101 results about "Diphenhydramine hydrochloride" patented technology

An allergy emergency kit (AEK) for use in treating urgent allergic reactions in common areas for allergens to exist. Generally speaking, the kit comprises a container for securing allergy medicines, a customizable panel for fastening allergy medicine in an orderly fashion, at least anaphylaxis device fastened to the panel and positioned within the container, and an instruction sheet positioned within the container and listing urgent care details for victims of allergens. Preferably, the anaphylaxis device includes at least one of either an adult-dosed and a child-dosed anaphylaxis device such as an EpiPen or similar epinephrine injection device. The allergy emergency kit may also contain auxiliary allergy medicine, such as diphenhydramine hydrochloride, antihistamine, anti-inflammatory, anti-itch, pain relief, mild sedative, asthma inhaler, ipecac, anti-nausea medicines and other such medicines, herbs or remedies which might be useful in treating the symptoms of an allergic reaction.

The invention relates to the medicine field and specifically discloses an arthralgia relieving gel. The arthralgia relieving gel is prepared from raw materials including the following components in parts by weight: 160-240 parts of capsicum fluid extract, 90-140 parts of atropa belladonna fluid extract, 30-50 parts of dementholized peppermint oil, 70-90 parts of methyl salicylate, 160-240 parts of camphor, 10-15 parts of diphenhydramine hydrochloride, 1-10 parts of triethanolamine, 2-30 parts of carbomer, 1-3 parts of ethylparaben, 3-40 parts of hydroxypropyl methylcellulose, 50-100 parts of glycerin, 1-10 parts of ethanol, 1-5 parts of azone and a proper quantity of water; all the raw material components are of 1000 parts in total. The invention also discloses a preparation method of the arthralgia relieving gel. Compared with the existing arthralgia relieving plaster in the prior art, the arthralgia relieving gel has the advantages of good stability, easy absorption, remarkable medical effect, low skin irritation and safe production.

The present invention discloses a Chinese medicine with the functions of promoting blood circulation, stopping pain, removing blood stasis, promoting the growth of new tissues and eliminating arthralgia and myalgia and preparation process of its adhesive plaster. It is made up by using 8 Chinese medicinal materials of notoginseng, dahurian angelica root, winglass cockroach, ligusticum root, Chinese angelica root, carthamus flower, borneol and camphor as main raw material and adding methyl salicylate, mentha camphor, belladonna liquid extract, chondroitin sulfate, diphenhydramine hydrochloride and dimethyl sulfoxide as auxiliary material through a certain preparation provess.

The invention discloses a preparation process of traditional Chinese medicine rubber electuary medicine and paste. The method comprises the following steps: (1) cutting rubber; (2) refining rubber; (3) soaking rubber; (4) thermally mixing; (5) adding materials for the first time; (6) adding materials for the second time; (7) adding traditional Chinese medicines; (8) filtering and discharging; the traditional Chinese medicine rubber electuary medicine can be traditional Chinese medicine extract prepared from illicium verum, rhizoma kaempferiae, unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, herba ephedrae, as well as artificial moschus, borneol, menthol, camphor, methyl salicylate, chondroitin sulfate and diphenhydramine hydrochloride, or can be dampness damage and pain relieving liquid extract, mastic resinoid, belladonna liquid extract, artificial moschus, borneol, menthol, camphor and methyl salicylate. According to the preparation method, the whole substrate is fully emulsified and fused; when in coating, the paste is dispersed through the tension force on the surface, and therefore, the paste can be easily combined with a medical cloth; the paste is proper in viscosity, does not lead to rubber falling, is beneficial for transdermal absorption of medicines, and has lasting effect.

A composition for local anesthesia which comprises a local anesthetic such as lidocaine hydrochloride as an active ingredient and an agent for sustaining anesthetic action selected from the group consisting of antihistamines such as diphenhydramine hydrochloride or hydroxyzine hydrochloride, and does not substantially contain catecholamines such as epinephrine, which has increased durability of anesthetic action without using catecholamines, and is useful as a safe composition for local anesthesia for performing short-time dental operations such as tooth extraction or oral surgery operations.

The invention discloses ointment for treating neck, shoulder, low-back and leg pain. The ointment for treating neck, shoulder, low-back and leg pain is prepared from rhizoma et radix notopterygii, radix angelicae pubescentis, caulis spatholobi, rhizoma ligustici, radix paeoniae rubra, radix clematidis, radix angelicae sinensis, radix puerariae, rhizoma atractylodis, radix saposhnikoviae, radix achyranthis bidentatae, radix stephaniae tetrandrae, radix gentianae macrophyllae, rhizoma drynariae, rhizoma cibotii, rhizoma dioscoreae collettii, radix astragali, unprocessed radix polygoni multiflori, radix dipsaci, carapax et plastrum testudinis, semen persicae, fructus chaenomelis, herba lycopodii, herba speranskiae tuberculatae, flos carthami, cortex eucommiae, cortex acanthopanacis, ramulus cinnamomi, folium perillae, radix aconiti, radix aconiti kusnezoffii, semen strychni, frankincense, myrrh, centipedes, scorpion, zaocys, lumbricus, sanguis draconis, radix aucklandiae, semen brassicae, rhizoma corydalis, resina ferulae, herba asari, cortex cinnamomi, radix notoginseng, dried condensed decoction peeled branches and trunks of acacia catechu, menthol, borneolum syntheticum, camphor, semen ricini, fruits of fragrant citrus, fructus liquidambaris, diphenhydramine hydrochloride tablets, far infrared ceramic powder and the like. The invention further discloses a preparation method of the ointment for treating the neck, shoulder, low-back and leg pain. The ointment for treating the neck, shoulder, low-back and leg pain and the preparation method of the ointment for treating the neck, shoulder, low-back and leg pain have the advantages that cost is low, preparation is easy, side effects are avoided, curative effect is remarkable and the like.

The invention discloses an electrochemical-luminescence sensor for quickly detecting diphenhydramine hydrochloride by high sensitivity and a preparation method thereof. The preparation method comprises the following steps: connecting and synthesizing carbon nano tubes and nano gold into a WMCNT-CYs-AuNPs nano composite material by cysteine, modifying a WMCNT-CYs-AuNPs / Nafion nano composite membrane on the surface of a glassy-carbon electrode, then utilizing the nano composite membrane to immobilize a luminescence reagent terpyridyl ruthenium (Ru(bpy)32+), constructing the electrochemical-luminescence sensor based on Ru(bpy)32+ / WMCNT-CYs-AuNPs / Nafion. The synthesis method is simpler and does not need expensive instruments; the sensor constructed by the invention has the characteristics of high sensitivity, low detection limit, wide linear range, and good stability and reproducibility and the like. The electrochemical-luminescence sensor is reasonable in recovery rate and obtains a better result for detecting market diphenhydramine injection.

The invention discloses a composition for treating dermatitis and symptoms caused by mosquito bites and a preparation method thereof. The composition comprises: by mass, 20 to 30 parts of diphenhydramine hydrochloride, 10 to 20 parts of camphor, 60 to 70 parts of peppermint oil and 2 to 3 parts of glycyrrhetinic acid. The preparation method comprises the following steps of 1, crushing and uniformly mixing the raw materials according to the mass ratio to obtain a mixture, and 2, dissolving the mixture as a solute obtained by the step 1 in an ethanol solution having an ethanol concentration of 60 to 65% by stirring to obtain a mixed solution having a mass ratio of 8.2 to 10%, wherein the mixed solution is the composition. The composition can prevent mosquito bites and treat dermatitis caused by mosquito bites. A large amount of experiments prove that the composition has good effects of repelling mosquitos and treating symptoms such as pain and itch, skin redness and swelling, and dermatitis caused by mosquito bites, and is safe and convenient in use.

The invention discloses a method for controlling quality of red medicinal gel. In the method, the contents of pseudo-ginseng and diphenhydramine hydrochloride in the red medicinal gel are detected by adopting a high performance liquid chromatography method, and effective substances are identified. Requirement to the method is improved based on National Formulary and national standard, and the method represents the advantages of simple operation, detection conservation, reagent toxicity reduction, specificity improvement and the like.

The invention provides a method for measuring the content of diphenhydramine hydrochloride. Compared with the traditional method, the method has the advantages of simpleness in experimental apparatus, low testing cost, convenience, rapidness, more accuracy in measuring results, wider linear range and higher sensitivity, and is a simplest and most feasible method for measuring the content of the diphenhydramine hydrochloride.

The present invention discloses a Guanxin adhesive plaster and its production process. It is made up by using the Chinese medicinal materials of salvia root, ligusticum root, Chinese angelica root, carthamus flower, myrrh, clove, frankincense, dalbergia wood, camphor, xylene musk, menthanol, diphenhydramine hydrochloride, borneol and medical carrier rubber plaster matrix through a certain preparation process. Besides, said invention also provides the concrete steps of said preparation process.

The present invention relates to one kind of chronic trachitis treating Chinese medicine and its preparation. The Chinese medicine is prepared with atractylodes rhizome and orange peel for eliminating wetness evil; glossy ganoderma for invigorating lung and kidney to relieve cough and asthma; mankshood for warming Yang to eliminate phlegm; ephedra for warming lung to eliminate phlegm and relievecough and asthma; dahurian rhododendron leaf for eliminating phlegm and relieving cough; forsythia and climbing groundsel herb for clearing away heat and toxic matter and diphenhydramine hydrochloride for relaxing bronchus smooth muscle. With the functions of warming kidney, invigorating Yang, eliminating wetness evil, etc., the present invention can cure chronic trachitis radically.

The invention belongs to the technical field of plaster preparations and particularly relates to an external use plaster used for easing pain and strengthening the bone. The external use plaster is prepared from a rhizoma kaempferiae fluid extract, musk, menthol, methyl salicylate, a leopard bone, chondroitin sulfate, borneol, diphenhydramine hydrochloride, camphor, zinc oxide, rosin, wool fat, vaseline, a transdermal enhancer, a tackifier, an increasing milk agent, and a rubber; the transdermal enhancer comprises a monarch drug and an adjuvant, wherein the monarch drug is combination of N-dimethylamino n-butyrate dodecyl ester and one of alpha-bisabolol, ferulic acid and glycerinum monopentyl ether, and the adjuvant is methyl trioctyl ammonium chloride or bromo-1-butyl-3-methyl-imidazole. The external use plaster has a very obvious effect of easing pain and strengthening the bone, has excellent transdermal absorptivity at the same time and takes effects quickly, the effective ingredients in the plaster do not volatilize easily, the viscidity of the plaster is good, and the quality is even. Meanwhile, the ingredients of the plaster are much easier to absorb by the skin after an emulsified slurry is made and gelatinized.

The invention discloses a western medicine ointment for eliminating abscess. The ointment is prepared from, by weight, 5-15 parts of erythromycin; 20-30 parts of ciprofloxacin; 10-20 parts of mupirocin; 8-15 parts of polyethylene glycol; 8-15 parts of benzalkonium chloride; 5-10 parts of triethanolamine; 10-15 parts of glycerin; 5-10 parts of laurocapram; 0.1-0.5 part of ethylparaben, 1-3 parts ofsodium lauryl sulfate, 5-15 parts of benzalkonium chloride; 5-10 parts of methyl salicylate; 2-10 parts of diphenhydramine hydrochloride; 5-15 parts of procaine hydrochloride; 100-150 parts of water.The ointment is simple in formula and has effects of promoting ulcer wound healing and eliminating abscess. The ointment has the advantages of exquisite appearance, easy application, moderate consistence, heat resistance, cold resistance, rapid effect and short treatment period and meets the current use requirements.

The invention relates to the field of traditional Chinese medicines, and provides a Chinese and western medicine external patch for treating scapulohumeral periarthritis. An emplastrum is prepared from the following active ingredients and auxiliary materials in parts by weight; the active ingredients comprise 0.1 to 0.3 part of moschus, 100 to 200 parts of radix notoginseng, 50 to 100 parts of safflower, 50 to 100 parts of radix salviae miltiorrhizae, 1.2 to 1.8 parts of boric acid, 1.2 to 1.8 parts of root of cinnamomum camphora, 3 to 6 parts of dragon's blood, 1 to 5 parts of urea, 10 to 20 parts of extractum belladonnae liquidum, 0.5 to 1.5 parts of diphenhydramine hydrochloride, and 1 to 3 parts of procaine hydrochloride; the auxiliary materials comprise 280 to 350 parts of rubber, 120 to 160 parts of rosin, 350 to 450 parts of zinc oxide, 30 to 50 parts of lanolin, and 10 to 20 parts of vaseline. The emplastrum has the advantages that the effects of activating blood circulation and dredging collaterals, and sterilizing bacteria and relieving pain are realized, the emplastrum quickly takes effect, the curative effect is obvious, any side effect is avoided, the safety is high, the convenience in use is realized, and the like; the effect of treating the scapulohumeral periarthritis is obvious, and the curative rate is 92%.

The invention discloses an external medicine for treating skin diseases. The medicine is characterized by at least comprising diphenhydramine hydrochloride, epinephrine hydrochloride and lidocaine hydrochloride in a weight ratio of (1.25-10):(0.025-0.5):(2.5-25). The medicine is a non-hormone external medicine which can be used for effectively treating acute and chronic allergic and congestive skin diseases, autoimmune skin diseases and the like.

The invention provides an ibuprofen diphenhydramine dispersing tablet, which consists of the following components in percentage by mass: 40 percent of ibuprofen, 5 percent of diphenhydramine hydrochloride or 7.6 percent of diphenhydramine citrate, 30-43 percent of a filler, 5-15 percent of a disintegrant, 2-8 percent of a bonding agent, 0.1-1 percent of a surfactant, 1.5-4 percent of a lubricating agent and 0.5-1.5 percent of a flavoring agent, wherein the filler is at least two of microcrystalline cellulose, pre-gelatinized starch, lactose and mannite; the disintegrant is cross-linked sodiumcarboxymethylcellulose and / or cross-linked polyvidone; the bonding agent is polyvidone K30; the surfactant is sodium dodecyl sulfate; the lubricating agent is magnesium stearate and superfine silica gel powder; and the flavoring agent is aspartame and steviosin. The invention further provides a preparation method of the dispersing tablet. The preparation method is easy and convenient to operate, has low cost, and is suitable for industrial production. An obtained product has stable and controllable quality, attractive appearance, good mouthfeel and proper hardness, is fully disintegrated in water at the temperature of 20+ / -1 DEG C within 3 minutes, and passes through a No.2 sieve; and the medicament dissolvability is over 85 percent 30 minutes later.

The invention relates to a Hongyao Babu plaster used for treating injuries from falls, fractures, contusions and strains, promoting blood circulation to arrest pain, removing blood stasis to promote generation of new blood and relieving sore pain of muscles and bones and a preparation method of the Hongyao Babu plaster, and belongs to the technical field of traditional Chinese medicines. The Hongyao Babu plaster is prepared from the following raw materials: pseudo-ginseng, radix angelicae, ground beeltle, ligusticum wallichii, angelica sinensis, carthamus tinctorius, borneol, camphor, methyl salicylate, menthol, a belladonna liquid extract, chondroitin sulfate, diphenhydramine hydrochloride, dimethyl sulfoxide, purified water, gelatin, sodium polyacrylate, glycerin, sorbitol, kaolin, liquid paraffin, polysorbate 60, citric acid and sodium carboxymethylcellulose. The Hongyao Babu plaster has no irritative and allergic reaction to skin, so that the plaster is high in safety; the plaster has a good water-retaining property, so that the stratum corneum of the skin is easily softened, and the transdermal absorption of medicines is facilitated; and the breathability, the skin tackiness and the heat retaining property of the Hongyao Babu plaster are superior to those of the traditional Hongyao plaster. The Hongyao Babu plaster provided by the invention is rapid in therapy, short in treatment course and good in analgesic effect. Thus, the Hongyao Babu plaster provided by the invention is obviously superior to the traditional Hongyao plaster.

The invention discloses a slow-release type solid corrosion inhibitor and a preparation method thereof. The solid corrosion inhibitor is prepared from the following materials: 60 percent to 70 percent of a main material and 30 percent to 40 percent of an auxiliary material; the main material is formed by compounding three components of amantadine hydrochloride, diphenhydramine hydrochloride and dextromethorphan hydrobromide according to a molar mass ratio of 2 to 2 to 1; the auxiliary material is formed by compounding carnauba wax, pregelatinized starches, polyvinylpyrrolidone, microcrystalline cellulose, carboxymethyl starch sodium and stearic acid according to a mass ratio of 3 to 3 to 2 to 2 to 2 to 1. The preparation method comprises the following steps: after mixing the auxiliary material evenly according to a formula ratio, stirring and heating to 80 DEG C to 90 DEG C, melting the auxiliary material, slowly adding the main material, which is mixed evenly according to a formula ratio, into the molten auxiliary material, continuously stirring and heating, after sufficiently mixing the main material and the auxiliary material evenly, putting into a mould for compression molding, and cooling to obtain a finished product of the solid corrosion inhibitor. The corrosion inhibitor is low in usage amount, long in release period, good in corrosion inhibiting effect, simple in preparation and putting process, and suitable for anticorrosion for an oil well and an underground tube and rod.

The present invention relates to a pain treatment plaster and a preparation method thereof. The pain treatment plaster treat can treat cancer pain, improve quality of life of cancer patients, prolong the survival time, can also treat pains caused by external rheumatalgia, various injuries from falls, fractures, contusions and strains, soft tissue injuries and the like. The pain treatment plaster comprises the following original drugs by weight: 2.5-10 parts of venenum bufonis, 75-150 parts of radix aconiti kusenzoffii, 100-200 parts of radix zanthoxyli, 50-100 parts of paris polyphylla, 50-100 parts of raw Korean mondshood root, 50-100 parts of hibiscus leaves, 50-100 parts of rhizoma sparganii, 50-100 parts of curcuma zedoary, 50-100 parts of safflower, 25-50 parts of cloves, 25-50 parts of asarum, 25-50 parts of cinnamon, 25-50 parts of dysosma versipellis, 25-50 parts of fructus piperis longi, 50-100 parts of rhizoma nardostachyos, 25-50 parts of rhizoma kaempferiae, 50-100 parts of frankincense, 50-100 parts of myrrh, 100-200 parts of menthol, 50-100 parts of borneol, 50-100 parts of camphor, 25-50 parts of methyl salicylate, 25-50 parts of benzyl alcohol, 50 parts of diphenhydramine hydrochloride and 200 parts of azone.

The invention relates to the technical field of medicine, which is characterized in that more than 600 types of small molecular drugs authorized by FDA are used for high throughput screening, wherein, diphenhydramine hydrochloride has the most obvious inhibition effect on CD4+T cells. According to the invention, an experimental auto-immune encephalomyelitis model (the EAE model) is constructed, the EAE model is used for researching the damage effect on inner inflammatory demyelinating diseases by diphenhydramine hydrochloride, and the experiment finds that diphenhydramine hydrochloride has effect for adjusting TH17 cell differentiation and inflammatory demyelinating damage. The invention provides the application of diphenhydramine hydrochloride in preparation of medicine for treating experimental auto-immune encephalomyelitis, and an application for preparing the medicines for preventing or treating multiple sclerosis.

The invention discloses a method for preparing ointment for treating lumbar disc herniation, and belongs to the field of preparation methods of medicinal ointments. The ointment consists of clematis root, corydalis tuber and the like. The method comprises the following steps of: preparing beta-cyclodextrin covered volatile oil by adopting a grinding method; extracting clematis root, fructus gleditsiae and the like and residue of asarum and illicium verum for three times and 2 hours every time by adding 6 times of 60 percent ethanol, combining filtrate, and concentrating to obtain extract of which the relative density is 1.10 to 1.20; stirring borneol, diphenhydramine hydrochloride and the like, dissolving, mixing with zinc oxide, crushed rosin, rubber and the like uniformly, and standing for 15 to 20 hours in a rubber soaking basin; and extracting and concentrating the medicinal materials into the extract, mixing the extract, the beta-cyclodextrin covered volatile oil, the rubber and other matrix, thermally pressing to prepare paste, coating, bushing, slicing, and thus obtaining the ointment. The formula accords with the principle of a prescription formula, and the ointment has the effects of diminishing swelling, relieving pain, relaxing muscles and stimulating blood circulation; and the ointment effectively relieves various pains caused by the lumbar disc herniation, rheumatism or rheumatoid, strain or bruise, hyperostosis, cancers and the like.

The invention relates to musk cream for promoting blood circulation to remove blood stasis and a hot press molding method thereof. The musk cream for promoting blood circulation to remove blood stasisis prepared from the following components in parts by weight: 1-3 parts of muskone, 8-12 parts of boric acid, 5-8 parts of camphor, 30-35 parts of sanguis draconis, 15-20 parts of urea, 110-120 partsof belladonna fluid extract, 4-7 parts of diphenhydramine hydrochloride, 10-14 parts of procaine hydrochloride, 400-500 parts of an extract for promoting blood circulation to remove blood stasis, 2000-2100 parts of rubber, 900-1000 parts of rosin, 2600-2700 parts of zinc oxide, 210-230 parts of lanolin, 90-110 parts of petroleum jelly and 260-280 parts of 95% ethanol. The hot press method comprises the steps of cutting a sizing material, refining the sizing material, kneading, filtering, baking the sizing material and gluing. The musk cream for promoting blood circulation to remove blood stasis, prepared by the method disclosed by the invention, is easy for gluing because the sizing material is soft, a product has great cohesive force and strengthened adhesion, and has no residual residueon skin after application, and the curative effect is good; a preparation process is simple, achieves high production efficiency and low cost, can meet safe production conditions, and is suitable formass production.

The invention discloses musk cream with a cardiodynia relieving function and a preparation method of the musk cream. The musk cream comprises components in parts by mass as follows: 4-7 parts of musk, 6-10 parts of angelica dahurica liquid extract, 6-10 parts of Chinese honeylocust abnormal fruit liquid extract, 5-8 parts of methyl salicylate, 5-8 parts of borneol, 2-5 parts of camphor and 4-7 parts of diphenhydramine hydrochloride. A prepared product has remarkable efficacy and stable performance, the preparation technology is simple and has few procedures, and the cost is low.

The invention relates to application of a compound pseudoephedrine hydrochloride tablet to preparation of a medicine for treating asthma. The compound pseudoephedrine hydrochloride tablet is prepared from pseudoephedrine hydrochloride, dextromethorphan hydrobromide, diphenhydramine hydrochloride, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone, magnesium stearate and dextrin; the compound pseudoephedrine hydrochloride tablet is used for relaxing tracheal smooth muscle through blocking an L-shaped calcium channel and a non-selective cation channel and can be used as a novel tracheal dilating medicine for treating diseases including asthma and the like. The compound pseudoephedrine hydrochloride tablet provided by the invention is good in pharmacological action and high in active component safety, and a novel and safe asthma treatment medicine is provided for clinic.

The invention discloses a swelling and pain relieving ointment, relates to the technical field of external ointment and aims to solve the problems that existing ointments have single components and cannot remove root causes. The ointment is prepared from raw materials as follows: Vaseline, erythromycin, mupirocin, borneol, iodine tincture, glycerin, laurocapram, procaine hydrochloride, diphenhydramine hydrochloride and traditional Chinese medicine composition. The invention also discloses a preparation method of the swelling and pain relieving ointment. The prepared ointment is fine in appearance, easy to coat, medium in thickness and resistant to cold and heat and has the functions of promoting healing of ulcer wounds and removing abscess, Vaseline is used as a matrix, borneol fully playsthe role in relieving pain and promoting granulation, iodine tincture and erythromycin inhibit bacteria and diminish inflammation, traditional Chinese medicines are added for matched use, so that theointment has effects of dredging collaterals, reducing phlegm, resolving masses, promoting blood circulation to remove blood stasis and relieving swelling and pain, western medicines and traditionalChinese medicines have a synergistic effect, the swelling and pain relieving effect is better, and the ointment has wide market prospects.