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Method for measuring content of diphenhydramine hydrochloride

A technology of diphenhydramine hydrochloride and content, applied in the field of electroanalytical chemistry, can solve the problems of complex operation, wide linear range, complex sample processing and the like

Inactive Publication Date: 2013-02-06
DALIAN UNIV
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Problems solved by technology

[0003] At present, the methods for determining the content of diphenhydramine hydrochloride are mainly based on high performance liquid chromatography and ultraviolet spectrophotometry, but these methods need to carry out complex processing of samples before determination, and the linear range is not wide, and the processing of samples is limited. very demanding
In addition, these instruments are expensive, complicated to operate, and the drug analysis process has secondary environmental pollution and high analysis costs.

Method used

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  • Method for measuring content of diphenhydramine hydrochloride
  • Method for measuring content of diphenhydramine hydrochloride
  • Method for measuring content of diphenhydramine hydrochloride

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Embodiment Construction

[0009] The present invention will be described in detail below in conjunction with the examples, but the following examples are only preferred embodiments of the present invention, and the scope of protection of the present invention is not limited thereto, and any person familiar with the technical field of the present invention is within the technical scope disclosed in the present invention Within the technical scheme of the present invention and its inventive concept, any equivalent replacement or change shall be covered within the protection scope of the present invention.

[0010] Preparation of total ionic strength adjustment buffer solution (TISAB): Add 500mL deionized water, 25mL glacial acetic acid, 58g sodium chloride and 12g sodium citrate into a 1000mL beaker, and stir until completely dissolved. Put the beaker in a cold water bath, slowly add sodium hydroxide solution (6mol / L) and stir carefully, and test it with a PHS-2C precision acidity meter (Shanghai Precisio...

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Abstract

The invention provides a method for measuring the content of diphenhydramine hydrochloride. Compared with the traditional method, the method has the advantages of simpleness in experimental apparatus, low testing cost, convenience, rapidness, more accuracy in measuring results, wider linear range and higher sensitivity, and is a simplest and most feasible method for measuring the content of the diphenhydramine hydrochloride.

Description

technical field [0001] The invention belongs to the technical field of electroanalytical chemistry, and in particular relates to a method for determining the content of diphenhydramine hydrochloride, in particular to a method for determining the content of active ingredients in diphenhydramine hydrochloride medicines. Background technique [0002] The chemical name of diphenhydramine hydrochloride is N,N-dimethyl-2-(diphenylmethoxy)ethylamine hydrochloride, which is an antiallergic drug that blocks H1 receptors by ethanolamines, and its central inhibitory effect Significantly, it has sedative, anti-sickness and antiemetic effects. It is used for motion sickness, nausea and vomiting. It also has anticholinergic effect and can relieve bronchial smooth muscle spasm. It is also used for various allergic skin diseases, such as urticaria, Insect bites. [0003] At present, the methods for determining the content of diphenhydramine hydrochloride are mainly based on high-performanc...

Claims

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Application Information

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IPC IPC(8): G01N27/26G01N27/333
Inventor 弓晓杰申贵隽洪雅蓉高春鑫种月英华欣
Owner DALIAN UNIV
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