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Preparation method of compound paracetamol and amantadine pellets

A technology of compound acetaminophen and pellets, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, amine active ingredients, etc., can solve the problems of high cost, time-consuming and labor-consuming, and complicated steps, and achieve cost-effective Low, good identification items, good dissolution rate

Active Publication Date: 2013-01-09
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the steps of this method are complicated, time-consuming and labor-intensive, and the cost is high.

Method used

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  • Preparation method of compound paracetamol and amantadine pellets
  • Preparation method of compound paracetamol and amantadine pellets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Acetaminophen 250g, amantadine hydrochloride 100g, chlorpheniramine maleate 2g, artificial bezoar 10g, caffeine 15g, dextrin 8.4g.

[0038] Preparation:

[0039] (1) Dissolve 8.4 g of dextrin of the above-mentioned adhesive in boiling water, stir evenly, and dissolve to prepare an aqueous solution of dextrin with a concentration of 25% by mass.

[0040] (2) Mix 250g of acetaminophen, 100g of amantadine hydrochloride and 10g of artificial bezoar evenly to obtain a mixed powder for use.

[0041] (3) Add 2 g of chlorpheniramine maleate and 15 g of caffeine to 17 g of ethanol to prepare a chlorpheniramine maleate caffeine solution, and add step (1) to the chlorpheniramine maleate caffeine solution The dextrin aqueous solution of 1 / 2 amount of the total mass of the dextrin aqueous solution is mixed evenly to obtain a mixed solution, which is set aside.

[0042] (4) Take 1 / 2 of the total mass of the mixed powder in step (2) and add it to the coating granulator, start the ma...

Embodiment 2

[0045] A kind of compound aminopheniramine pellet, is characterized in that, is made of following raw material:

[0046] Paracetamol 500g, amantadine hydrochloride 200g, chlorpheniramine maleate 4g, artificial bezoar 20g, caffeine 30g, dextrin 20g.

[0047] Preparation:

[0048] (1) Dissolve 20g of the above adhesive dextrin in boiling water, stir evenly, and dissolve to prepare an aqueous solution of dextrin with a concentration of 30% by mass.

[0049] (2) Mix 500g of acetaminophen, 200g of amantadine hydrochloride and 20g of artificial bezoar evenly to obtain a mixed powder for use.

[0050] (3) Add 4g of chlorpheniramine maleate and 30g of caffeine to 34g of ethanol to prepare a chlorpheniramine maleate caffeine solution, and add step (1) to the chlorpheniramine maleate caffeine solution The dextrin aqueous solution of 1 / 2 amount of the total mass of the dextrin aqueous solution is mixed evenly to obtain a mixed solution, which is set aside.

[0051] (4) Take 1 / 2 of the...

Embodiment 3

[0054] Acetaminophen 750g, amantadine hydrochloride 300g, chlorpheniramine maleate 6g, artificial bezoar 30g, caffeine 45g, dextrin 26g.

[0055] Preparation:

[0056] (1) Dissolve 26g of the above adhesive dextrin in boiling water, stir evenly, and dissolve to prepare an aqueous solution of dextrin with a concentration of 35% by mass.

[0057] (2) Mix 750g of acetaminophen, 300g of amantadine hydrochloride and 30g of artificial bezoar evenly to obtain a mixed powder, which is ready for use.

[0058] (3) Add 6g of chlorpheniramine maleate and 45g of caffeine to 51g of ethanol to prepare a chlorpheniramine maleate caffeine solution, and add step (1) to the chlorpheniramine maleate caffeine solution The dextrin aqueous solution of 1 / 2 amount of the total mass of the dextrin aqueous solution is mixed evenly to obtain a mixed solution, which is set aside.

[0059] (4) Take 1 / 2 of the total mass of the mixed powder in step (2) and add it to the coating granulator, start the main ...

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Abstract

The invention discloses a preparation method of compound paracetamol and amantadine pellets. The compound paracetamol and amantadine pellet is mainly prepared from the following raw materials: chlorpheniramine maleate, calculus bovis factitious, caffeine, amantadine hydrochloride, acetaminophen and dextrin, and the mass ratio of the above raw materials is 1 to 5 to 7.5 to 50 to 125 to (4-5); the preparation method comprises the following steps: adding the chlorpheniramine maleate and the caffeine in the form of solution into a dextrin aqueous solution, spraying and packing the mixed solution on the mixed masterbatches consisting of the acetaminophen, the amantadine hydrochloride and the calculus bovis factitious, and then spraying the rest of dextrin and the rest of mixed powder to obtain the compound paracetamol and amantadine pellet. The method is simple to operate, liable to control and suitable for industrial production, and the obtained pellet has the advantages of low related substances, good content uniformity and dissolution rate and the like.

Description

technical field [0001] The invention relates to the field of compound aminophenamine preparations, in particular to a preparation method of compound aminophenamine pellets. Background technique [0002] Compound Amantadine Capsules is a compound capsule preparation, and its main ingredients are amantadine hydrochloride, acetaminophen, chlorpheniramine maleate, artificial bezoar and caffeine. It is used for nasal congestion, runny nose, sneezing, sore throat, headache, fever, etc. caused by colds, and can also be used for the prevention and treatment of influenza. [0003] Acetaminophen in the compound acetaminophen preparation can inhibit the synthesis of prostaglandins, and has antipyretic and analgesic effects; amantadine can resist "sub-type A" influenza virus, and can inhibit virus reproduction; caffeine is a central stimulant, It can enhance the antipyretic and analgesic effects of acetaminophen, and can reduce the central inhibitory effects of drowsiness and dizziness...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/16A61P11/04A61P25/04A61P29/00A61P1/16A61K31/13A61K31/167A61K31/4402A61K31/522
Inventor 刘全国陈克领
Owner HAINAN HULUWA PHARMA GRP CO LTD
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