Ibuprofen diphenhydramine dispersing tablet and preparation method thereof

A technology of diphenhydramine citrate and dispersible tablets, which is applied in the field of pharmacy, can solve the problems of no research reports on ibuprofen diphenhydramine dispersible tablets and no products on the market, and achieve stable and controllable quality and prescription Reasonable design and low cost effect

Active Publication Date: 2012-06-13
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no research reports on ibuprofen diphenhydramine dispersible tablets at home and abroad, and no related products are listed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription:

[0030] components mass (g) Mass percentage (%) ibuprofen 200 40 Diphenhydramine hydrochloride 25 5 microcrystalline cellulose 90 18 pregelatinized starch 110 22 Croscarmellose Sodium 37 7.4 Povidone K30 20 4 Sodium dodecyl sulfate 1 0.2 Magnesium stearate 8 1.6 Micropowder silica gel 5 1 aspartame 3 0.6 stevia 1 0.2 gross weight 500 100

[0031] Preparation:

[0032] a. Each component in the prescription is pulverized into the fine powder of crossing 100 mesh sieves respectively; The povidone K30 of recipe quantity is dissolved in water and made the solution that mass percent concentration is 2%;

[0033] b. Take prescription amounts of ibuprofen, microcrystalline cellulose, pregelatinized starch, and sodium lauryl sulfate, and three-quarters prescription amounts of croscarmellose sodium, aspartame, and stevia, Mix evenly, add povidone K30 solution with...

Embodiment 2

[0039] prescription:

[0040] components mass (g) Mass percentage (%) ibuprofen 200 40 Diphenhydramine hydrochloride 25 5 microcrystalline cellulose 60 12 lactose 90 18 pregelatinized starch 47 9.4 Croscarmellose Sodium 30 6 Crospovidone 10 2 Povidone K30 15 3 Sodium dodecyl sulfate 2 0.4 Magnesium stearate 8 1.6 Micropowder silica gel 8.5 1.7 aspartame 3 0.6 stevia 1.5 0.3 gross weight 500 100

[0041] Preparation:

[0042] a. Each component in the prescription is pulverized into the fine powder of crossing 100 mesh sieves respectively; The povidone K30 of recipe quantity is dissolved in water and made the solution that mass percent concentration is 2%;

[0043] b. Take prescription amounts of ibuprofen, microcrystalline cellulose, pregelatinized starch, lactose, and sodium lauryl sulfate, and three-quarters of croscarmellose sodium, crospovidone, aspirin Mix...

Embodiment 3

[0049] prescription:

[0050] components mass (g) Mass percentage (%) ibuprofen 200 40 diphenhydramine citrate 38 7.6 microcrystalline cellulose 125 25 Mannitol 55 11 Croscarmellose Sodium 30 6 Povidone K30 30 6 Sodium dodecyl sulfate 1 0.2 Magnesium stearate 9 1.8 Micropowder silica gel 5 1 aspartame 5 1 stevia 2 0.4 gross weight 500 100

[0051] Preparation:

[0052] a. Each component in the prescription is pulverized into the fine powder of crossing 100 mesh sieves respectively; The povidone K30 of recipe quantity is dissolved in water and made the solution that mass percent concentration is 2%;

[0053] b. Take the prescribed amount of ibuprofen, microcrystalline cellulose, mannitol, and sodium lauryl sulfate, and three-quarters of the prescribed amount of croscarmellose sodium, aspartame, and stevia, and mix well. Add povidone K30 solution with a mass percentage concen...

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Abstract

The invention provides an ibuprofen diphenhydramine dispersing tablet, which consists of the following components in percentage by mass: 40 percent of ibuprofen, 5 percent of diphenhydramine hydrochloride or 7.6 percent of diphenhydramine citrate, 30-43 percent of a filler, 5-15 percent of a disintegrant, 2-8 percent of a bonding agent, 0.1-1 percent of a surfactant, 1.5-4 percent of a lubricating agent and 0.5-1.5 percent of a flavoring agent, wherein the filler is at least two of microcrystalline cellulose, pre-gelatinized starch, lactose and mannite; the disintegrant is cross-linked sodiumcarboxymethylcellulose and / or cross-linked polyvidone; the bonding agent is polyvidone K30; the surfactant is sodium dodecyl sulfate; the lubricating agent is magnesium stearate and superfine silica gel powder; and the flavoring agent is aspartame and steviosin. The invention further provides a preparation method of the dispersing tablet. The preparation method is easy and convenient to operate, has low cost, and is suitable for industrial production. An obtained product has stable and controllable quality, attractive appearance, good mouthfeel and proper hardness, is fully disintegrated in water at the temperature of 20+ / -1 DEG C within 3 minutes, and passes through a No.2 sieve; and the medicament dissolvability is over 85 percent 30 minutes later.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a pharmaceutical preparation and a preparation method of the preparation. Background technique [0002] Pain is a symptom associated with many diseases, and it is also a disease with multiple characteristics such as physiology, psychology and society. Pain can be caused by many reasons, and usually it is mainly caused by noxious stimuli that cause tissue damage, such as mechanical stimuli such as knife cutting and stick hitting, as well as noxious stimuli caused by electric current, strong acid, and strong alkali. Pain can be further divided into sharp pain and dull pain. Sharp pain has a stronger sense of pain and a shorter duration, such as tingling pain, cramping pain, burning pain and electric shock-like pain, etc. It is more common in trauma, surgery, inflammation, visceral injury and malignant tumors. Dull pain is milder and lasts longer, such as distending pain, dull pain, soreness ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K31/135A61K9/20A61P29/00A61P25/20A61P25/04
Inventor 罗永煌罗敏张玉洁罗玲艳陈琪翁国媛
Owner SOUTHWEST UNIV
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