Joint pain relieving gel and preparation method thereof

A joint and gel technology, applied in the field of medicine, can solve problems such as poor centrifugal and thermal stability, and delamination

Inactive Publication Date: 2015-09-23
ANHUI ANKE YULIANGQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The applicant previously applied for an invention patent (application number 201310631458.2) titled "Huoxuezhipain gel and its preparation method". , referring to the technical scheme disclosed in this patent, the applicant tried to combine the drug composition of the joint pain relief ointment with the matrix components (i.e. triethanolamine, carbomer, ethyl paraben, hydroxypropyl methyl cellulose, glycerin, ethanol, azone and water) are combined to prepare the joint pain relief gel, but the test finds that after the medicinal extract prepared by the above-mentioned technical scheme is mixed with the matrix, the centrifugal and thermal stability are relatively poor, Stratification occurs

Method used

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  • Joint pain relieving gel and preparation method thereof
  • Joint pain relieving gel and preparation method thereof

Examples

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preparation example Construction

[0016] The preparation method of above-mentioned joint pain relief gel, comprises the following steps:

[0017] a, take by weighing peppermint oil, methyl salicylate, camphor, diphenhydramine hydrochloride, capsicum liquid extract and belladonna liquid extract, mix and stir to obtain medicinal extract;

[0018] b. Sprinkle carbomer into 40-200 parts of water, place it, and stir after it is fully swollen to obtain carbomer gel A;

[0019] c. Add 10-100 parts of water to the hydroxypropyl methylcellulose and polyvinyl alcohol, heat and stir until dissolved, then add glycerin and stir well to obtain colloidal liquid B;

[0020] d, weigh ethylparaben and azone, add 1-10 parts by mass of 85%-90% ethanol to dissolve, then mix with the medicinal extract prepared in step a, stir well to obtain mixed medicinal solution C ;

[0021] e. Mix carbomer gel A and colloidal liquid B, add 20-200 parts of water, stir well, then add mixed liquid C, stir well, add triethanolamine, add water to ...

Embodiment 1

[0041] Example 1: Preparation of Joint Pain Relief Gel

[0042] 1) take capsicum by weighing, pulverize into coarse powder, add 1 times of mass fraction to the capsicum coarse powder and be 85% ethanol (that is to say the addition quality of ethanol is 1 times of capsicum coarse powder), soak for 2 days, infiltrate Drain, collect the percolate and filter, then concentrate the filtrate under reduced pressure to a relative density of 1.30g / ml at 30°C to obtain capsicum fluid extract;

[0043] 2) Weighing belladonna, crushing it into belladonna coarse powder, adding 2 times the mass fraction of 85% ethanol to the belladonna coarse powder, soaking for 2 days, percolating, collecting the percolating liquid and filtering, Recover ethanol under reduced pressure, cool naturally to room temperature, separate and remove chlorophyll, filter, concentrate the filtrate under reduced pressure to a thick shape, then add 10 times the mass fraction of 85% ethanol for precipitation, absorb the s...

Embodiment 2

[0049] Example 2: Preparation of Joint Pain Relief Gel

[0050] 1) Weigh the pepper, crush it into coarse powder, add 3 times of ethanol with a mass fraction of 85% to the pepper coarse powder, soak for 3 days, percolate, collect the percolation liquid and filter, and then put The filtrate was concentrated under reduced pressure to a relative density of 1.30 g / ml to obtain capsicum liquid extract;

[0051] 2) Take belladonna, crush it into belladonna coarse powder, add 3 times the mass fraction of 85% ethanol to the belladonna coarse powder, soak for 3 days, percolate, collect the percolation liquid and filter, Recover ethanol under reduced pressure, cool naturally to room temperature, separate and remove chlorophyll, filter, concentrate the filtrate under reduced pressure to a thick shape, then add 10 times the mass fraction of 85% ethanol for precipitation, absorb the supernatant, and store at 30°C Concentrate the supernatant under reduced pressure to a thick paste with a r...

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Abstract

The invention relates to the medicine field and specifically discloses an arthralgia relieving gel. The arthralgia relieving gel is prepared from raw materials including the following components in parts by weight: 160-240 parts of capsicum fluid extract, 90-140 parts of atropa belladonna fluid extract, 30-50 parts of dementholized peppermint oil, 70-90 parts of methyl salicylate, 160-240 parts of camphor, 10-15 parts of diphenhydramine hydrochloride, 1-10 parts of triethanolamine, 2-30 parts of carbomer, 1-3 parts of ethylparaben, 3-40 parts of hydroxypropyl methylcellulose, 50-100 parts of glycerin, 1-10 parts of ethanol, 1-5 parts of azone and a proper quantity of water; all the raw material components are of 1000 parts in total. The invention also discloses a preparation method of the arthralgia relieving gel. Compared with the existing arthralgia relieving plaster in the prior art, the arthralgia relieving gel has the advantages of good stability, easy absorption, remarkable medical effect, low skin irritation and safe production.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a gel for joint pain relief and a preparation method thereof. Background technique [0002] Joint Pain Relief Ointment is a Chinese patent medicine that has been on the market for many years. The prescription includes six flavors of capsicum, belladonna, peppermint oil, methyl salicylate, camphor, and diphenhydramine hydrochloride. It is used to treat rheumatic arthralgia and joint sprains caused by cold-damp stasis blocking the meridian, with remarkable curative effect. For its quality standard, see page 705 of the 2010 edition of "Chinese Pharmacopoeia". But the joint pain relief ointment is a rubber ointment, which uses natural rubber as the skeleton material and rosin as the tackifier. These materials have strong irritation and allergies to the skin, excessive adhesion, poor air permeability, and poor patient compliance. Thereby hindered the clinical application of joint pain ointme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/06A61P19/02A61P29/00A61K31/618A61K31/135A61K31/125
Inventor 刘道芳刘海兵谢红星田湘玲徐莉莉廖华宁
Owner ANHUI ANKE YULIANGQING PHARMA
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