Efficient Gd-loaded liposome preparation and preparation method thereof

Abstract

The invention relates to a composite for diagnosing a human body or an animal body, namely, an efficient Gd-loaded liposome preparation and a preparation method thereof. The liposome preparation is prepared from the following components in parts by weight: 30-80 parts of paramagnetic Gd contrast agent, 250-500 parts of lecithin, 50-200 parts of liposome stabilizer and 200-600 parts of buffer solution, based on the weight of metal Gd. The Gd-loaded liposome is prepared by using a phospholipid gel method, and the Gd-loaded amount of the liposome prepared by the method is high, thereby effectively delaying the retention period of the contrast agent in the body; and the liposome is good in storage stability.

Description

technical field

[0001] The invention relates to a liposome preparation of a paramagnetic gadolinium contrast agent for diagnosis, which has the characteristics of high-efficiency gadolinium loading and slow release, and can be used as a contrast enhancement agent for diagnostic imaging forms such as MRI, CT, and scintigraphy. And then used for early diagnosis of tumor. Background technique

[0002] Tumors are a serious threat to human health and life. Around the world, about 6 million people die from malignant tumors every year, and about 10 million people are diagnosed. The key problem facing tumor treatment is how to detect, diagnose and treat early. At present, there are a variety of tumor diagnostic techniques in imaging, such as magnetic resonance imaging, X-ray imaging, ultrasound imaging and nuclear medicine imaging. Among them, the contrast agent is used to enhance the intensity of the image, by changing the local magnetic field strength or relaxation time of the t...

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