162 results about "Egg phospholipids" patented technology

Disclosed are infant formulas and corresponding methods of using them to promote retinal health and vision development in infants. The formulas, which are free of egg phospholipids and comprise fat, protein, carbohydrate, vitamins, and minerals, including docosahexaenoic acid and, on a ready-to-feed basis, at least about 50 mcg/liter of lutein, wherein the weight ratio of lutein (mcg) to docosahexaenoic acid (mg) is from about 1:2 to about 10:1. The formulas are also believed to be especially useful in reducing the risk of retinopathy of prematurity in preterm infants.

The invention relates to at least one nucleotide sequence, derived from a nucleotide sequence encoding an acyltransferase polypeptide comprising at least one membrane-spanning region, encoding an improved active membrane independent acyltransferase polypeptide in which at least one amino acid residue of the membrane-spanning region has been deleted and/or substituted as compared to the original acyltransferase polypeptide, wherein the encoded active membrane independent acyltransferase polypeptide can produce fatty acid esters and/or fatty acid thioesters such as triacylglycerols, diacylglycerols, monoacylglycerols, phospholipids, glycolipids, waxesters, acylated carbohydrates, acylated amino acids, and lysolipids, e.g. lysophosphospholipid, lysolecithin. Thereby one single acyltransferase can be used for the production of a huge number of products. The invention also relates to means and methods for the production of such an improved active membrane independent acyltransferase and the use of such a membrane independent acyltransferase in industry.

The invention relates to a DSPE-PEG2000-FA-modified nanometer paclitaxel liposome. A molar ratio of the DSPE-PEG2000-FA to egg yolk lecithin is 0.05% to 0.15%, and a particle size of the liposome is less than 150 nm. A preparation method of the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome comprises the following steps: first, preparing a DSPE-PEG2000-FA into a DSPE-PEG2000-FA micelle; second, performing incubation on the phosphatidyl ethanolamine-polyethylene glycol2000-folic acid micelle and a paclitaxel liposome together to obtain a DSPE-PEG2000-FA-modified nanometer paclitaxel liposome. Materials, which are forbidden to be used in clinical practice, are not used as crude materials in the present invention. According to the invention, the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome has a small particle size, and the content of the DSPE-PEG2000-FA is low; besides, the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome has good drug entrapment efficiency and good colloid stability. Moreover, the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome can be absorbed effectively by an ovarian cancer cell having properties of sensitiveness to folic acid (+) and drug resistance, and the cytotoxicity of folic acid dependence is displayed; therefore, the efficacy of the DSPE-PEG2000-FA-modified nanometer paclitaxel liposome is stronger than that of a paclitaxel injection.

The invention provides a glycyrrhetic acid and phospholipid composites of glycyrrhetate and process for preparing same by forming phospholipid compound in suitable dissolvent from glycyrrhizinic acid and its salts with a definite quantity of lecithin, thus converting the physical and chemical property, and improving the bioavailability of the glycyrrhizic acid and its salts.

The invention discloses a low-phospholipid medium-growing freshwater shrimp feed. The feed consists of the following components in percentage by mass: 15 to 16 percent of fish meal, 12 to 13 percent of fermented bean pulp, 15 to 16 percent of bean pulp, 13.95 to 25 percent of wheat flour, 10 to 11 percent of rapeseed meal, 10 to 12 percent of cottonseed meal, 3 to 4 percent of rice bran, 3 to 4 percent of squid meal, 2 to 3 percent of shrimp shell meal, 2 to 3 percent of zeolite powder, 1.4 to 2 percent of calcium dihydrogen phosphate, 0.5 to 1.0 percent of soybean phospholipid oil, 0.05 to 0.1 percent of lysolecithin and 1.0 percent of premix. The feed is used for medium-growing freshwater shrimps with body lengths of over 2.0 centimeters; and the consumption of phospholipid is reduced in the feed, and the consumption of cheap raw materials such as the rapeseed meal, the cottonseed meal, the wheat flour and the like is increased, so the cost of the feed is reduced and the benefits ofan enterprise are increased under the condition that survival and growth are not affected.

The invention relates to a composite for diagnosing a human body or an animal body, namely, an efficient Gd-loaded liposome preparation and a preparation method thereof. The liposome preparation is prepared from the following components in parts by weight: 30-80 parts of paramagnetic Gd contrast agent, 250-500 parts of lecithin, 50-200 parts of liposome stabilizer and 200-600 parts of buffer solution, based on the weight of metal Gd. The Gd-loaded liposome is prepared by using a phospholipid gel method, and the Gd-loaded amount of the liposome prepared by the method is high, thereby effectively delaying the retention period of the contrast agent in the body; and the liposome is good in storage stability.

The invention relates to the technical field of dihydromyricetin, in particular to a preparation method and an application of a multi-vesicle type dihydromyricetin liposome. The preparation method comprises the following steps of (1) collecting vine tea stems and leaves to ampelopsis grossedentata powder, and performing water bath treatment, concentrating, filtering and cooling to dihydromyricetinextracted ingredients; (2) weighing the extracted ingredients, performing dissolving to obtain a dihydromyricetin solution, and detecting purity; (3) preparing an aqueous phase solution from Tween 80and PEG-4000, preparing an oil phase solution from the dihydromyricetin, cholesterol and egg yolk lecithin, and dropwise adding the oil phase solution to the aqueous phase solution, to prepare the multi-vesicle type dihydromyricetin liposome; and (4) performing centrifugation on the taken multi-vesicle type dihydromyricetin liposome solution, taking supernatant, and detecting absorbance. For extraction of the dihydromyricetin, the egg yolk lecithin is used as a liposome formwork, and macrogol 4000 is used as a modification wall material to prepare the multi-vesicle type dihydromyricetin liposome, so that the problems that the degree of hydrolysis of the dihydromyricetin is low, the biological half-life is short, and the film penetrating force is poor, are solved.

The invention belongs to the field of biomedicine, and relates to an oral administration system capable of promoting trans-mucus penetration of a protein drug and preparation of the oral administration system, in particular to preparation of a drug carrying system capable of promoting trans-gastrointestinal tract mucus layer penetration of the protein medicine and application of the drug carryingsystem in oral administration of the protein drug. The preparation of the drug carrying system comprises the following steps: taking cetyl trimethyl ammonium bromide as a template, tetraethoxysilane as a silicon source and styrene as a pore-enlarging agent, and removing the temperature through high-temperature calcination to prepare a mesoporous silica carrier; and after the carrier adsorbs and carries the protein drug, carrying out hydrophobization modification on the surface of the drug-carrying silicon dioxide with stearic acid or cholic acid, and further using hydrophobic acting force anda zwitterionic surfactant dodecyl dimethyl betaine or dilauroyl phosphatidylcholine to form self-assembly nanoparticles. The oral administration system can promote penetration of the protein drug in the gastrointestinal tract mucus layer and improve transmembrane absorption of the drug, has the advantages of low toxicity, high drug loading capacity and the like, and has broad application prospectsin oral administration of the protein drug.

The invention relates to a procationic/ cationic liposome curcumin preparation for interventional treatment of hepatic carcinoma and a preparation method of the preparation. The preparation consists of curcumin and multiple components which can be pharmaceutically prepared into a procationic/ cationic liposome carrier. The preparation is mainly prepared from the following raw materials in percentage by weight: 0.001 to 5 percent of curcumin, and 95 to 99.999 percent of procationic/ cationic liposome carrier. The cationic liposome curcumin preparation is prepared from egg yolk lecithin, cholesterol, octadecyl amine, vitamin E, ether, anhydrous ethanol, curcumin and the like by adopting a film dispersion method. The procationic liposome curcumin preparation is prepared from egg yolk lecithin, cholesterol, [2-[[4-[(carboxymethyl) dithio]-1-imidobutyl] amino] ethyl] carbamic acid cholesteryl ester (CHETA), vitamin E, ether, anhydrous ethanol, curcumin and the like by adopting the film dispersion method. The preparation for the interventional treatment of the hepatic carcinoma is efficient and safe.

The invention discloses a konjac glucomannan-liposome composite nano food delivery system and a preparation method and an application thereof, which belong to the technical fields of a biomaterial andslow release. According to the invention, reduced alicyclic amine-grafted konjac glucomannan, cholesterol, egg yolk lecithin and food functional factors are subjected to composite assembly to the nano food delivery system through an ethanol injection method and a film hydration method. The special amphipathicity of system provides simultaneous loading of a plurality of hydrophilic and hydrophobiccomponents, realizes collaborative loading, protection, activity promoting and solubilization of a plurality of food functional factors, can obviously increase the physical and chemical stability andbioavailability, and endows the colon positioning performance and passive targeting. The product has the advantages of good biological compatibility and high entrapment rate, realizes positioning controlled release, stability augmentation and synergy for a plurality of food components, the preparation method is simple, and the method has wide application prospect in the fields of food functionalfactor delivery and synergism.

The invention discloses an antiaging nutrient composition. The antiaging nutrient composition is prepared from nucleotide, lysine, methionine, phenylalanine, threonine, tryptophan, arginine, histidine, glycine, aspartic acid, leucine, isoleucine, valine, serine, glutamine, glutamic acid, proline, tyrosine, cysteine, gamma-aminobutyric acid, taurine, orotic acid, granulesten, egg yolk lecithin, cephalin, alpha-linolenic acid, gamma-linolenic acid, inositol, hydroxytyrosol, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, niacin, folic acid, iron, zinc, manganese, copper, selenium, chromium, potassium, calcium, magnesium, choline, L-carnitine, pentose, sodium carbonate and freeze-dried powder of chick embryos hatched for three days. The antiaging nutrient composition has the advantages that neural stem cell proliferation is accelerated, amount of autophagosome is increased and activity of mesenchymal stem cells telomerase is improved.

The invention provides a fat milk injection containing phospholipid, nervonic acid and water for injection. In the injection, the content of the water for injection is larger than 70% in weight ratio; the particle size of fat globules in the injection is smaller than 1 micrometer; the phospholipid comprises lecithin, phosphatidyl ethanolamine and phosphatidyl inositol, wherein the phospholipid and the nervonic acid are combined by a weight ratio of 1:(0.005-1). The invention also provides a preparation method of the fat milk injection and application of the fat milk injection in injection and replenishment of the nervonic acid, the phospholipid, unsaturated fatty acid and medicines for preventing and treating diseases such as cranial nerve degenerative changes, cerebral injuries and disordered brain function.

The invention discloses an MOF material grafted with a phosphine ester bilayer on the surface as well as a preparation method and application thereof, and belongs to the technical field of membrane separation. The MOF material with the surface grafted with the phosphine ester bimolecular layer is characterized in that the phosphine ester bimolecular layer formed by n-octadecyl phosphonic acid-cholesterol-lecithin is grafted on the surface of a parent MOF material; and the matrix MOF material is ZIF-8, ZIF-67, ZIF-71, ZIF-90, MOF-808 or CuBTC. The preparation method comprises the steps of preparation of OPA-MOF, preparation of OLC-MOF and the like to obtain the OLC-MOF material. The mixed matrix membrane which is used for C3H6/C3H8 separation and has good C3H6 permeation rate and C3H6/C3H8 selectivity is obtained by taking the OLC-MOF material as a filler and a polymer and performing ultraviolet irradiation under the action of a photoinitiator.

The invention discloses a preparation method of copper porphyrin-folate liposome nanoparticles and application thereof as a sound-sensitive agent. The preparation method comprises the following steps:dissolving copper porphyrin with methanol, dissolving lecithin and folate liposome in chloroform, mixing the two solutions, preparing a lipid film by a rotary evaporation method, and carrying out ultrasonic hydration with ultrapure water to synthesize the copper porphyrin-folate liposome nanoparticles. The nanoparticles have excellent targeting property in tumor cells with high expression of folate receptors, and are beneficial to enrichment at tumor sites so as to improve the anti-tumor effect; and under ultrasonic excitation, the copper porphyrin absorbs sound energy to generate transitionand converts surrounding oxygen into singlet oxygen to kill tumor cells. The invention provides the sound-sensitive agent capable of generating singlet oxygen through ultrasonic excitation to kill thetumor cells, and the folate targeted liposome is used as a carrier to carry the sound-sensitive agent, so that the water solubility and the targeting property are improved, and the sonodynamic therapy (SDT) effect is further improved.

The invention belongs to the technical field of nanoparticles, and discloses a preparation method of liposome nanoparticles with low energy and thermal stability; a liposome drug naringenin or hyaluronic acid is wrapped in a lecithin-loaded surfactant solution to form nano liposome drug-wrapped nanoparticles; and the stability of the liposome nanoparticles is improved. The liposome nanoparticles provided by the invention have good effects of continuous slow release and percutaneous penetration; the residence time of acting on a skin part is prolonged; the bioavailability of a liposome medicine is improved; the form and the particle size of the liposome nanoparticles are not obviously changed after the liposome nanoparticles are kept for 30 days at 40 DEG C; the form and the particle size of the liposome nanoparticles are not obviously changed after the liposome nanoparticles are kept for 15 days at 50 DEG C; and the stability of the liposome nanoparticles is good. The invention also provides application of the liposome nanoparticles in preparation of cosmetics and medicines; and the method has important significance in development of the liposome nanoparticles with good slow release effect, thermodynamic stability and good percutaneous penetration effect.

The invention discloses a preparation method of a hydrochloric acid ciprofloxacin lipidosome preparation. The preparation method includes the steps that one part of hydrochloric acid ciprofloxacin is weighed, a phosphate buffer solution is added and stirred, and a hydrochloric acid ciprofloxacin solution is obtained; 2, blank liposome is prepared, wherein 10-50 parts of soya bean lecithin and 5-40 parts of cholesterol are weighed and mixed, chloroform is added and stirred for being dissolved, decompression is conducted for removing solvent, and a blank phospholipid membrane is prepared; 3, the membrane is dissolved through a small amount of chloroform, the hydrochloric acid ciprofloxacin solution obtained in step 1 and the phosphate buffer solution are taken for being added into an acetate solution, ultrasound treatment is conducted for 10-30 minutes through a bath type ultrasonic instrument at the temperature of 45-60 DEG C, a stable solution is formed, the obtained lipidosome solution is filtered twice through a microfiltration membrane, granulation is conducted, and the hydrochloric acid ciprofloxacin lipidosome preparation is obtained. The lipidosome produced through the ultrasonic instrument has the advantages that the particle size is small, particle size distribution is narrower, and the lipidosome has good preparation nature and target ability, can improve the curative effect, has a long-term effect, can reduce drug toxicity and can improve the drug stability.

The invention discloses a magnetic liposome and a method for preparing the same. The magnetic liposome wraps medicine inside the liposome; and magnetic particles are coated outside the liposome. The preparation method comprises the following steps that: a yolk lecithin solution and a cholesterin solution are mixed in an eggplant-shaped bottle according to the molar ratio of 2:1 to 2.5:1; the mixture is subjected to rotary evaporation to form a liposome film; then a phosphate buffering solution is used to carry out full hydration on the liposome film to obtain the liposome of which the surface is provided with negative charges; then, cationic polyelectrolyte-poly diallyl dimethyl ammonium chloride, anionic polyelectrolyte which is sodium polystyrene sulfonate and cationic polyelectrolyte which is poly diallyl dimethyl ammonium chloride are subjected to alternate adsorption; and finally, through the charge action and a self-assembling method, Fe3O4 magnetic particles of which the surfaces are provided with negative charges are deposited on the surface of the liposome to obtain the magnetic liposome. As the inside of the liposome is packed with the medicine, the magnetic particles are deposited on the surface of the liposome and a finite space of the inner space of the liposome is totally packed with the medicine, the packing amount of the medicine is improved and the magnetic content is simultaneously improved.

The invention relates to the field of pharmaceutical preparations, and in particular to a heparin-modified cationic liposome. The cationic liposome is characterized by consisting of 3 parts of heparin, 5-35 parts of egg yolk lecithin, 0.5-7 parts of cholesterol, 1-2 parts of a cationic material, 1 part of a medicine and 1 part of a freeze-drying protective additive. The invention also discloses a preparation method of the heparin-modified cationic liposome. The stability and safety of the heparin-modified cationic liposome provided by the invention can be obviously improved. The heparin-modified cationic liposome has functions of targeting tumor and tumor angiogenesis; and the heparin-modified cationic liposome can remarkably reduce toxic and side effects caused by chemotherapy drugs.

The invention discloses a sanguisorba officinalis aglycone lipidosome, which is prepared from the following raw and auxiliary materials in proportion by weight: 1 part of sanguisorba officinalis aglycone and 2 to 40 parts of carrier materials, wherein the carrier materials are prepared from hydrogenated soybean phospholipids, distearoyl phosphoethanolamine-polyethyleneglycol 2000 and cholesterin according to a weight ratio of 5:(1 to 4):(1 to 2). The invention also provides a preparation method and a purpose of the lipidosome. The lipidosome has the advantages that the number of peripheral blood leucocytes, neutrophilic granulocytes, red cells, blood platelets, hemoglobin and bone marrow hematopoietic stem cells can be obviously increased; and the obvious effects of treating and/or preventing bone marrow suppression are achieved.