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External use plaster used for easing pain and strengthening bone

A technology of plaster and extract, applied in bone diseases, non-central analgesics, medical raw materials derived from Mahuangmen, etc., can solve problems such as poor targeting and unsatisfactory efficacy, and achieve easy absorption and good transdermal absorption. The effect of uniform rate and quality

Active Publication Date: 2017-12-12
杭州仁德药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of poor pertinence and unsatisfactory drug efficacy of some plasters, the object of the present invention is to provide an external plaster for analgesic and bone strengthening, which has a very obvious effect of analgesic and bone strengthening, and has good transdermal Absorption rate, quick effect, the active ingredients in the plaster are not easy to volatilize, the plaster has good viscosity and uniform quality

Method used

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  • External use plaster used for easing pain and strengthening bone
  • External use plaster used for easing pain and strengthening bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] An external plaster for analgesia and bone strengthening, which is prepared from the following components: Kaempferia liquid extract 100g, musk 0.24g, menthol 40g, methyl salicylate 25.5g, leopard bone 0.3g, sulfuric acid Chondroitin 4.8g, Borneol 30g, Diphenhydramine Hydrochloride 6g, Camphor 30g, Zinc Oxide 520g, Rosin 320g, Lanolin 50g, Vaseline 40g, Transdermal Accelerator 70g, Tackifier 40g, Emulsifier 30g, Rubber 390g.

[0033] Among them, the liquid extract of Shannai is prepared through the following process: 50g of Shannai, 40g of star anise, 60g of Shengchuanwu, 60g of Shengcaowu, 60g of Ephedra, 80g of Angelica dahurica, 120g of Atractylodes atractylodes, 120g of angelica, 170g of dried ginger, and impatiens. 10g, Buddleia 10g, and Rhizoma Drynariae 20g were mixed and pulverized to obtain a coarse powder, then 95% alcohol was added for heating and impregnating, and the obtained impregnating liquid was concentrated in vacuum to 35% of the original volume to obt...

Embodiment 2

[0045] An external plaster for analgesia and bone strengthening, prepared from the following components: 125g of kaempferia liquid extract, 0.30g of musk, 50g of menthol, 32g of methyl salicylate, 0.38g of leopard bone, cartilage sulfate 6.0g of prime, 37.5g of borneol, 7.5g of diphenhydramine hydrochloride, 37.5g of camphor, 650g of zinc oxide, 400g of rosin, 62.5g of lanolin, 50g of petrolatum, 95g of transdermal accelerator, 65g of tackifier, 50g of emulsifier, Rubber 490g.

[0046] Among them, the liquid extract of Shannai is prepared through the following process: 62.5g of Shannai, 50g of star anise, 75g of Shengchuanwu, 75g of Shengcaowu, 75g of Ephedra, 100g of Angelica dahurica, 150g of Atractylodes atractylodes, 150g of angelica, 210g of dried ginger, Impatiens Mix 12.5g of stems, 12.5g of Buddleia, and 27.5g of Rhizoma Rhizoma Rhizoma Rhizoma Drynariae to obtain coarse powder, then add 95% alcohol to heat and impregnate, and vacuum concentrate the obtained impregnati...

Embodiment 3

[0058] An external plaster for analgesia and bone strengthening, prepared from the following components: 150g of kaempferia liquid extract, 0.36g of musk, 60g of menthol, 38g of methyl salicylate, 0.45g of leopard bone, cartilage sulfate 7.2g of prime, 45g of borneol, 9g of diphenhydramine hydrochloride, 45g of camphor, 780g of zinc oxide, 480g of rosin, 75g of lanolin, 60g of petrolatum, 120g of transdermal accelerator, 90g of tackifier, 70g of emulsifier, and 585g of rubber.

[0059] Among them, the liquid extract of Shannai is prepared through the following process: 750g of Shannai, 60g of star anise, 90g of Shengchuanwu, 90g of Shengcaowu, 90g of ephedra, 120g of Angelica dahurica, 180g of atractylodes, 180g of angelica, 255g of dried ginger, and impatiens. 15g, Buddleia 15g, and Rhizoma Drynariae 35g were mixed and pulverized to obtain a coarse powder, then 95% alcohol was added for heating and impregnated, and the obtained impregnating solution was concentrated in vacuum ...

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PUM

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Abstract

The invention belongs to the technical field of plaster preparations and particularly relates to an external use plaster used for easing pain and strengthening the bone. The external use plaster is prepared from a rhizoma kaempferiae fluid extract, musk, menthol, methyl salicylate, a leopard bone, chondroitin sulfate, borneol, diphenhydramine hydrochloride, camphor, zinc oxide, rosin, wool fat, vaseline, a transdermal enhancer, a tackifier, an increasing milk agent, and a rubber; the transdermal enhancer comprises a monarch drug and an adjuvant, wherein the monarch drug is combination of N-dimethylamino n-butyrate dodecyl ester and one of alpha-bisabolol, ferulic acid and glycerinum monopentyl ether, and the adjuvant is methyl trioctyl ammonium chloride or bromo-1-butyl-3-methyl-imidazole. The external use plaster has a very obvious effect of easing pain and strengthening the bone, has excellent transdermal absorptivity at the same time and takes effects quickly, the effective ingredients in the plaster do not volatilize easily, the viscidity of the plaster is good, and the quality is even. Meanwhile, the ingredients of the plaster are much easier to absorb by the skin after an emulsified slurry is made and gelatinized.

Description

technical field [0001] The invention belongs to the technical field of plaster preparations, in particular to an external plaster for relieving pain and strengthening bones. Background technique [0002] Plasters have a long history of application in our country. Vegetable or animal oils are added to make a jelly-like substance, which can be pasted on the affected area for a long time on one side of cloth, paper or leather. The medicine in the plaster is directly applied to the acupuncture points on the body surface. , the property of the medicine permeates the subcutaneous tissue from the surface to the inside through the fur. On the one hand, the relative advantage of the drug concentration is produced locally. So as to exert the greatest systemic pharmacological effect. Traditional injection and oral therapy damage nerves, blood vessels, muscles and other tissues, making it difficult for patients to accept, and these methods are easy to disperse the medicine through the ...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61K36/9068A61K9/70A61P29/00A61P19/08A61K31/045A61K31/125A61K31/135A61K31/618A61K31/737A61K35/32A61K35/55
CPCA61K9/7076A61K31/045A61K31/125A61K31/135A61K31/618A61K31/737A61K35/32A61K35/55A61K36/126A61K36/17A61K36/185A61K36/232A61K36/284A61K36/56A61K36/57A61K36/714A61K36/906A61K36/9068A61K2300/00
Inventor 俞帮和徐明蒋志刚汪海涛
Owner 杭州仁德药业股份有限公司
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