Application of compound pseudoephedrine hydrochloride tablet to preparation of medicine for treating asthma

A technology of compound prescription and Fen tablets, applied in the field of medicine, can solve problems such as hypokalemia, cardiac rhythm disorder, single use, and excessive application

Inactive Publication Date: 2016-11-16
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Both hormone drugs and β2-receptor agonist drugs have adverse reactions. Long-term oral administration of hormones can cause osteoporosis, hypertension, diabetes, suppression of the hypothalamus-pituitary-adrenal axis, obesity, cataracts, glaucoma, etc.; β2-receptor agonists need to be used intermittently in clinical use, and should not be used for a long time, single use, or excessive application, otherwise it may cause adverse reactions such as skeletal muscle tremor, hypokalemia, cardiac rhythm disorder, etc., and there are certain disadvantages

Method used

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  • Application of compound pseudoephedrine hydrochloride tablet to preparation of medicine for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 compound pseudomamefen tablets

[0018] (1) Pseudoephedrine hydrochloride, dextromethorphan hydrobromide, diphenhydramine hydrochloride, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone, magnesium stearate and dextrin were pulverized respectively, and passed through a 40-mesh sieve;

[0019] (2) Mix 3 g of pseudoephedrine hydrochloride, 1.5 g of dextromethorphan hydrobromide, 2.5 g of diphenhydramine hydrochloride, 0.75 g of low-substituted hydroxypropyl cellulose, 0.45 g of polyvinylpyrrolidone, and 6.5 g of dextrin;

[0020] (3) 3g magnesium stearate is added in the mixture of step (2), mix homogeneously;

[0021] (4) the mixture that step (3) obtains with 10kg / mm 2 Compression tableting, prepare 100 compound pseudo-mamefene tablets.

Embodiment 2

[0022] The preparation of embodiment 2 compound pseudomamefen tablets

[0023] (1) Pseudoephedrine hydrochloride, dextromethorphan hydrobromide, diphenhydramine hydrochloride, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone, magnesium stearate and dextrin were pulverized respectively, and passed through a 40-mesh sieve;

[0024] (2) Mix 3 g of pseudoephedrine hydrochloride, 1.5 g of dextromethorphan hydrobromide, 2.5 g of diphenhydramine hydrochloride, 0.75 g of low-substituted hydroxypropyl cellulose, 0.45 g of polyvinylpyrrolidone, and 6.5 g of dextrin;

[0025] (3) 3g magnesium stearate is added in the mixture of step (2), mix homogeneously;

[0026] (4) the mixture that step (3) obtains with 8kg / mm 2 Compression tableting, prepare 100 compound pseudo-mamefene tablets.

Embodiment 3

[0027] Non-clinical pharmacodynamics study of embodiment 3 compound pseudomamefen tablets

[0028] 1. Experimental materials

[0029] 1.1 Experimental animals

[0030] Sexually mature and healthy male Kunming mice, with an average age of 8 weeks, were purchased from Hubei Provincial Center for Disease Control and Prevention. The mice were kept at room temperature of 20-25° C. and humidity of 50-60%, and the light-dark cycle interval was 12 hours.

[0031] 1.2 Experimental instruments and reagents

[0032] Compound Pseudomamefen Tablets (self-made); Absolute Ethanol (Sinopharm Chemical Reagent Co., Ltd.);

[0033] Nifedipine (U.S. Sigma Company); Pyrazole 3 (U.S. Sigma Company);

[0034] Acetylcholine (Sigma, USA);

[0035] Stereo microscope (Wuhan Aispei Scientific Instrument Co., Ltd.);

[0036] Ice machine (Chongzhou Shubo Chemical Co., Ltd.);

[0037] Erlenmeyer flask (Chongzhou Shubo Chemical Co., Ltd.);

[0038] HV-4 type constant temperature perfusion system for ...

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Abstract

The invention relates to application of a compound pseudoephedrine hydrochloride tablet to preparation of a medicine for treating asthma. The compound pseudoephedrine hydrochloride tablet is prepared from pseudoephedrine hydrochloride, dextromethorphan hydrobromide, diphenhydramine hydrochloride, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone, magnesium stearate and dextrin; the compound pseudoephedrine hydrochloride tablet is used for relaxing tracheal smooth muscle through blocking an L-shaped calcium channel and a non-selective cation channel and can be used as a novel tracheal dilating medicine for treating diseases including asthma and the like. The compound pseudoephedrine hydrochloride tablet provided by the invention is good in pharmacological action and high in active component safety, and a novel and safe asthma treatment medicine is provided for clinic.

Description

technical field [0001] The invention relates to the application of compound pseudomamefene tablets in the preparation of medicines for treating asthma, belonging to the technical field of medicine. Background technique [0002] Asthma is a highly sensitive disease of the airway caused by external or certain allergens present in the human body. Extensive reversible spasm and stenosis of the trachea due to oversensitivity of the trachea to irritants. The clinical manifestation is paroxysmal dyspnea with wheezing, which lasts for several minutes to several hours, and improves after treatment or spontaneously. [0003] At present, asthma treatment should adopt comprehensive treatment methods, including: avoiding contact with allergens and other asthma triggers, standardized drug treatment, specific immunotherapy and patient education. Among them, drug therapy includes controlling drugs and relieving drugs. Specific drugs include hormones, leukotriene modulators, β2-receptor a...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/485A61P11/06A61K31/135A61K31/137
CPCA61K31/485A61K9/2027A61K9/2054A61K9/2059A61K31/135A61K31/137A61K2300/00
Inventor 于孟飞陈思琪沈金花马琳
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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