173results about How to "Product quality is stable and controllable" patented technology

The invention relates to a preparation method for directly producing enoxaparin sodium from crude product heparin sodium. The preparation method comprises the following steps of: taking the crude product heparin sodium as a raw material, performing fractionated precipitation through an organic solvent to remove most of impurities in the crude product heparin sodium, and then removing part of residual impurity proteins, pigments and other impurities by oxidation through hydrogen peroxide so as to get the high-purity heparin sodium which is in line with the production requirements of the enoxaparin sodium; and taking the high-purity heparin sodium as an intermediate product, preparing a heparin quaternary ammonium salt, preparing heparin benzyl ester, performing alkaline depolymerization on the heparin benzyl ester, neutralizing with an acid, performing alcohol precipitation, refining, decoloring, dehydrating and drying to get an enoxaparin sodium finished product. By adopting the method disclosed by the invention, the use of the organic solvent is greatly reduced, the production efficiency is improved, the influences on the environment are reduced, the enoxaparin sodium finished product which achieves or is better than European Pharmacopoeia 7.0 version is obtained, and the method is simple to operate and can realize industrialized production.

The invention belongs to the liquor production field, in particular to a preparation method of Maotai-flavor liquor. The method of the invention comprises the following steps: a. fermented grains or double bottom fermented grains which are not extracted wine in the production process of common Maotai-flavor liquor are added to Maotai-flavor liquor yeast powder and mature hull for uniformly blending, and then adding fluid is added to acquire Maotai-flavor flavoring wine fermented grains; b. the fermented grains produced by common Maotai-flavor liquor is cellared, and the Maotai-flavor flavoring wine fermented grains acquired from step a is placed on the top; c. cellar mud is used for sealing the cellar, the Maotai-flavor flavoring wine fermented grains is taken out after fermentation to distill and extract wine, thus acquiring the wine. The method of the invention has simple steps and low cost, the product manufactured by the method has intense and mellow Maotai-flavor style, and the taste is better than the Maotai-flavor liquor prepared by the existing method, thereby having great application prospect.

The invention relates to a preparation method and a quality control method for a compound indigowoad leaf preparation. The preparation method comprises a step of preparing a basic remedy and a step of preparing a corresponding preparation. The basic remedy in the basic remedy preparation comprises the following compositions in part by weight: 360 to 440 parts of indigowoad leaves, 180 to 220 parts of lonicera confusa or honeysuckle flower, 90 to 110 parts of incised notopterygium rhizome, 90 to 110 parts of bistort rhizome, and 90 to 110 parts of rhubarb; the medicinal materials are decocted twice with conventional amount of water for 1 hour each time; the decoctions are mixed and filtered; the filtrate is concentrated to the relative density of between 1.08 and 1.32 at 60 DEG C; ethanol is added into the filtrate to ensure that alcohol content reaches 50 to 60 percent, the mixture is stood and is filtered, the filtrate is subjected to ethanol reclamation and is concentrated to an extract with the relative density of between 1.17 and 1.43 at 60 DEG C for later use; and the corresponding preparation is prepared according to a drug specification. The quality control method comprises the following steps of the identification of contents and the content determination of the contained compositions including the identification of the indigowoad leaves, the identification of the lonicera confusa or honeysuckle flower, the identification of the rhubarb, the identification of the incised notopterygium rhizome, the total content determination of emodin and chrysophanol in the rhubarb, and the content determination of chlorogenic acid. The methods can be applied to preparation of medicinal preparations for treating cold, influenza, parotitis and acute viral hepatitis.

A self-assembled precursor liposome of taxusol is proportionally prepared from tausol, phosphatide, polyethylene glycol and dispersing medium through mixing, dispersing, press-filtering by millipore film, and pouring it in a container full of N2.

The invention relates to a high-purity ginkgolide and its composition. It is a white powder with slightly bitter taste. The content of ginkgolide A is 10-20%, the content of ginkgolide B is 10-20%, and the content of ginkgolide C is 10-20%. 5-15%, the bilobalide content is 30-50%, and the total lactone content is 80-95%. Ginkgo biloba is used as raw material, heated and refluxed with ethanol solution with a mass fraction of 20-80% to extract, the extract is concentrated to recover ethanol, separated by a macroporous resin column, desorbed by ethanol, diluted with water, and then passed through a gel-type hydrogen bond Adsorption and desorption of the adsorption resin, collection of effluent and desorption liquid, concentration, drying, ethanol dissolution, activated carbon decolorization, concentration and drying. The preparation process is simple, reliable, low in cost and high in yield, and no toxic organic solvent is used in the process, which is an environment-friendly process. The high-purity ginkgolide is used as an active ingredient to prepare a composition that can be used as various preparations (capsules, tablets, oral liquids, granules, powders, injections, etc.) of ginkgolide medicines or health care products.

The invention discloses a calcium dobesilate capsule and a preparation method thereof. The calcium dobesilate capsule is prepared from calcium dobesilate, croscarmellose sodium, magnesium stearate and polyvinyl pyrrolidone, wherein every 1000 calcium dobesilate capsules contain 500g of calcium dobesilate, 20-50g of croscarmellose sodium and 2-6g of magnesium stearate. In addition, a traditional preparation method is improved in the invention, and the improved method comprises the following steps: on the basis of taking the croscarmellose sodium as a disintegrating agent and taking the magnesium stearate as a lubricating agent, adding a proper amount of the polyvinyl pyrrolidone to prepare a bonding agent; preparing the bonding agent and the calcium dobesilate as well as the croscarmellosesodium into granules by a multi-step granulation method; and spraying the ethanol solution of the magnesium stearate onto the surfaces of the granules to obtain calcium dobesilate capsules with stable quality, high dissolution rate and small content uniformity.

The invention for new flavan derivate with preparation method and application relates to extract and separate to obtain the product from Pithecellibium Clypearia Benth. The structure formula is shown as right with R as H or gallicacyl. This invention can be used in preparing antivirus drug.

The invention relates to the technical field of intelligent manufacturing, and specifically relates to a cloud intelligent manufacturing system based on a public cloud. The cloud intelligent manufacturing system includes a MES system that achieves interaction of cloud production data collected by a public cloud with a production system through production modeling and industrial big data analysis,and achieves intelligent control of cloud production; an intelligent perception module that exchanges data with an application module and the MES system through an ethernet communication module of a PLC, receives data instructions transmitted by an OPC for automatic production control and process adjustment while feeding back a status of each device; a communication module that is used to provideinternet services for the intelligent perception module, the application module and a model module to achieve data interaction; and a model module that is used for data interaction with the intelligent perception module, thereby achieving intelligent production.

The invention discloses a preparation method of an arginine dexibuprofen raw medicine. The method comprises the steps of: dissolving dexibuprofen in ethanol, heating the mixture to a temperature of 50DEG C-60DEG C, adding L-arginine in a dropwise manner slowly and continuously under stirring within 10min-20min, continuing stirring for reaction for 2h-3.5h with the temperature maintained at 50DEG C-60DEG C, leaving the mixture to stand for 25min-35min and cool to a temperature of 18DEG C-30DEG C, conducting pumping filtration so as to obtain crystals, then washing and drying the crystals, thus obtaining white crystals, i.e. arginine dexibuprofen. The preparation method of the invention has simple process, high yield, no refining step, shortened production period, and no need for any special equipment, thus being suitable for industrial production.

The present invention discloses a lithium hydroxide monohydrate preparation system, which comprises: a carbonization impurity removing device provided with a crude lithium carbonate inlet, a water inlet, a carbon dioxide inlet, an EDTA inlet and a refined lithium carbonate outlet; a causticization device provided with a refined lithium carbonate inlet, a lime milk inlet and a lithium hydroxide completion liquid outlet; an ion exchange device provided with a lithium hydroxide completion liquid inlet and a refined lithium hydroxide purification liquid outlet; an evaporation crystallization device provided with a refined lithium hydroxide purification liquid inlet and a crude wet lithium hydroxide monohydrate outlet, wherein the refined lithium hydroxide purification liquid inlet is connected to the refined lithium hydroxide purification liquid outlet; and a post-treatment device provided with a crude wet lithium hydroxide monohydrate inlet and a lithium hydroxide monohydrate outlet, wherein the crude wet lithium hydroxide monohydrate inlet is connected to the crude wet lithium hydroxide monohydrate outlet. According to the present invention, with the system, the high-purity lithium hydroxide monohydrate can be prepared by using the industrial-grade or sub-industrial-grade lithium carbonate crude product, the industrial process is stable, the quality of the product is stable and controlled, and the yield is high.

The invention relates to an inorganic fullerene molybdenum disulfide/graphene composite lubricant and a preparation method thereof. The mass ratio of molybdenum disulfide to graphene in the lubricant is 1:(0.0005-0.1), the particle size of the inorganic fullerene molybdenum disulfide is 30-300nm, and the molybdenum disulfide is uniformly dispersed on the graphene surface or in the defect clearances and bonded firmly. The preparation method is convenient and controllable for operation. Under the synergistic actions of the molybdenum disulfide and graphene, the prepared composite lubricant has excellent lubricating property, and has very important application values in the fields of solid lubricating materials, precision machinery, aerospace and the like.

The invention discloses an intelligent vertical mill control system based on a distributed control system (DCS). The intelligent vertical mill control system comprises a data collecting module, a data analysis module, the DCS module, a control module and an execution module, wherein the data collecting module is used for collecting the operating parameters of a vertical mill system in real time; the data analysis module is used for receiving the operating parameters, sent by the data analysis module, of the vertical mill system and carrying out configuration analysis and logic operation on the operating parameters of the vertical mill system so that a data analysis result can be obtained; the DCS module is used for receiving the data analysis result and generating a control instruction according to the data analysis result; the control module is used for receiving the control instruction from the DCS module and converting the control instruction to a control signal; and the execution module is used for receiving the control signal from the control module and carrying out corresponding operations according to the control signal. According to the intelligent vertical mill control system, the operating parameters of the vertical mill system are collected in time through a PLC and subjected to data analysis, the DCS module generates the corresponding control instruction, and therefore the vertical mill system is controlled.