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A traditional Chinese medicine composition for treating Sjögren's syndrome, its preparation method and application

A technology for Sjögren's syndrome and composition, which is applied in the field of traditional Chinese medicine composition and preparation for treating Sjögren's syndrome, and can solve the problems of no special treatment method for Sjögren's syndrome, ineffective immunosuppressant effect, and damage to other organs due to drug resistance. To achieve the effect of non-toxic side effects, strict compatibility and reasonable design

Active Publication Date: 2011-12-07
南通金羽禽业发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the disease is an autoimmune disease, the curative effect of immunosuppressants on this disease is not obvious
Existing therapeutic drugs can be divided into four categories: ① surface replacement (artificial tears); ② choline receptor agonists (pilocarpine nitrate injection); ③ anti-surface inflammation drugs (cyclosporine eye drops) ; ④ Immunomodulatory drugs (methotrexate, cyclophosphamide, etc.), no special treatment for Sjogren's syndrome
[0007] The above various medicines can only alleviate the superficial symptoms, the curative effect is not ideal, and it is easy to relapse after stopping the medicine. The patient has to take medicine for a long time to maintain, and then it is easy to produce drug resistance and damage other organs. disease, has become the eager expectation of the majority of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Take 6g of Polygonatum Polygonatum, 8g of Lily, 6g of Luo Han Guo, 14g of Reed Rhizome, 6g of Imperatae Rhizome, 10g of Black Prune, and 4g of Licorice and combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, and decoct Boil for 1.5 hours, add water for the second time to be 8 times the weight of the medicinal material, decoct for 1.5 hours, combine the decoction, concentrate under reduced pressure at 0.07MPa and 65°C to an extract with a relative density of 1.15 at 65°C, add 95% ( v / v) ethanol to make the alcohol content reach 75% (v / v), stir, stand still for 24 hours, filter, and the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and Recover ethanol to obtain a concentrated solution, spray dry (the conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 80°C, the atomiz...

Embodiment 2

[0038] Example 2: Take 8g Polygonatum Polygonatum, 6g Lily, 8g Luo Han Guo, 12g Reed Rhizome, 8g Imperata Rhizome, 8g Black Plum, and 6g Radix Glycyrrhizae, add water to decoct twice, add water for the first time to 8 times the weight of the medicinal materials, and decoct Boil for 1 hour, add water 6 times the weight of the medicinal materials for the second time, cook for 1 hour, combine the decoction, concentrate under reduced pressure at 0.07MPa at 65°C to extract with a relative density of 1.20 at 65°C, add 95% (v / v) Ethanol to make the alcohol content reach 65% (v / v), stir, stand still for 24 hours, filter, and concentrate the filtrate under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and recover ethanol , to obtain a concentrated solution, filter, add appropriate amount of water and sucrose to prepare an oral drink.

Embodiment 3

[0039] Example 3: Take 10g Polygonatum Polygonatum, 4g Lily, 10g Luo Han Guo, 10g Reed Rhizome, 10g Imperata Rhizome, 6g Black Plum, and 8g Radix Glycyrrhizae, add water to decoct twice, add water for the first time to 12 times the weight of the medicinal materials, and decoct Boil for 2 hours, add water 10 times the weight of the medicinal materials for the second time, cook for 2 hours, combine the decoction, concentrate under reduced pressure at 0.07MPa, 65°C to the extract with a relative density of 1.20 at 65°C, add 95% (v / v) Ethanol to make the alcohol content reach 85% (v / v), stir, stand still for 24 hours, filter, and the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.30 at 65°C, and ethanol is recovered , to obtain a concentrated solution, spray-dried (conditions are that the inlet air temperature is 120°C, the outlet air temperature is 100°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the...

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PUM

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Abstract

The invention provides a Chinese medicinal composition for treating drying syndrome and a preparation method and application thereof. Mainly Chinese medicinal herbs comprising fragrant solomonseal rhizome, lily, grosvener siraitia, reed root, lalang root, dark plum fruit and licorice root are prepared into oral beverage, tablets, capsules or granules by adopting corresponding preparation methods.The Chinese medicinal composition has the functions of helping producing saliva and slaking thirst, and is used for treating the drying syndrome.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating Sjögren's syndrome, a preparation method and application. Background technique [0002] Sjögren's syndrome is a chronic autoimmune disease mainly invading lacrimal glands, salivary glands and other exocrine glands, also known as autoimmune exocrine gland disease. The main manifestations are sicca cornea, conjunctivitis, xerostomia or other rheumatic diseases associated with rheumatoid arthritis, which can involve other systems such as respiratory system, digestive system, urinary system, blood system, nervous system and muscle, Joints, etc. cause multi-system and multi-organ damage. [0003] The incidence of primary disease is high, mostly in women over 40 years old. The pathological mechanism is mainly due to the excessive autoimmune response, resulting in the infiltration of a large number of lymphoc...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P37/02A61P29/00
Inventor 不公告发明人
Owner 南通金羽禽业发展有限公司
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