Poly olefinic taxadol self assembled precusor liposome and its preparation method
A technology of proliposome and docetaxel, which is applied in the directions of liposome delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of incomplete local dissolution, poor reproducibility, poor stability of preparation quality, etc., and achieves safe and The effect of easy purchase, stable and controllable quality, and stable product quality
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Embodiment 1
[0060] prescription:
[0061] Docetaxel 2g
[0062] Egg phospholipids 27.5g
[0063] Tween 80 12.5g
[0064] Cholesterol 1g
[0065] Ethanol to 100ml
[0066] Preparation process: according to figure 1 The process flow shown (the same below) dissolves the prescribed amount of lecithin in an appropriate amount of ethanol, then adds the prescribed amount of docetaxel, Tween 80, cholesterol and the remaining amount of ethanol, and after the drug and other components are completely dissolved , 0.22 μm microporous membrane filter to sterilize, under aseptic conditions, the filtrate is sealed in a nitrogen-filled ampoule or a vial to obtain the docetaxel self-assembled proliposome.
[0067] Adding the prepared docetaxel self-assembled proliposomes to 50 times the amount (v / v) of 5% glucose injection can quickly form a docetaxel liposome solution with an average particle size of 95%.
Embodiment 2
[0069] prescription:
[0070] Docetaxel 2g
[0071] Soy Lecithin 16.7g
[0072] Polyoxyethylene castor oil (Cremophor EL) 16.7g
[0073] PEG400 3.33g
[0074] Propylene glycol 30ml
[0075] Ethanol to 100ml
[0076] Preparation process: dissolve the prescribed amount of soybean lecithin in an appropriate amount of ethanol, then add the prescribed amount of drug, polyoxyethylene castor oil Cremophor EL, PEG400, propylene glycol and the remaining amount of ethanol, after the drug and other components are completely dissolved, The 0.22 μm microporous membrane is filtered and sterilized, and the filtrate is filled and sealed in a nitrogen-filled ampoule or a vial under aseptic conditions, that is, the docetaxel self-assembled proliposome.
[0077] Adding the prepared docetaxel self-assembled proliposomes to water for injection with 25 times the amount (v / v) can quickly form a docetaxel liposome solution with an average particle size of 90 %.
Embodiment 3
[0079] prescription:
[0080] Docetaxel 3g
[0081] Soy Lecithin 20g
[0082] Polyoxyethylene (23) lauryl ether 15.7g
[0083] Benzyl alcohol 2.2g
[0084] Isopropanol 20ml
[0085] Ethanol to 100ml
[0086] Preparation process: dissolve the prescribed amount of soybean lecithin in an appropriate amount of ethanol, then add the prescribed amount of medicine, polyoxyethylene (23) lauryl ether, benzyl alcohol, isopropanol and the remaining amount of ethanol, and wait for the medicine and other components After all the parts are dissolved, the 0.22 μm microporous membrane is filtered to sterilize, and the filtrate is filled and sealed in a nitrogen-filled ampoule or a vial under aseptic conditions, that is, the docetaxel self-assembled proliposome.
[0087] Adding the prepared docetaxel self-assembled proliposomes to 100 times the amount (v / v) of sodium chloride injection can quickly form a docetaxel liposome solution with an average particle size of 90%.
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