The invention provides a skin bacteriostatic cream and a preparation process thereof. The skin bacteriostatic cream comprises the following raw materials: radix angelicae sinensis, radix sophorae flavescentis, radix et rhizoma rhei, cortex phellodendri, fructus bruceae, cassytha filiformis, radix notoginseng, radix scutellariae, radix angelicae dahuricae, rhizoma chuanxiong, radix salviae miltiorrhizae, mirabilitum, white pearl and chlorhexidine acetate. The skin bacteriostatic cream has the beneficial effects that after the traditional Chinese medicine extract is prepared into an ointment for transdermal administration, the content of effective components of the medicine at the unit area of the epidermis can be increased, and the medicine effect is improved; meanwhile, by selecting a proper ointment type, the activity of the effective components of the traditional Chinese medicine extract can be protected, and inactivation or failure of the effective components in the long-term storage process is prevented, so that the skin bacteriostatic cream is superior to injection and oral therapy, medicine powder smearing and the like for skin diseases, can be used for various skin diseases, and is good in curative effect, quick in effect and free of side effects; and the skin bacteriostatic cream prepared by the preparation process of the skin bacteriostatic cream is good in smearing skin feeling, heat resistance, cold resistance and long-term stability.