands and lactocele, has favorable nursing function for various problems caused by constipation stagnation and has specific mitigation and treatment function for skin hutchinson-Gilford Syndrome, chloasma, recurrent chronic dermatitis of face, skin sicca syndrome, etc. Thus, the traditional Chinese medicine composition can be prepared into various preparations taken orally and external applied by conventional technology of traditional Chinese medicine pharmacy, and can be prepared into various skin care products according to the conventional technology used for producing skin care and beautifying products.

The invention discloses application of tofacitinib citrate and medicinal composition thereof in preparation of a medicament for treating sjogren's syndrome. The medicinal composition contains the tofacitinib citrate and/or optimal pharmaceutically-acceptable carriers or excipient. According to the medicinal composition, the sjogren's syndrome of mouths and eyes is obviously improved.

The invention provides a traditional Chinese medicine composition for preventing and / or treating sicca syndrome and a preparation method thereof. The composition consists of Codonopsis pilosula, radix polygonati officinalis, rhizoma anemarrhenae, Radix Ophiopogonis, cortex lycii radicis, liquorice and jujube, and the raw materials are prepared in honeyed pills for the treatment of sicca syndrome. The composition provided by the invention has reasonable formula, can improve body immunity and therapeutic effect, and does not cause relapse after drug withdrawal.

The invention relates to a polypeptide, a detector containing the polypeptide, and a detection kit containing the polypeptide. The polypeptide is composed of an amino acid sequence represented by the SEQ ID No.1. The polypeptide, the detector containing the polypeptide, and the detection kit containing the polypeptide are useful in the diagnosis of sicca syndrome.

The invention relates to a traditional Chinese medicament for treating sicca syndrome. The traditional Chinese medicament is prepared from the following medicinal materials in parts by weight: 14 parts of pnudicaule shell, 12 parts of tupistra chinensis baker, 12 parts of marchantia polymorpha lichen, 8 parts of Chinese tupistra rhizome, 12 parts of chloranthus officinalis blume, 14 parts of manyspike tanoak leaf, 8 parts of rodgersia aesculifolia, 8 parts of melastoma sanguineum sims, 15 parts of asarum macranthum, 10 parts of polystichum tsus-simense, 6 parts of euonymus sacrosancta koidz, 12 parts of fir club moss, 8 parts of cicerbita cyanea beauv, 10 parts of beonninghausenia sessilicarpa, 12 parts of calamus tetradactylus, 15 parts of aralia continentalis kitag and 14 parts of wild water-chestnut fruit. Clinical experiments prove that the traditional Chinese medicament can be used for safely and effectively treating sicca syndrome.

The invention discloses a composition for treating sicca syndromes and pattern/syndromes of yin deficiency and a preparation method and application of the composition. The composition comprises the following raw materials in parts by weight: 5-15 parts of lycium barbarum, 3-15 parts of chrysanthemum flos, 3-9 parts of cassia seeds, 6-15 parts of radix ophiopogonis, 6-20 parts of beautiful sweetgumfruits, 5-20 parts of white peony roots, 5-20 parts of dendrobe, 3-15 parts of smoked plums, 3-15 parts of hawthorns, 3-15 parts of turmeric and 2-10 parts of licorice roots. The composition is unique in formula, is composed of multiple traditional Chinese medicines for nourishing yin, generating body fluids and activating blood, has the functions of generating body fluids and moistening drynessas well as promoting blood circulation and removing meridian obstruction, is reasonable in dosage form and is convenient to take after being made into a tea preparation, and medicines can directly acton tongues, oral mucosae and parotid gland ends to alleviate symptoms, and have long-lasting actions after being absorbed; in addition, the composition disclosed by the invention is made of common traditional Chinese medicines and is low in price, so that patients have low economic burden, and good social benefits and economic benefits can be achieved.